Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brett Matzuka"'
Autor:
Jan Huisman, Jiajie Yu, William Hanley, Brett Matzuka, Katie Tuckwell, Angelica Quartino, Phyllis Chan, Leslie W. Chinn, Marita Prohn
Publikováno v:
Pharmaceutical Research
Purpose Fenebrutinib (GDC-0853), a Bruton’s tyrosine kinase (BTK) inhibitor was investigated in a Phase 2 clinical trial in patients with rheumatoid arthritis (RA). Our aim was to apply a model-informed drug development (MIDD) approach to examine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be379e185e0ae172ba54894edd5cdf3
https://doi.org/10.1007/s11095-020-2761-x
https://doi.org/10.1007/s11095-020-2761-x
Autor:
Katie Tuckwell, Angelica Quartino, Marita Prohn, Leslie W. Chinn, Jiajie Yu, Brett Matzuka, William Hanley, Jan Huisman, Phyllis Chan
Publikováno v:
Pharmaceutical research. 37(2)
Purpose Fenebrutinib (GDC-0853), a Bruton’s tyrosine kinase (BTK) inhibitor was investigated in a Phase 2 clinical trial in patients with rheumatoid arthritis (RA). Our aim was to apply a model-informed drug development (MIDD) approach to examine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1e1dfe34f3b83c94847c31aa7bd74a
https://pubmed.ncbi.nlm.nih.gov/31980965
https://pubmed.ncbi.nlm.nih.gov/31980965
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 43:85-98
In nonlinear mixed effect (NLME) modeling, the intra-individual variability is a collection of errors due to assay sensitivity, dosing, sampling, as well as model misspecification. Utilizing stochastic differential equations (SDE) within the NLME fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac13c77ac284b70a2412c19a7365111
https://doi.org/10.1007/s10928-015-9456-7
https://doi.org/10.1007/s10928-015-9456-7
Publikováno v:
IEEE Transactions on Biomedical Engineering. 62:1992-2000
The cardiovascular control system is continuously engaged to maintain homeostasis, but it is known to fail in a large cohort of patients suffering from orthostatic intolerance. Numerous clinical studies have been put forward to understand how the sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de16d8bfe777bdd6896d57ef0d55342a
https://doi.org/10.1109/tbme.2015.2409211
https://doi.org/10.1109/tbme.2015.2409211
Autor:
Brett Matzuka, Yoon Young Choi, Nigel J. Waters, Shanhu Hu, Graeme Hodgson, Kevin Dykstra, Emmanuelle di Tomaso, Kevin Sprott, Yixuan Ren, Christian Fritz, Chris Roberts
Publikováno v:
Molecular Cancer Therapeutics. 17:B171-B171
Introduction: CDK7 has recently emerged as an attractive gene control target in cancers driven by transcriptional dependencies, including triple-negative breast cancer (TNBC) and acute myeloid leukemia (AML). SY-1365 is a first-in-class, potent, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b13b093009f13cb9aa08ab0ff18cbf
https://doi.org/10.1158/1535-7163.targ-17-b171
https://doi.org/10.1158/1535-7163.targ-17-b171
Publikováno v:
Lecture Notes in Mathematics ISBN: 9783642328817
Filtering is a methodology used to combine a set of observations with a model to obtain the optimal state. This technique can be extended to estimate the state of the system as well as the unknown model parameters. Estimating the model parameters giv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d4cc5ac4582d71fa504ee3b7d4c742
https://doi.org/10.1007/978-3-642-32882-4_4
https://doi.org/10.1007/978-3-642-32882-4_4
Publikováno v:
EMBC
Online estimation of cerebral autoregulation (CA) may be advantageous in neurosurgical and neurointensive care units. Data from transcranial Doppler, and continuous arterial blood pressure are readily available at high temporal resolution and may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac3a4054d767389db5fbb143152435
https://pubmed.ncbi.nlm.nih.gov/22254827
https://pubmed.ncbi.nlm.nih.gov/22254827