Výsledky vyhledávání - "Brett M Stevens"

Akademický článek

Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine

Autor: Amanda C. Winters, Mohd Minhajuddin, Brett M. Stevens, Ajay Major, Grace Bosma, Diana Abbott, Nicholas Miltgen, Ji Yuan, Amy L. Treece, Bradford J. Siegele, Mark D. Ewalt, Jonathan A. Gutman, Craig T. Jordan, Daniel A. Pollyea

Publikováno v: Haematologica, Vol 109, Iss 6 (2023)

Venetoclax with azacitidine (ven/aza) is a lower-intensity therapeutic regimen that has been shown to improve outcomes in elderly patients with acute myeloid leukemia (AML). Measurable residual disease (MRD) using flow cytometry is a valuable tool fo

Externí odkaz: https://doaj.org/article/dd1f3941b21d43f7a99618a3961ccd30

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Akademický článek

Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2

Autor: Rachel Culp-Hill, Brett M. Stevens, Courtney L. Jones, Shanshan Pei, Monika Dzieciatkowska, Mohammad Minhajuddin, Craig T. Jordan, Angelo D’Alessandro

Publikováno v: Metabolites, Vol 13, Iss 4, p 467 (2023)

Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy

Externí odkaz: https://doaj.org/article/65d7f53879dc4307ac50c0ab77af4dac

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Akademický článek

Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia

Publikováno v: Blood Advances, Vol 3, Iss 20, Pp 2911-2919 (2019)

Abstract: Venetoclax is approved for older untreated acute myeloid leukemia (AML) patients. Venetoclax was available prior to approval off-label. We assessed our single-institution off-label experience with venetoclax/azacitidine, comparing outcomes

Externí odkaz: https://doaj.org/article/1934278e1f804e4f9fde48ee8377753e

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Akademický článek

Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting

Autor: Brett M. Stevens, Cristiana O’Brien, Craig T. Jordan, Courtney L. Jones

Publikováno v: STAR Protocols, Vol 2, Iss 1, Pp 100248- (2021)

Summary: Isolation of leukemia stem cells presents a challenge due to the heterogeneity of the immunophenotypic markers commonly used to identify blood stem cells. Several studies have reported that relative levels of reactive oxygen species (ROS) ca

Externí odkaz: https://doaj.org/article/b21bac2c3bff4bec873a355d6d5a660b

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Akademický článek

309 MYC Inhibition Overcomes IMiD Resistance in Heterogeneous Multiple Myeloma Populations

Autor: Lorraine Davis, Zachary J. Walker, Denis Ohlstrom, Brett M. Stevens, Peter A. Forsberg, Tomer M. Mark, Craig T. Jordan, Daniel W. Sherbenou

Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 54-54 (2022)

OBJECTIVES/GOALS: Immunomodulatory drugs (IMiDs) are critical to multiple myeloma (MM) disease control. IMiDs act by inducing Cereblon-dependent degradation of IKZF1 and IKZF3, which leads to IRF4 and MYC downregulation (collectively termed the “Ik

Externí odkaz: https://doaj.org/article/f01e541e82b44b5ca415e89a489d9f7f

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Akademický článek

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

Publikováno v: Haematologica, Vol 105, Iss 3 (2020)

Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberrant blood phenotypes including anemia and suppressed lymphopoiesis that

Externí odkaz: https://doaj.org/article/eca59744a0444860b5057f8bf06972fb

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Akademický článek

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

Autor: Brett M. Stevens, Nabilah Khan, Angelo D’Alessandro, Travis Nemkov, Amanda Winters, Courtney L. Jones, Wei Zhang, Daniel A. Pollyea, Craig T. Jordan

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery an

Externí odkaz: https://doaj.org/article/7232188cb74f401c89e6e1606e8171e9

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Akademický článek

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

Publikováno v: Cell Reports, Vol 27, Iss 1, Pp 238-254.e6 (2019)

Summary: The NADPH-dependent oxidase NOX2 is an important effector of immune cell function, and its activity has been linked to oncogenic signaling. Here, we describe a role for NOX2 in leukemia-initiating stem cell populations (LSCs). In a murine mo

Externí odkaz: https://doaj.org/article/d5544c2b5ce54bd09d30079612acafba

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