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of 33
pro vyhledávání: '"Brett S, Harris"'
Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways
Autor:
Laura M. Kuznekoff, Jonathan A. Epstein, Brett S. Harris, Vickas V. Patel, Lauren J. Manderfield, Gregory E. Morley, Min Min Lu, Rajan Jain, Stacey Rentschler
Publikováno v:
Journal of Clinical Investigation. 121:525-533
Ventricular preexcitation, which characterizes Wolff-Parkinson-White syndrome, is caused by the presence of accessory pathways that can rapidly conduct electrical impulses from atria to ventricles, without the intrinsic delay characteristic of the at
Autor:
Brett S. Harris, A. Richards, Russell A. Norris, Robert A. Levine, Jean Mérot, L.K. Williams, Ricardo A. Moreno-Rodriguez, Roger R. Markwald, Adrian H. Chester, Jean-Jacques Schott, Magdi H. Yacoub, Albert Hagège, Andy Wessels, Susan A. Slaugenhaupt, Patrick Bruneval, A. Lardeux, Elena Aikawa
Publikováno v:
Developmental Dynamics. 239:2118-2127
Myxoid degeneration of the cardiac valves is a common feature in a heterogeneous group of disorders that includes Marfan syndrome and isolated valvular diseases. Mitral valve prolapse is the most common outcome of these and remains one of the most co
Autor:
Brett S. Harris, Robert G. Gourdie, Jane Jourdan, David Sedmera, Ning Zhang, Elizabeth Grant, Dana Kurkova
Publikováno v:
Developmental Dynamics. 237:1746-1753
The spatiotemporal distribution of the endothelin-converting enzyme (ECE) protein in the embryonic chick heart and the association of this polypeptide with the developing cardiac conduction system is described here for the first time. Further, we sho
Autor:
Elizabeth Thames, Measho Abreha, Brett S. Harris, Robert L. Price, Lydia E. Matesic, Neal G. Copeland, Deborah A. Swing, Heather L. Mentrup, Nancy A. Jenkins, Jessica B. Lea, Wassim A. Basheer
Gap junctions (GJ) are intercellular channels composed of connexin subunits that play a critical role in a diverse number of cellular processes in all tissue types. In the heart, GJs mediate electrical coupling between cardiomyocytes and display misl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5228011bfa885aea918ee61e1dda80bc
https://europepmc.org/articles/PMC4641030/
https://europepmc.org/articles/PMC4641030/
Autor:
Kevin T. Dyer, U. Joseph Schoepf, Carlo N. De Cecco, Richard R. Bayer, Aleksander W. Krazinski, Brett S. Harris, Daniel H. Steinberg, Felix G. Meinel, Monique K. Sandhu, Michael R. Zile
Publikováno v:
Radiology. 275(1)
To assess the accuracy of computed tomographic (CT) examinations performed for the purpose of transcatheter aortic valve replacement (TAVR) planning to diagnose obstructive coronary artery disease (CAD).With institutional review board approval, waive
Autor:
Terrence X. O'Brien, Brett S. Harris, D. Woodrow Benson, Robert G. Gourdie, Mary S. Rackley, Laura Spruill, Angela M. Edmonson
Publikováno v:
Developmental Dynamics. 235:38-49
Nkx2-5 gene mutations cause cardiac abnormalities, including deficits of function in the atrioventricular conduction system (AVCS). In the chick, Nkx2-5 is elevated in Purkinje fiber AVCS cells relative to working cardiomyocytes. Here, we show that N
Autor:
Brett S. Harris, Georg Zoidl, Carla Taveggia, Hans Werner Müller, Kristjan R. Jessen, Lawrence Wrabetz, Christiane Zoidl, Eric Parmantier, Frank Bosse, Charlotte H. Dean, Mary Rahman, Maria B Duran Alonso, Rhona Mirsky
Publikováno v:
Journal of Biological Chemistry. 279:25653-25664
To isolate new zinc finger genes expressed at early stages of peripheral nerve development, we have used PCR to amplify conserved zinc finger sequences. RNA from rat embryonic day 12 and 13 sciatic nerves, a stage when nerves contain Schwann cell pre
Autor:
Brett S. Harris, Colin T. Maguire, Robert G. Gourdie, Patrick Y. Jay, Thomas M. Schultheiss, Makoto Tanaka, Antje Buerger, Dan M. Roden, Sabina Kupershmidt, Charles I. Berul, Terrence X. O'Brien, Hiroko Wakimoto, Seigo Izumo
Publikováno v:
Journal of Clinical Investigation. 113:1130-1137
Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 ge
Autor:
Seigo Izumo, Robert G. Gourdie, Laura A. Barbosky, Charles I. Berul, Patrick Y. Jay, Brett S. Harris, Antje Buerger, Terrence X. O'Brien, Olga Rozhitskaya, Ellen McCusty, Colin T. Maguire
Publikováno v:
The Anatomical Record. :966-972
Mutations of Nkx2-5 cause congenital heart disease and atrioventricular block in man. The altered expression of an electrophysiologic protein regulated by Nkx2-5 was originally presumed to cause the conduction defect, but when no such protein was fou
Autor:
Patrick Y. Jay, Seigo Izumo, Terrence X. O'Brien, Robert G. Gourdie, Brett S. Harris, Mary S. Rackley
Publikováno v:
The Anatomical Record. :1036-1045
The development of the complex network of specialized cells that form the atrioventricular conduction system (AVCS) during cardiac morphogenesis occurs by progressive recruitment within a multipotent cardiomyogenic lineage. Understanding the molecula