Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Brett M. Stevens"'
Autor:
Amanda C. Winters, Mohd Minhajuddin, Brett M. Stevens, Ajay Major, Grace Bosma, Diana Abbott, Nicholas Miltgen, Ji Yuan, Amy L. Treece, Bradford J. Siegele, Mark D. Ewalt, Jonathan A. Gutman, Craig T. Jordan, Daniel A. Pollyea
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
Venetoclax with azacitidine (ven/aza) is a lower-intensity therapeutic regimen that has been shown to improve outcomes in elderly patients with acute myeloid leukemia (AML). Measurable residual disease (MRD) using flow cytometry is a valuable tool fo
Externí odkaz:
https://doaj.org/article/dd1f3941b21d43f7a99618a3961ccd30
Autor:
Rachel Culp-Hill, Brett M. Stevens, Courtney L. Jones, Shanshan Pei, Monika Dzieciatkowska, Mohammad Minhajuddin, Craig T. Jordan, Angelo D’Alessandro
Publikováno v:
Metabolites, Vol 13, Iss 4, p 467 (2023)
Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy
Externí odkaz:
https://doaj.org/article/65d7f53879dc4307ac50c0ab77af4dac
Autor:
Amanda C. Winters, Jonathan A. Gutman, Enkhtsetseg Purev, Molly Nakic, Jennifer Tobin, Stephanie Chase, Jeff Kaiser, Lindsey Lyle, Chelsey Boggs, Keri Halsema, Jeffrey T. Schowinsky, Julie Rosser, Mark D. Ewalt, Bradford Siegele, Vishal Rana, Steven Schuster, Diana Abbott, Brett M. Stevens, Craig T. Jordan, Clayton Smith, Daniel A. Pollyea
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 2911-2919 (2019)
Abstract: Venetoclax is approved for older untreated acute myeloid leukemia (AML) patients. Venetoclax was available prior to approval off-label. We assessed our single-institution off-label experience with venetoclax/azacitidine, comparing outcomes
Externí odkaz:
https://doaj.org/article/1934278e1f804e4f9fde48ee8377753e
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100248- (2021)
Summary: Isolation of leukemia stem cells presents a challenge due to the heterogeneity of the immunophenotypic markers commonly used to identify blood stem cells. Several studies have reported that relative levels of reactive oxygen species (ROS) ca
Externí odkaz:
https://doaj.org/article/b21bac2c3bff4bec873a355d6d5a660b
Autor:
Lorraine Davis, Zachary J. Walker, Denis Ohlstrom, Brett M. Stevens, Peter A. Forsberg, Tomer M. Mark, Craig T. Jordan, Daniel W. Sherbenou
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 54-54 (2022)
OBJECTIVES/GOALS: Immunomodulatory drugs (IMiDs) are critical to multiple myeloma (MM) disease control. IMiDs act by inducing Cereblon-dependent degradation of IKZF1 and IKZF3, which leads to IRF4 and MYC downregulation (collectively termed the “Ik
Externí odkaz:
https://doaj.org/article/f01e541e82b44b5ca415e89a489d9f7f
Autor:
Giovanny Hernandez, Taylor S. Mills, Jennifer L. Rabe, James S. Chavez, Susan Kuldanek, Gregory Kirkpatrick, Leila Noetzli, Widian K. Jubair, Michelle Zanche, Jason R. Myers, Brett M. Stevens, Courtney J. Fleenor, Biniam Adane, Charles A. Dinarello, John Ashton, Craig T. Jordan, Jorge Di Paola, James R. Hagman, V. Michael Holers, Kristine A. Kuhn, Eric M. Pietras
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberrant blood phenotypes including anemia and suppressed lymphopoiesis that
Externí odkaz:
https://doaj.org/article/eca59744a0444860b5057f8bf06972fb
Autor:
Brett M. Stevens, Nabilah Khan, Angelo D’Alessandro, Travis Nemkov, Amanda Winters, Courtney L. Jones, Wei Zhang, Daniel A. Pollyea, Craig T. Jordan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery an
Externí odkaz:
https://doaj.org/article/7232188cb74f401c89e6e1606e8171e9
Autor:
Biniam Adane, Haobin Ye, Nabilah Khan, Shanshan Pei, Mohammad Minhajuddin, Brett M. Stevens, Courtney L. Jones, Angelo D’Alessandro, Julie A. Reisz, Vadym Zaberezhnyy, Maura Gasparetto, Tzu-Chieh Ho, Kathleen K. Kelly, Jason R. Myers, John M. Ashton, Julie Siegenthaler, Tsutomu Kume, Eric L. Campbell, Daniel A. Pollyea, Michael W. Becker, Craig T. Jordan
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 238-254.e6 (2019)
Summary: The NADPH-dependent oxidase NOX2 is an important effector of immune cell function, and its activity has been linked to oncogenic signaling. Here, we describe a role for NOX2 in leukemia-initiating stem cell populations (LSCs). In a murine mo
Externí odkaz:
https://doaj.org/article/d5544c2b5ce54bd09d30079612acafba
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 5, Pp 723-736 (2013)
Abstract We found that basal‐like breast cancer (BLBC) cells use Cdc42 to inhibit function of the redox/Fyn/c‐Cbl (RFC) pathway, which normally functions to convert small increases in oxidative status into enhanced degradation of c‐Cbl target p
Externí odkaz:
https://doaj.org/article/c032c4fab12f437086dcb64f9a4469dc
Autor:
Craig T. Jordan, Clayton A. Smith, Michael R. Savona, Haley E. Ramsey, Jonathan A. Gutman, Angelo D'Alessandro, Travis Nemkov, John M. Ashton, Jason R. Myers, Andrew Hammes, Diana Abbott, Jeffrey Schowinsky, Jessica Ponder, Nabilah Khan, Biniam Adane, Courtney L. Jones, Anna Krug, Haobin Ye, Amanda Winters, Anagha Inguva, Maria L. Amaya, James C. Costello, Jihye Kim, Ryan M. Sheridan, Austin E. Gillen, Kent A. Riemondy, Rui Fu, Mohammad Minhajuddin, Brett M. Stevens, Annika Gustafson, Daniel A. Pollyea, Shanshan Pei
Venetoclax-based therapy can induce responses in approximately 70% of older previously untreated patients with acute myeloid leukemia (AML). However, up-front resistance as well as relapse following initial response demonstrates the need for a deeper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459448356d6d6a3954afc463053a8909
https://doi.org/10.1158/2159-8290.c.6547874.v1
https://doi.org/10.1158/2159-8290.c.6547874.v1
