Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brett W. C. Kennedy"'
Autor:
Campbell F. Maceachern, Brett W. C. Kennedy, P. James Ross, Lionel Broche, David J. Lurie, George P. Ashcroft
Publikováno v:
Physica Medica
Highlights • Fast Field-Cycling can assess proteoglycan content in vitro. • The T1 vs field strength profile of cartilage varies in osteoarthritis. • These biomarkers can potentially be accessed in vivo using Field-Cycling Imaging. • Potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c091d2902c4a9433d0ab7f5cd21a747f
https://doi.org/10.1016/j.ejmp.2021.05.034
https://doi.org/10.1016/j.ejmp.2021.05.034
Autor:
Anurag Choksey, Benjamin D. Thackray, Vicky Ball, Lea Hong Tuan Ha, Eshita Sharma, Brett W. C. Kennedy, Ryan D. Carter, John Broxholme, Michael P Murphy, Lisa C Heather, Damian J Tyler, Kerstin N Timm
Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects, leading to functional cardiac decline and ultimately, congestive heart failure (HF). Impaired mitochondrial function and energetics are thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebec8ad71777a2476e5e357c0b53f591
https://doi.org/10.1101/2022.08.17.504253
https://doi.org/10.1101/2022.08.17.504253
Changes in tumor metabolism may accompany disease progression and can occur following treatment, often before there are changes in tumor size. We focus here on imaging methods that can be used to image various aspects of tumor metabolism, with an emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd2a1bb23ab3d7677732067a2c7acc
https://www.repository.cam.ac.uk/handle/1810/260790
https://www.repository.cam.ac.uk/handle/1810/260790
Autor:
Simon R. Bayly, Rory L. Arrowsmith, Franklin I. Aigbirhio, Julia Zhong, Sofia I. Pascu, Brett W C Kennedy, David Collison, Grant C. Churchill, Martin Christlieb, Philip A. Waghorn, Parvinder K. Aley, Jonathan R. Dilworth, Radoslaw M. Kowalczyk, Rex M. Tyrrell
Copper bis(4-ethyl-3-thiosemicarbazonato) acenaphthenequinone (1) and copper bis(4-methyl-3-thiosemicarbazonato) acenaphthenequinone (2) are synthesized and characterized in solution, in the solid state, and radiolabeled. Serum-protein binding radioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769760ffe4b0990be48d78e0779edadf
https://ora.ox.ac.uk/objects/uuid:60beba3c-9217-4339-9f6e-7c89b2cd1fb9
https://ora.ox.ac.uk/objects/uuid:60beba3c-9217-4339-9f6e-7c89b2cd1fb9
Autor:
Eva M, Serrao, Tiago B, Rodrigues, Ferdia A, Gallagher, Mikko I, Kettunen, Brett W C, Kennedy, Sarah L, Vowler, Keith A, Burling, Kevin M, Brindle
Publikováno v:
Nmr in Biomedicine
Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::481c3f76763e678a2157993f95b6ba11
https://pubmed.ncbi.nlm.nih.gov/27309986
https://pubmed.ncbi.nlm.nih.gov/27309986
Autor:
Brett W. C. Kennedy, Kevin M. Brindle, Sarah E. Bohndiek, Ferdia A. Gallagher, De-En Hu, Mikko I. Kettunen, Timothy H. Witney
Publikováno v:
Molecular Cancer Therapeutics. 9:3278-3288
Nuclear spin hyperpolarization can dramatically increase the sensitivity of the 13C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized 13C-labeled substrates in vivo. Here, we report a preclinical study o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7033e5ba6678be7cf97dca9bc37889b1
https://doi.org/10.1158/1535-7163.mct-10-0706
https://doi.org/10.1158/1535-7163.mct-10-0706
Autor:
Brett W. C. Kennedy, Phyo K. Myint, I.A. Rankin, Campbell F. Maceachern, George P. Ashcroft, R. James, H. Rehman, Lionel Broche, David J. Lurie
Publikováno v:
Osteoarthritis and Cartilage. 26:S467
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994a60610f6b289c36b8d0d5437309fd
https://doi.org/10.1016/j.joca.2018.02.881
https://doi.org/10.1016/j.joca.2018.02.881
Autor:
Brett W. C. Kennedy, Kevin M. Brindle, De-En Hu, Tiago B. Rodrigues, Eva M. Serrao, Mikko I. Kettunen
Publikováno v:
Nature medicine
In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bca25ddc79d7e0ab6bbfe71c6b12a8
http://europepmc.org/articles/PMC3886895
http://europepmc.org/articles/PMC3886895
Autor:
Timothy H. Witney, Kenneth G. C. Smith, Mikko I. Kettunen, De-En Hu, Menna R. Clatworthy, Brett W. C. Kennedy, Kevin M. Brindle, Lorna B. Jarvis, Sarah E. Bohndiek, Ferdia A. Gallagher, Rebeccah J. Mathews
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(33)
Acute kidney injury (AKI) is a common and important medical problem, affecting 10% of hospitalized patients, and it is associated with significant morbidity and mortality. The most frequent cause of AKI is acute tubular necrosis (ATN). Current imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e339fdeb43a7c5ca3e86b2f92950fc7
https://pubmed.ncbi.nlm.nih.gov/22837393
https://pubmed.ncbi.nlm.nih.gov/22837393
Publikováno v:
Magnetic resonance in medicine. 70(5)
Purpose To assess the blood-tissue distribution of hyperpolarized 13C-labeled molecules in vivo. Methods Spin-echo experiments with simultaneous acquisition of the free induction decay (FID) signal following the excitation pulse and the spin-echo sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40743cfc1644d7d5f0526881e29f1277
https://pubmed.ncbi.nlm.nih.gov/23280500
https://pubmed.ncbi.nlm.nih.gov/23280500