The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.

Autor: Dropmann A; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Alex S; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Schorn K; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Tong C; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Caccamo T; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Godoy P; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany., Ilkavets I; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Liebe R; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University, Leipziger Straße 44, 39120, Magdeburg, Germany., Gonzalez D; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany., Hengstler JG; IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany., Piiper A; Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Quagliata L; Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland., Matter MS; Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland., Waidmann O; Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Finkelmeier F; Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Feng T; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Weiss TS; Children's University Hospital (KUNO), Center for Liver Cell Research, University Hospital Regensburg, Josef-Engert-Straße 9, 93053, Regensburg, Germany., Rahbari N; Department of Surgery and European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany; Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany., Birgin E; Department of Surgery and European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany; Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany., Rasbach E; Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany; Department of Surgery, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Roessler S; Institute of Pathology, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany., Breuhahn K; Institute of Pathology, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany., Tóth M; Institute of Pathology, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany., Ebert MP; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany; DKFZ-Hector Cancer Institute at the University Medical Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117, Heidelberg, Germany., Dooley S; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Hammad S; Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany., Meindl-Beinker NM; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Electronic address: Nadja.Meindl-Beinker@umm.de.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 05; Vol. 732, pp. 150409. Date of Electronic Publication: 2024 Jul 16.

CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer.

Autor: Wesener MC; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Weiler SME; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Bissinger M; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Klessinger TF; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Rose F; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Merker S; CFMP, Core Facility for Mass Spectrometry & Proteomics at the Center for Molecular Biology (ZMBH), Heidelberg University, 69120 Heidelberg, Germany., Luzarowski M; CFMP, Core Facility for Mass Spectrometry & Proteomics at the Center for Molecular Biology (ZMBH), Heidelberg University, 69120 Heidelberg, Germany., Ruppert T; CFMP, Core Facility for Mass Spectrometry & Proteomics at the Center for Molecular Biology (ZMBH), Heidelberg University, 69120 Heidelberg, Germany., Helm B; DKFZ, German Cancer Research Center Heidelberg, 69120 Heidelberg, Germany., Klingmüller U; DKFZ, German Cancer Research Center Heidelberg, 69120 Heidelberg, Germany., Schirmacher P; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Breuhahn K; Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 05; Vol. 25 (15). Date of Electronic Publication: 2024 Aug 05.

Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.

Autor: Scherr AL; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Nader L; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Xu K; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Elssner C; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Ridder DA; Department of General Pathology, University Hospital Mainz, Mainz, Germany., Nichetti F; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.; Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Mastel M; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Fritzsche S; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Kelmendi E; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Schmitt N; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Hoffmeister-Wittmann P; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.; Department of Radiooncology, University Hospital Heidelberg, Heidelberg, Germany., Weiler SME; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Korell F; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Albrecht T; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Schwab M; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Isele H; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Kessler A; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Hüllein J; Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Seretny A; Helmholtz-University Group 'Cell Plasticity and Epigenetic Remodeling', German Cancer Research Center (DKFZ), Heidelberg, Germany., Ye L; Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich., Urbanik T; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Welte S; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.; Department of Radiooncology, University Hospital Heidelberg, Heidelberg, Germany., Leblond AL; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland., Heilig CE; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Translational Medical Oncology, NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany., Rahbari M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Ali A; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Gallage S; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Lenoir B; Clinical Cooperation Unit 'Applied Tumor Immunity', German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Wilhelm N; Clinical Cooperation Unit 'Applied Tumor Immunity', German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Gärtner U; Interfaculty Biomedical Research Facility, University of Heidelberg, Heidelberg, Germany., Ogrodnik SJ; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Springfeld C; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Tschaharganeh D; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Helmholtz-University Group 'Cell Plasticity and Epigenetic Remodeling', German Cancer Research Center (DKFZ), Heidelberg, Germany., Fröhling S; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Translational Medical Oncology, NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany., Longerich T; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Schulze-Bergkamen H; Department of Internal Medicine II, Marien-Hospital, Wesel, Germany., Jäger D; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Brandl L; Institute of Pathology, Medical Faculty, Ludwig-Maximilians-University, Munich, Germany., Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Straub BK; Department of General Pathology, University Hospital Mainz, Mainz, Germany., Weber A; Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland., De Toni EN; Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich., Goeppert B; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.; The M3 Research Center, University Clinic Tübingen (UKT), Medical faculty, Tübingen, Germany., Jackstadt R; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Roessler S; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Breuhahn K; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany., Köhler BC; Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Aug 01; Vol. 80 (2), pp. 278-294. Date of Electronic Publication: 2023 Nov 02.

SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma.

Autor: Wan S; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., He QY; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Yang Y; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Liu F; YongDing Clinical Institute of Soochow University, Hygeia Suzhou YongDing Hospital, Suzhou, China., Zhang X; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Guo X; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Niu H; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Wang Y; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Liu YX; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Ye WL; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Li XM; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., ZhuanSun XM; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Sun P; Department of Bioinformatics, Suzhou Medical College of Soochow University, Soochow University, Suzhou, China., He XS; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Hu G; Department of Bioinformatics, Suzhou Medical College of Soochow University, Soochow University, Suzhou, China., Breuhahn K; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Zhao H; Department of General Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China., Wu GQ; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China., Wu H; Suzhou Medical College of Soochow University & Clinical Medicine Research Institute of Soochow University and Suzhou BenQ Medical Center, Soochow University, Suzhou, China.

Publikováno v: Cancer research [Cancer Res] 2024 Jun 04; Vol. 84 (11), pp. 1872-1888.

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