Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Brett M Paterson"'
Autor:
Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, Anthony R White
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90070 (2014)
Abnormal biometal homeostasis is a central feature of many neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease. Recent studies have shown that metal complexing compounds behaving as ionop
Externí odkaz:
https://doaj.org/article/5344d4ebcc43491a8a4ad0efaafde9ce
Autor:
Katja M Kanninen, Alexandra Grubman, Jodi Meyerowitz, Clare Duncan, Jiang-Li Tan, Sarah J Parker, Peter J Crouch, Brett M Paterson, James L Hickey, Paul S Donnelly, Irene Volitakis, Imke Tammen, David N Palmer, Anthony R White
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58644 (2013)
Mutations in the CLN6 gene cause a variant late infantile form of neuronal ceroid lipofuscinosis (NCL; Batten disease). CLN6 loss leads to disease clinically characterized by vision impairment, motor and cognitive dysfunction, and seizures. Accumulat
Externí odkaz:
https://doaj.org/article/ab28937cb16247ea8602d2fcbf29fd16
Autor:
Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, SinChun Lim, Brett M Paterson, Paul S Donnelly, Peter J Crouch, Anthony R White
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42277 (2012)
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, motor neuron disease with no effective long-term treatment options. Recently, TDP-43 has been identified as a key protein in the pathogenesis of some cases of ALS. Although the role of TDP-
Externí odkaz:
https://doaj.org/article/3b5512010cb641b9b53449d57880b60f
Publikováno v:
Molecules, Vol 28, Iss 1, p 203 (2022)
The positron-emitting radionuclide gallium-68 has become increasingly utilised in both preclinical and clinical settings with positron emission tomography (PET). The synthesis of radiochemically pure gallium-68 radiopharmaceuticals relies on careful
Externí odkaz:
https://doaj.org/article/bb97ba369ab34f0282e93869209124af
Autor:
Katherine A. Morgan, Michael de Veer, Luke A. Miles, Cormac A. A. Kelderman, Catriona A. McLean, Colin L. Masters, Kevin J. Barnham, Jonathan M. White, Brett M. Paterson, Paul S. Donnelly
Publikováno v:
Chemical Communications. 59:2243-2246
Amyloid-β antibodies were modified to incorporate trans-cyclooctene functional groups. Radiolabeled copper-64 probes, which can cross the blood–brain barrier and contain a 1,2,4,5-tetrazine functional group, react with the modified antibodies.
Autor:
Sanjeevini Babu Reddiar, Michael de Veer, Brett M. Paterson, Tara Sepehrizadeh, Dorothy C. C. Wai, Agota Csoti, Gyorgy Panyi, Joseph A. Nicolazzo, Raymond S. Norton
Publikováno v:
Molecular Pharmaceutics. 20:255-266
The voltage-gated potassium channel Kv1.3 regulates the pro-inflammatory function of microglia and is highly expressed in the post-mortem brains of individuals with Alzheimer's and Parkinson's diseases. HsTX1[R14A] is a selective and potent peptide i
Publikováno v:
Molecules, Vol 26, Iss 12, p 3646 (2021)
A 1,4,7,10-tetraazacyclododecane (cyclen) variant bearing two thiosemicarbazone pendant groups has been prepared. The ligand forms complexes with Mn2+, Co2+ and Zn2+. X-ray crystallography of the Mn2+, Co2+ and Zn2+ complexes showed that the ligand p
Externí odkaz:
https://doaj.org/article/c336d4fe181e45dab623a9c0af75594d
Publikováno v:
Australian Journal of Chemistry. 75:631-635
The synthesis and structural characterisation of an icosanuclear silver(I) cluster complex is reported here. The complex includes twenty silver(I) ions supported by eighteen bis(thiosemicarbazonato) ligands. The cluster of silver(I) ions involves sev
Autor:
Cormac A. A. Kelderman, Patrick R. W. J. Davey, Michelle T. Ma, Michael de Veer, Ekaterina Salimova, Paul S. Donnelly, Brett M. Paterson
Publikováno v:
Dalton Transactions. 51:14064-14078
The syntheses of non-oxido/non-nitrido bis(thiosemicarbazonato)technetium(V) complexes featuring a series of alkyl and ether substituents is presented. The bis(thiosemicarbazones) were radiolabelled with technetium-99m using an optimised one-pot synt
Autor:
Brett M Paterson, Melyssa Grieve
Publikováno v:
Australian Journal of Chemistry. 75:65-88
Several radiometals are of interest in the development of new α-emitting radiopharmaceuticals. This review highlights the role of coordination chemistry in the design of 225Ac, 212/213Bi, 212Pb, 149Tb, 227Th, and 223/224Ra radiopharmaceuticals to tr