Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brett Zirkle"'
Autor:
Hanjing Yang, Fumiaki Ito, Aaron D. Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P. Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S. Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into do
Externí odkaz:
https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
Autor:
Wenbo Wang, Jian Ma, Jianhui Nie, Jia Li, Shouchun Cao, Lan Wang, Chuanfei Yu, Weijin Huang, Yuhua Li, Yongxin Yu, Mifang Liang, Brett Zirkle, Xiaojiang S. Chen, Xuguang Li, Wei Kong, Youchun Wang
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1584-1592 (2019)
ABSTRACTThe genetic and/or antigenic differences between street rabies virus (RABV) and vaccine strains could potentially affect effectiveness of rabies vaccines. As such, it is important to continue monitoring the glycoprotein (G) of the street isol
Externí odkaz:
https://doaj.org/article/b393cb72441c4b30a4f77a0232067125
Autor:
Linda Chelico, Brett Zirkle, Shu-Xing Li, Robin P. Love, Fumiaki Ito, Amit Gaba, Hanjing Yang, Maocai Yan, Aaron Wolfe, Xiaojiang S. Chen, Nazanin Mohammadzadeh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30b007bdef0874886c3dfafbfb9f9ee
https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
Autor:
Shouchun Cao, Yongxin Yu, Wei Kong, Brett Zirkle, Weijin Huang, Jianhui Nie, Jia Li, Youchun Wang, Xiaojiang S. Chen, Mifang Liang, Wenbo Wang, Lan Wang, Chuanfei Yu, Xuguang Li, Jian Ma, Yuhua Li
Publikováno v:
Emerging Microbes & Infections
The genetic and/or antigenic differences between street rabies virus (RABV) and vaccine strains could potentially affect effectiveness of rabies vaccines. As such, it is important to continue monitoring the glycoprotein (G) of the street isolates. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580bbb17913799d4df66de31459fa886
https://doi.org/10.1080/22221751.2019.1683436
https://doi.org/10.1080/22221751.2019.1683436
Autor:
Brett Zirkle, Hanjing Yang, Fumiaki Ito, Aaron Wolfe, Vagan Arutiunian, Xiao Xiao, Shu-Xing Li, Xiaojiang S. Chen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine deaminases that are important for innate immune defense and have been implicated in cancer biogenesis. To understand the structural basis for A3H biochemical function, we determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2219bfab4a4f662a3172b95ee886d
https://doi.org/10.1038/s41598-018-21955-0
https://doi.org/10.1038/s41598-018-21955-0
Autor:
Xiaojiang S. Chen, Jian Ma, Jianhui Nie, Wei Kong, Wenbo Wang, Weijing Huang, Kai Gao, Youchun Wang, Brett Zirkle
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 69:270-277
BACKGROUND HIV-1 gp120/gp41 is heavily modified by n-linked carbohydrates that play important roles either in correct folding or in shielding vulnerable viral protein surfaces from antibody recognition. METHODS In our previous work, 25 potential N-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd4c26f01841c9d67fd07cecbdb7c36
https://doi.org/10.1097/qai.0000000000000595
https://doi.org/10.1097/qai.0000000000000595
Autor:
Yao Fang, Hanjing Yang, Xiao Xiao, Guillaume Besse, Xiaojiang S. Chen, Vagan Arutiunian, Brett Zirkle, Cherie Morimoto
Publikováno v:
Nucleic Acids Research
The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d3d69b47f9f4d35501c039c7b6be04
https://pubmed.ncbi.nlm.nih.gov/28575276
https://pubmed.ncbi.nlm.nih.gov/28575276
Publikováno v:
Developmental Dynamics. 243:1606-1618
Background: Specific molecules involved in early inductive signaling from anterior neural tissue to the placodal ectoderm to establish a lens-forming bias, as well as their regulatory factors, remain largely unknown. In this study, we sought to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2ad84f30f110d440632ac96ef6cb17
https://doi.org/10.1002/dvdy.24193
https://doi.org/10.1002/dvdy.24193
Autor:
Krisha McKee, Gilad Ofek, John R. Mascola, Zhongyu Zhu, Yongping Yang, Nicole A. Doria-Rose, Dimiter S. Dimitrov, Baoshan Zhang, Sijy O'Dell, Ivelin S. Georgiev, Gwo-Yu Chuang, Brett Zirkle, Peter D. Kwong
Publikováno v:
Journal of Virology. 88:2426-2441
Antibodies m66.6 and 2F5 are the only effective human HIV-1-neutralizing antibodies reported thus far to recognize the N-terminal region of the membrane-proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86e6f937e0dfed38ddc7fe5e508ca14
https://doi.org/10.1128/jvi.02837-13
https://doi.org/10.1128/jvi.02837-13