Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Brett T. Spear"'
Autor:
Jieyun Jiang, Courtney Turpin, Guofang (Shirley) Qiu, Mei Xu, Eun Lee, Terry D. Hinds Jr., Martha L. Peterson, Brett T. Spear
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3550-3562 (2022)
Abstract Liver cancer, comprised primarily of hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths worldwide and increasing in Western countries. We previously identified the transcription factor zinc fingers and homeoboxes 2 (
Externí odkaz:
https://doaj.org/article/849e65001ae14f83b9b1dcb7478ed4ad
Publikováno v:
BioTechniques, Vol 47, Iss 5, Pp 919-924 (2009)
We describe a novel device that can be used for the transcervical transfer of embryos into pseudopregnant female mice. This nonsurgical embryo transfer (NSET) device is as efficient as standard surgical embryo transfer in the production of transgenic
Externí odkaz:
https://doaj.org/article/666da2ce8f9043c8916d1f29b88aedcf
Zinc fingers and homeoboxes 2 (ZHX2) functions as a tumor suppressor in several models of hepatocellular carcinoma (HCC), presumably through its control of target genes. Previous microarray data suggested that Elongation of Very Long Chain Fatty Acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4022906f3f11b91046c7e8dced676419
https://doi.org/10.1101/2022.09.02.506374
https://doi.org/10.1101/2022.09.02.506374
Autor:
Frederique Yiannikouris, Gertrude Arthur, Ryan E. Temel, Brett T. Spear, Gregory A. Graf, Nathan R. Shelman, Eva Gatineau, Kellea Nichols, Audrey Poupeau
Publikováno v:
Am J Physiol Endocrinol Metab
Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver steatosis. Therefore, we aimed to determine the relative contribution of PRR and its soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ff67d422fe8f2443a6964f1cc29a12
https://doi.org/10.1152/ajpendo.00135.2020
https://doi.org/10.1152/ajpendo.00135.2020
Publikováno v:
Genome Biology and Evolution
The Zinc Fingers and Homeoboxes (Zhx) proteins, Zhx1, Zhx2, and Zhx3, comprise a small family of proteins containing two amino-terminal C2–H2 zinc fingers and four or five carboxy-terminal homeodomains. These multiple homeodomains make Zhx proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7cda272e466a32a6d4c378098d44b0
http://europepmc.org/articles/PMC7144352
http://europepmc.org/articles/PMC7144352
Publikováno v:
Mamm Genome
BALB/cJ mice exhibit considerable phenotypic differences with other BALB/c substrains. Some of these traits involve the liver, including persistent postnatal expression of genes that are normally expressed only in the fetal liver and reduced expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6964b49014e4733f2c5d8ad374a53aab
https://doi.org/10.1007/s00335-019-09811-6
https://doi.org/10.1007/s00335-019-09811-6
Autor:
Roberto Gedaly, Roberto Galuppo, Michael F Daily, Malay Shah, Erin Maynard, Changguo Chen, Xiping Zhang, Karyn A Esser, Donald A Cohen, B Mark Evers, Jieyun Jiang, Brett T Spear
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99272 (2014)
Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular carcinomas (HCC), and a significant number of these have mutations in the β-catenin gene. Therefore, effective inhibition of this pathway could provide a no
Externí odkaz:
https://doaj.org/article/7b8af5a944184c5bbfce59a7f1a2d4e4
Publikováno v:
Gene
The mammalian Cytochrome P450 (Cyp) gene superfamily encodes enzymes involved in numerous metabolic pathways and are frequently expressed in the liver. Despite the remarkably high sequence similarity of Cyp2a4 and Cyp2a5 genes and their surrounding g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353338fff1e0dd3baddfd03fb3626a96
https://pubmed.ncbi.nlm.nih.gov/32987105
https://pubmed.ncbi.nlm.nih.gov/32987105
Autor:
Ryan E. Temel, Frederique Yiannikouris, Eva Gatineau, Gregory A. Graf, Audrey Poupeau, Gertrude Arthur, Kellea Nichols, Brett T. Spear
Obesity is associated with alterations in hepatic lipid metabolism. We previously identified the prorenin receptor (PRR) as a potential contributor to liver steatosis. Therefore, we aimed to determine the relative contribution of PRR and its soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a6fb10e757a9698b8fd2d8813debed
Autor:
Yaoqin Gong, Zehua Wang, Chunhong Ma, Chengjiang Gao, Yong Xu, Zhuanchang Wu, Leiqi Xu, Xiaohong Liang, Lifen Gao, Tixiao Wang, Xiaojia Song, Siyu Tan, Brett T. Spear
Publikováno v:
International Journal of Cancer. 143:3120-3130
Initiation of hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection is a complex process that includes both oncogene activation and tumor suppressor inhibition. The HBV X (HBx) protein has an important and complex role in proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70267d6861adff4731142efca9c610e
https://doi.org/10.1002/ijc.31595
https://doi.org/10.1002/ijc.31595