Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Brett Waddell"'
Autor:
Michal Bista, David Smithson, Aleksandra Pecak, Gabriella Salinas, Katarzyna Pustelny, Jaeki Min, Artur Pirog, Kristin Finch, Michal Zdzalik, Brett Waddell, Benedykt Wladyka, Sylwia Kedracka-Krok, Michael A Dyer, Grzegorz Dubin, R Kiplin Guy
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37518 (2012)
SJ-172550 (1) was previously discovered in a biochemical high throughput screen for inhibitors of the interaction of MDMX and p53 and characterized as a reversible inhibitor (J. Biol. Chem. 2010; 285:10786). Further study of the biochemical mode of a
Externí odkaz:
https://doaj.org/article/50c3d2a731444c08bd0b42fc618a17eb
Autor:
Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.
Externí odkaz:
https://doaj.org/article/948c7729db444ae0965cb207d8ea6853
Akademický článek
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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Autor:
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang, Suren Felekyan, Katherina Hemmen, Aaron H. Phillips, Mi-Kyung Yun, M. Brett Waddell, Cheon-Gil Park, Sivaraja Vaithiyalingam, Luigi Iconaru, Stephen W. White, Peter Tompa, Claus A. M. Seidel, Richard Kriwacki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated a
Externí odkaz:
https://doaj.org/article/68150062dc9d4c4082ba200461d73f70
Autor:
Philip M. Potter, Anang A. Shelat, Stephen W. White, R. Kiplin Guy, Daniel Savic, Taosheng Chen, Martine F. Roussel, Marie Morfouace, Richard E. Lee, Jun Yang, Vincent A. Boyd, Nagakumar Bharatham, Brandon M. Young, Jeanine E. Price, Jonathan A. Low, Kevin W. Freeman, Rachelle R. Olsen, William R. Shadrick, Zhenmei Li, Geoffrey Neale, Sourav Das, M. Brett Waddell, Michele Connelly, Sergio C. Chai, Barbara Jonchere, Nancy E. Martinez, Lyudmila Tsurkan, Mi-Kyung Yun, Liying Chi, P. Jake Slavish
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5d71e4e32bd0d5208d4d9130ecd2d2
https://doi.org/10.1158/0008-5472.c.6511882.v1
https://doi.org/10.1158/0008-5472.c.6511882.v1
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
Autor:
Barbara Jonchere, Jonathan Low, Michele Connelly, Liying Chi, Sergio C. Chai, R. Kiplin Guy, Kevin W. Freeman, Brandon Young, Jeanine E. Price, Mi-Kyung Yun, Marie Morfouace, Anang A. Shelat, Geoffrey Neale, Rachelle R. Olsen, Nagakumar Bharatham, Daniel Savic, Stephen W. White, P. Jake Slavish, Vincent A. Boyd, Lyudmila Tsurkan, Jun J. Yang, Nancy E. Martinez, Zhenmei Li, Martine F. Roussel, Philip M. Potter, M. Brett Waddell, William R. Shadrick, Richard E. Lee, Taosheng Chen, Sourav Das
Publikováno v:
Cancer Res
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d687ae06b408a0a8a364651477a03f
https://doi.org/10.1158/0008-5472.can-19-3934
https://doi.org/10.1158/0008-5472.can-19-3934
Autor:
Prashasti Kumar, Pratul K. Agarwal, M. Brett Waddell, Tanja Mittag, Engin H. Serpersu, Matthew J. Cuneo
Publikováno v:
Angewandte Chemie. 131:16406-16412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbeac05486bf96cebd4a03134337defc
https://doi.org/10.1002/ange.201908535
https://doi.org/10.1002/ange.201908535
Autor:
Philip M. Potter, Sergio C. Chai, Brett Waddell, Marie Morfouace, Anang A. Shelat, Nagakumar Bharatham, R. Kiplin Guy, William R. Shadrick, Brandon Young, Peter J. Slavish, Richard E. Lee, Jonathan Low, Stefan Knapp, Cynthia Tallant, Vincent A. Boyd, Michele Connelly, Taosheng Chen, Martine F. Roussel
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:25-36
Within the last decade, the Bromodomain and Extra-Terminal domain family (BET) of proteins have emerged as promising drug targets in diverse clinical indications including oncology, auto-immune disease, heart failure, and male contraception. The BET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a923a808384ce4da801ffe85c99a1360
https://doi.org/10.1016/j.bmc.2017.10.042
https://doi.org/10.1016/j.bmc.2017.10.042
Autor:
Tanja Mittag, Pratul K. Agarwal, Engin H. Serpersu, M. Brett Waddell, Matthew J. Cuneo, Prashasti Kumar
Publikováno v:
Angewandte Chemie (International ed. in English). 58(45)
The position, bonding and dynamics of hydrogen atoms in the catalytic centers of proteins are essential for catalysis. The role of short hydrogen bonds in catalysis has remained highly debated and led to establishment of several distinctive geometric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc82b97736c769085cfafb3ceb23f41b
https://pubmed.ncbi.nlm.nih.gov/31515870
https://pubmed.ncbi.nlm.nih.gov/31515870
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Autor:
Mi-Kyung Yun, Maksym Tsytlonok, Peter Tompa, Sivaraja Vaithiyalingam, Suren Felekyan, Claus A. M. Seidel, Aaron H. Phillips, Luigi I. Iconaru, Yuefeng Wang, Hugo Sanabria, Stephen W. White, M. Brett Waddell, Richard W. Kriwacki, Katherina Hemmen, Cheon-Gil Park
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell divi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebf5b582a25ff50bd576925e3ed1b6a
http://arxiv.org/abs/1812.07009
http://arxiv.org/abs/1812.07009