Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Brett M Collins"'
Autor:
Rebeka Butkovič, Alexander P. Walker, Michael D. Healy, Kerrie E. McNally, Meihan Liu, Tineke Veenendaal, Kohji Kato, Nalan Liv, Judith Klumperman, Brett M. Collins, Peter J. Cullen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo proteins are selected fo
Externí odkaz:
https://doaj.org/article/85deafa608c9468da12e9b3d0fe09ce1
Autor:
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113460- (2023)
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) rec
Externí odkaz:
https://doaj.org/article/4474e4516773492c91d72485b72ad7d7
Autor:
Yue Wu, Zhenling Cui, Yen-Hua Huang, Simon J. de Veer, Andrey V. Aralov, Zhong Guo, Shayli V. Moradi, Alexandra O. Hinton, Jennifer R. Deuis, Shaodong Guo, Kai-En Chen, Brett M. Collins, Irina Vetter, Volker Herzig, Alun Jones, Matthew A. Cooper, Glenn F. King, David J. Craik, Kirill Alexandrov, Sergey Mureev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Generic approach for rapid prototyping is essential for the progress of synthetic biology. Here the authors modify the cell-free translation system to control protein aggregation and folding and validate the approach by using single conditions for pr
Externí odkaz:
https://doaj.org/article/4f078ffc82bf47b0b496a47fa5dcdbdc
Autor:
Vikas A. Tillu, James Rae, Ya Gao, Nicholas Ariotti, Matthias Floetenmeyer, Oleksiy Kovtun, Kerrie-Ann McMahon, Natasha Chaudhary, Robert G. Parton, Brett M. Collins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Caveolae are spherical nanodomains of the plasma membrane generated by assembly of caveolin and cavin proteins. Here, the authors show that fuzzy electrostatic interactions between caveolin-1 and Cavin1 proteins, combined with membrane lipid interact
Externí odkaz:
https://doaj.org/article/2807bb40181f4244bd067fd1cb562ab3
Autor:
Gagan Sharma, Carolyne B. Braga, Kai-En Chen, Xinying Jia, Venkatraman Ramanujam, Brett M. Collins, Roberto Rittner, Mehdi Mobli
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 179-186 (2021)
Chlorotoxin (ClTx) is a 36-residue disulfide-rich peptide isolated from the venom of the scorpion Leiurus quinquestriatus. This peptide has been shown to selectively bind to brain tumours (gliomas), however, with conflicting reports regarding its dir
Externí odkaz:
https://doaj.org/article/af52d3404ddf4994b4ff881afbc923be
Autor:
Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001601 (2022)
Coat complexes coordinate cargo recognition through cargo adaptors with biogenesis of transport carriers during integral membrane protein trafficking. Here, we combine biochemical, structural, and cellular analyses to establish the mechanistic basis
Externí odkaz:
https://doaj.org/article/844881cd71af4ba98857830ac0cd310b
Autor:
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from
Externí odkaz:
https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f
Autor:
Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne, Brett M. Collins
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Recent advances in protein structure prediction using machine learning such as AlphaFold2 and RosettaFold presage a revolution in structural biology. Genome-wide predictions of protein structures are providing unprecedented insights into their archit
Externí odkaz:
https://doaj.org/article/b0c755485d2f403b8d0b3e36c808e9ef
Autor:
Kirsty J McMillan, Paul J Banks, Francesca LN Hellel, Ruth E Carmichael, Thomas Clairfeuille, Ashley J Evans, Kate J Heesom, Philip Lewis, Brett M Collins, Zafar I Bashir, Jeremy M Henley, Kevin A Wilkinson, Peter J Cullen
Publikováno v:
eLife, Vol 10 (2021)
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies,
Externí odkaz:
https://doaj.org/article/37f2888d4612454586ef6c3bee532043
Autor:
Ian R. Monk, Nausad Shaikh, Stephanie L. Begg, Mike Gajdiss, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M. Collins, Gabriele Bierbaum, Saumya R. Udagedara, Jacqueline R. Morey, Neha Pulyani, Benjamin P. Howden, Megan J. Maher, Christopher A. McDevitt, Glenn F. King, Timothy P. Stinear
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhi
Externí odkaz:
https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11