Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brett Monia"'
Publikováno v:
Artery Research, Vol 12 (2015)
Background: Interactions of platelets, leukocytes and the vessel wall play pivotal roles in activating coagulation and precipitating thrombosis. High levels of angiotensin II (ATII) cause arterial hypertension by a complex inflammatory pathway requir
Externí odkaz:
https://doaj.org/article/0d26689dcf3f468baabb601d256d4036
Autor:
John K. Diep, Rosie Z. Yu, Nicholas J. Viney, Eugene Schneider, Shuling Guo, Scott Henry, Brett Monia, Richard Geary, Yanfeng Wang
Publikováno v:
British Journal of Clinical Pharmacology. 88:5389-5398
Transthyretin-mediated amyloidosis is a progressive and fatal disease caused by the build-up of misfolded transthyretin (TTR) protein. Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotide targeting TTR m
Autor:
Joseph S. Palumbo, Brett Monia, Alexey Revenko, David P. Witte, Maureen Shaw, Eric S. Mullins, Eleana Harmel-Laws, Kris A. Steinbrecher, Matthew J. Flick, Keith Kombrinck, Leah Rosenfeldt, Whitney Miller, Brian Turpin
PDF file - 1869KB, Modest ASO-mediated decrease in circulating prothrombin does not significantly affect mucosal injury, inflammatory cell accumulation or local inflammatory cytokine production following DSS challenge (S1). Resolution of inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d04c9fd2aa970a0580c6314a07c8d57
https://doi.org/10.1158/0008-5472.22399734
https://doi.org/10.1158/0008-5472.22399734
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
α-1 Antitrypsin (AAT) deficiency is the leading genetic cause of emphysema; however, until recently, no genuine animal models of AAT deficiency existed, hampering the development of new therapies. This shortcoming is now addressed by both AAT-null a
Autor:
Rachel Cantrell, Leah Rosenfeldt, Bal Krishan Sharma, Benjamin Gourley, Alexey Revenko, Brett Monia, Joseph Palumbo
Publikováno v:
The Journal of Immunology. 208:121.12-121.12
CD8+ tumor infiltrating lymphocytes (TIL) are critical for tumor clearance following immune checkpoint inhibitor (ICI) therapy. Thrombin, the central hemostatic protease, is activated in the tumor microenvironment and CD8+ T cells express the thrombi
Autor:
Harikrishnan Parameshwaran, Anthony S. Weiss, Andrea Heinz, Shuling Guo, Brian M. Varisco, Qiang Fan, Christian E.H. Schmelzer, Matthew Batie, Rashika Joshi, Brett Monia
Publikováno v:
American journal of respiratory cell and molecular biology. 59(2)
Alpha-1 antitrypsin (AAT) deficiency–related emphysema is the fourth leading indication for lung transplant. Chymotrypsin-like elastase 1 (Cela1) is a digestive protease that is expressed during lung development in association with regions of elast
Autor:
Andrea Heinz, Brian M. Varisco, Christian E.H. Schmelzer, Qiang Fan, Brett Monia, Anthony S. Weiss, Harikrishnan Parameswaran, Rashika Joshi, Matthew Batie, Shuling Guo
α1-antitrypsin related lung disease (AAT-RLD) is the fourth leading indication for lung transplantation and is characterized by protease-mediated progressive emphysema that manifests in the 4th or 5th decade of life. Chymotrypsin-like elastase 1 (Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8b7c34f94b73c675c4f3ca58b29d15
Autor:
Brett Monia, Rob McKay, Humberto Jijon, Michele M. Tavernini, Ian Popoff, Michael Ma, Karen Madsen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1145-1154
poly(ADP-ribose) polymerase-2 (PARP-2) is a newly described member of the PARP family of nuclear enzymes. Previous studies have shown pharmacological inhibition of PARP activity to have a beneficial role in attenuating inflammation. We developed a ch
Autor:
Lihua Wang, Zsuzsanna S. Nagy, Hallgeir Rui, Janos Aradi, Yuling Wang, Robert A. Kirken, Rebecca A. Erwin-Cohen, Stanislaw M. Stepkowski, Brett Monia
Publikováno v:
Journal of Leukocyte Biology. 72:819-828
Signal transducer and activator of transcription (Stat)5a and Stat5b are critical for normal immune function. Progression of T cells through G1-S phase of cell cycle requires T cell receptor (TCR)- and/or cytokine-inducible tyrosine phosphorylation o
Autor:
Peter, Mullen, Fiona, McPhillips, Kenneth, MacLeod, Brett, Monia, John F, Smyth, Simon P, Langdon
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(6)
We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.First-(ISIS 5132) and second-generation (ISIS 13650) anti-Raf 1 ASOs were compared