Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Brett T. Lund"'
Autor:
Kiel M. Telesford, Lilyana Amezcua, Lauren Tardo, Lindsay Horton, Brett T. Lund, Anthony T. Reder, Timothy Vartanian, Nancy L. Monson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
People identified with Black/African American or Hispanic/Latinx ethnicity are more likely to exhibit a more severe multiple sclerosis disease course relative to those who identify as White. While social determinants of health account for some of thi
Externí odkaz:
https://doaj.org/article/94b304e5599b4c28adc6436e6a611ec2
Autor:
Wendy Gilmore, Brett T. Lund, Peili Li, Alex M. Levy, Eve E. Kelland, Omid Akbari, Susan Groshen, Steven Yong Cen, Daniel Pelletier, Leslie P. Weiner, Adil Javed, Jeffrey E. Dunn, Anthony L. Traboulsee
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-21 (2020)
Abstract Objective To characterize long-term repopulation of peripheral immune cells following alemtuzumab-induced lymphopenia in relapsing-remitting MS (RRMS), with a focus on regulatory cell types, and to explore associations with clinical outcome
Externí odkaz:
https://doaj.org/article/c28fbcdbfa904b3d9f37eeae73f6397e
Autor:
Nicole Kashani, Eve E. Kelland, Borna Vajdi, Lauren M. Anderson, Wendy Gilmore, Brett T. Lund
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Alemtuzumab is a highly effective treatment for relapsing-remitting multiple sclerosis. It selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. We previously s
Externí odkaz:
https://doaj.org/article/a32c0f44f3e54f28a23b32a143d06001
Autor:
Sun young Kim, Eve E. Kelland, Ji hong Kim, Brett T. Lund, Xiao Chang, Kai Wang, Leslie P. Weiner
Publikováno v:
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 166-172 (2017)
Retinoic acid (RA), a metabolite of vitamin A, has been found to influence regeneration in the adult central nervous system (CNS). There may be an effect of RA in the recovery/repair in multiple sclerosis (MS), an autoimmune and neurodegenerative dis
Externí odkaz:
https://doaj.org/article/81d7c1f49a3e4637b10190253cbc2cc4
Autor:
Qiuying Zhao, Weiye Dai, Hui Yu Chen, Russell E. Jacobs, Berislav V. Zlokovic, Brett T. Lund, Axel Montagne, Alexandre Bonnin
Publikováno v:
Zhao, Q, Dai, W, Chen, H Y, Jacobs, R E, Zlokovic, B V, Lund, B T, Montagne, A & Bonnin, A 2022, ' Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation ', Proceedings of the National Academy of Sciences, vol. 119, no. 15 . https://doi.org/10.1073/pnas.2113310119
Gestational maternal immune activation (MIA) in mice induces persistent brain microglial activation and a range of neuropathologies in the adult offspring. Although long-term phenotypes are well documented, how MIA in utero leads to persistent brain
Autor:
Ashley H. Beecham, Lilyana Amezcua, Angel Chinea, Clara P. Manrique, Lissette Gomez, Andrea Martinez, Gary W. Beecham, Nikolaos A. Patsopoulos, Tanuja Chitnis, Howard L. Weiner, Philip L. De Jager, Esteban G. Burchard, Brett T. Lund, Kathryn C. Fitzgerald, Peter A. Calabresi, Silvia R. Delgado, Jorge R. Oksenberg, Jacob L. McCauley
Publikováno v:
PloS one, vol 17, iss 12
The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high a
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Alemtuzumab is a highly effective treatment for relapsing-remitting multiple sclerosis. It selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. We previously s
Autor:
Eve E. Kelland, Roslynn Stone, Erika Amundson, S. Lee, Kathleen E. Rodgers, Nicole Kashani, Brett T. Lund, Alexander M Levy
Publikováno v:
Neurobiology of Disease, Vol 127, Iss, Pp 87-100 (2019)
Multiple Sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by autoimmune and neurodegenerative pathologies for which there is no cure and no defined etiology. Although several, modestly effective, disease modifying
Autor:
Ji-Hong Kim, Kai Wang, Leslie P. Weiner, Brett T. Lund, Eve E. Kelland, Sun Young Kim, Xiao Chang
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 166-172 (2017)
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 166-172 (2017)
Retinoic acid (RA), a metabolite of vitamin A, has been found to influence regeneration in the adult central nervous system (CNS). There may be an effect of RA in the recovery/repair in multiple sclerosis (MS), an autoimmune and neurodegenerative dis
Autor:
Katherine A. Fitzgerald, Nikolaos A. Patsopoulos, Jacob L. McCauley, Clara P. Manrique, Peter A. Calabresi, Ashley Beecham, P. L. De Jager, David V. Conti, Brett T. Lund, Adam Santaniello, Noriko Isobe, Angel Chinea, C. Rubi, Sylvia Delgado, Manuel Comabella, Esteban G. Burchard, Jorge R. Oksenberg, Lilyana Amezcua, Gary W. Beecham
Publikováno v:
Mult Scler
Multiple sclerosis (Houndmills, Basingstoke, England), vol 26, iss 11
Multiple sclerosis (Houndmills, Basingstoke, England), vol 26, iss 11
Background: Substantial progress has been made toward unraveling the genetic architecture of multiple sclerosis (MS) within populations of European ancestry, but few genetic studies have focused on Hispanic and African American populations within the