Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Brett R. Blackman"'
Autor:
Maria S. Collado, Banumathi K. Cole, Robert A. Figler, Mark Lawson, David Manka, Michael B. Simmers, Steve Hoang, Felipe Serrano, Brett R. Blackman, Sanjay Sinha, Brian R. Wamhoff
Publikováno v:
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1673-1683 (2017)
Abstract Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood vessel, they represent an immature phenot
Externí odkaz:
https://doaj.org/article/13ade552b30543e5bd3d6e5691a0dbeb
Autor:
Robert W Tilghman, Edik M Blais, Catharine R Cowan, Nicholas E Sherman, Pablo R Grigera, Erin D Jeffery, Jay W Fox, Brett R Blackman, Daniel J Tschumperlin, Jason A Papin, J Thomas Parsons
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37231 (2012)
Tumor cells in vivo encounter diverse types of microenvironments both at the site of the primary tumor and at sites of distant metastases. Understanding how the various mechanical properties of these microenvironments affect the biology of tumor cell
Externí odkaz:
https://doaj.org/article/673a17e071dc46ae9e1ff2e9ef483c46
Autor:
Robert W Tilghman, Catharine R Cowan, Justin D Mih, Yulia Koryakina, Daniel Gioeli, Jill K Slack-Davis, Brett R Blackman, Daniel J Tschumperlin, J Thomas Parsons
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12905 (2010)
The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the microen
Externí odkaz:
https://doaj.org/article/4a8c02aa9e524f6f874edcd48cd9d95d
Autor:
Brian R. Wamhoff, Maria Sol Collado, David Manka, Steve Hoang, Banumathi K. Cole, Brett R. Blackman, Robert A. Figler, Michael B. Simmers, Mark J. Lawson, Felipe Serrano, Sanjay Sinha
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1673-1683 (2017)
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1673-1683 (2017)
Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood vessel, they represent an immature phenotype. Hemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b7024098f8cc2add5e066506489e87
https://doi.org/10.1002/sctm.17-0004
https://doi.org/10.1002/sctm.17-0004
Autor:
Joshua L, Heuslein, Joshua K, Meisner, Xuanyue, Li, Ji, Song, Helena, Vincentelli, Ryan J, Leiphart, Elizabeth G, Ames, Brett R, Blackman, Richard J, Price
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:2354-2365
Objective— Collateral arteriogenesis, the growth of existing arterial vessels to a larger diameter, is a fundamental adaptive response that is often critical for the perfusion and survival of tissues downstream of chronic arterial occlusion(s). She
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50ededfed99e7b01f07f2fefa06faea
https://doi.org/10.1161/atvbaha.115.305775
https://doi.org/10.1161/atvbaha.115.305775
Autor:
Brian R. Wamhoff, Arun J. Sanyal, Banumathi K. Cole, Ajit Dash, Stephen A. Hoang, Brett R. Blackman, Ryan E. Feaver, Svetlana Marukian, Mark J. Lawson, Robert A. Figler
Publikováno v:
JCI Insight. 1
A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver model was engineered to incorporate hepatic sinusoidal flow, transport, and lipotoxic stress r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f79ab9cf50aded0d484894f7230336
https://doi.org/10.1172/jci.insight.90954
https://doi.org/10.1172/jci.insight.90954
Autor:
David Manka, Brian R. Wamhoff, Arun J. Sanyal, Banumathi K. Cole, Robert A. Figler, Ryan E. Feaver, S. Marukian, Aaron J. Mackey, Brett R. Blackman, Ajit Dash, Mark J. Lawson, Maria Sol Collado, Stephen A. Hoang
Nonalcoholic steatohepatitis (NASH) is an emerging health crisis with no approved therapies. Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, shows promise in NASH trials. However, the precise mechanisms mediating OCA effects and impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662532fcafde1a77101476e7b6cad014
https://europepmc.org/articles/PMC5191970/
https://europepmc.org/articles/PMC5191970/
Autor:
Brian R. Wamhoff, Ryan E. Feaver, Nicole E. Hastings, Edward L. LeCluyse, Ajit Dash, Timothy L. Pruett, Diana J Berry, Michael B. Simmers, Tye G. Deering, Brett R. Blackman
Publikováno v:
American Journal of Physiology-Cell Physiology. 304:C1053-C1063
In vitro primary hepatocyte systems typically elicit drug induction and toxicity responses at concentrations much higher than corresponding in vivo or clinical plasma Cmax levels, contributing to poor in vitro-in vivo correlations. This may be partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d12c6b6ede5ed945e1171ce6309d67
https://doi.org/10.1152/ajpcell.00331.2012
https://doi.org/10.1152/ajpcell.00331.2012
Autor:
Yiming Xu, Brett R. Blackman, Brian R. Wamhoff, Nigel Mackman, Zhu Chen, Banumathi K. Cole, Ling Jie Kong, Michael B. Simmers, Martin L. Ogletree
Publikováno v:
Thrombosis research. 143
An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a7cfdac2973198b0592b4d72f9e667
https://pubmed.ncbi.nlm.nih.gov/27179130
https://pubmed.ncbi.nlm.nih.gov/27179130
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 8:999-1014
The frequent failure of high-throughput screening cell-based tools to accurately predict in vivo responses, coupled with limitations of animal models in predicting human safety or drug efficacy, impairs the de-risking process for biotechnology/pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f8b9afe0758c90db0bb0e21c9e220b
https://doi.org/10.1517/17425255.2012.693161
https://doi.org/10.1517/17425255.2012.693161