Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brett M. Hirsch"'
Autor:
Marcus P. Wong, Michelle A. Meas, Cameron Adams, Samantha Hernandez, Valerie Green, Magelda Montoya, Brett M. Hirsch, Mary Horton, Hong L. Quach, Diana L. Quach, Xiaorong Shao, Indro Fedrigo, Alexandria Zermeno, Julia Huffaker, Raymond Montes, Alicia Madden, Sherri Cyrus, David McDowell, Phillip Williamson, Paul Contestable, Mars Stone, Josefina Coloma, Michael P. Busch, Lisa F. Barcellos, Eva Harris
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Serological surveillance studies of infectious diseases provide population-level estimates of infection and antibody prevalence, generating crucial insight into population-level immunity, risk factors leading to infection, and effectiveness
Externí odkaz:
https://doaj.org/article/7ffbe5d9f51f44ec9d0a6073b7d61e2f
Autor:
Mu Feng, Hilda Namanja-Magliano, Saranathan Rajagopalan, Tanmay Mishra, Rodrigo G. Ducati, Brett M. Hirsch, Libusha Kelly, Wendy Szymczak, Jorge Eduardo Fajardo, Simone Sidoli, Andras Fiser, William R. Jacobs, Vern L. Schramm
Publikováno v:
ACS Infect Dis
Helicobacter pylori is found in the gut lining of more than half of the world’s population, causes gastric ulcers, and contributes to stomach cancers. Menaquinone synthesis in H. pylori relies on the rare futalosine pathway, where H. pylori 5′-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3635ace2b7e600019f3bf720452a2955
https://doi.org/10.1021/acsinfecdis.2c00644
https://doi.org/10.1021/acsinfecdis.2c00644
Autor:
Raymond Montes, Brett M Hirsch, Xiaorong Shao, Cameron Adams, Hong Quach, Mary Horton, David McDowell, Samantha Hernandez, Phillip C. Williamson, Julia Huffaker, Magelda Montoya, Valerie Green, Diana Quach, Alicia Madden, Paul B. Contestable, Marcus P Wong, Indro Fedrigo, Sherri Cyrus, Josefina Coloma, Alexandria Zermeno, Michael P. Busch, Mars Stone, Eva Harris, Michelle Meas, Lisa F. Barcellos
Publikováno v:
Microbiology spectrum, vol 10, iss 3
Serological surveillance studies of infectious diseases provide population-level estimates of infection and antibody prevalence, generating crucial insight into population-level immunity, risk factors leading to infection, and effectiveness of public
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229af2c4616fe179cadf535dec9a5966
https://doi.org/10.1101/2021.11.25.21266786
https://doi.org/10.1101/2021.11.25.21266786
Autor:
Brett M. Hirsch, Lawrence Harris, Rodrigo G. Ducati, Rajesh K. Harijan, Gary B. Evans, Vern L. Schramm
Publikováno v:
ACS Chemical Biology. 13:152-160
Phosphoribosyl transferases (PRTs) are essential in nucleotide synthesis and salvage, amino acid, and vitamin synthesis. Transition state analysis of several PRTs has demonstrated ribocation-like transition states with a partial positive charge resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c34da0e2e34ec6f7850ac8dde892d2
https://doi.org/10.1021/acschembio.7b00601
https://doi.org/10.1021/acschembio.7b00601
Autor:
Ross S. Firestone, Rajesh K. Harijan, Oskar Hoff, Vern L. Schramm, Peter C. Tyler, Rodrigo G. Ducati, Brett M. Hirsch, Gary B. Evans
Bacterial 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase (MTAN) hydrolyzes adenine from its substrates to form S-methyl-5-thioribose and S-ribosyl-l-homocysteine. MTANs are involved in quorum sensing, menaquinone synthesis, and 5'-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0521aeabf7d963a5300722b616e2b534
https://europepmc.org/articles/PMC6635953/
https://europepmc.org/articles/PMC6635953/
Publikováno v:
ACS Chemical Biology
Macrodomains, including the human macrodomain 1 (MacroD1), are erasers of the post-translational modification of monoadenosinediphospho-ribosylation and hydrolytically deacetylate the sirtuin product O-acetyl-ADP-ribose (OAADPr). OAADPr has been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351bc3033e8f5870d9c1d16c3ba2895f
https://doi.org/10.1021/cb500485w
https://doi.org/10.1021/cb500485w
Autor:
Weiping Zheng, Brett M. Hirsch
Publikováno v:
Mol. BioSyst.. 7:16-28
Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein deacetylases that can catalyze the β-nicotinamide adenine dinucleotide (β-NAD(+))-dependent deacetylation of N(ε)-acetyl-lysine on protein substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff13381fba6f69b9bb972b9783712f
https://doi.org/10.1039/c0mb00033g
https://doi.org/10.1039/c0mb00033g
Publikováno v:
Bioorganic Chemistry. 38:17-25
Peptides containing L-N(epsilon)-acetyl-lysine (L-AcK) or its side chain modified analogs were prepared and assayed using SIRT1, the prototypical human silent information regulator 2 (Sir2) enzyme. While previous studies showed that the side chain ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee4c8edbdcdbc40d40e223c6e67c6af
https://doi.org/10.1016/j.bioorg.2009.10.001
https://doi.org/10.1016/j.bioorg.2009.10.001
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(16)
In the current study, we have identified N(ε)-thiocarbamoyl-lysine (TuAcK) as a general sirtuin inhibitory warhead which was shown to be able to confer potent sirtuin inhibition. This inhibition was also shown to be mechanism-based in that the TuAck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04120cc0cd384a46a243a2ccfde5c0a2
https://pubmed.ncbi.nlm.nih.gov/21752644
https://pubmed.ncbi.nlm.nih.gov/21752644
Autor:
Chrys Wesdemiotis, Jorge A. Sylvester, Brett M. Hirsch, Weiping Zheng, Zhanwen Du, Zhenghe Wang, Xiaopeng Li
Publikováno v:
MedChemComm. 2:291
Inhibitors of sirtuin-catalyzed NAD+-dependent proteinlysine deacetylation reaction possess great value for a fuller exploration of sirtuin biology/pharmacology and as potential therapeutic agents for metabolic and age-related diseases and cancer. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f58e89dcdc0fdae75b8c96023f3ec3
https://doi.org/10.1039/c0md00212g
https://doi.org/10.1039/c0md00212g