Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brett M Antonio"'
Autor:
Talia A. Atkin, Chani M. Maher, Aaron C. Gerlach, Bryant C. Gay, Brett M. Antonio, Sonia C. Santos, Karen M. Padilla, JulieAnn Rader, Douglas S. Krafte, Matthew A. Fox, Gregory R. Stewart, Slavé Petrovski, Orrin Devinsky, Matthew Might, Steven Petrou, David B. Goldstein
Publikováno v:
Epilepsia. 59:802-813
Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds. Here, we demonstrate the feasibility of a more comprehensive approach using high-throughput screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4638535ade3ab31dcb318a2a03aba8f7
https://doi.org/10.1111/epi.14037
https://doi.org/10.1111/epi.14037
Autor:
Christopher William West, Nigel Alan Swain, Peter J. Cox, Joseph S. Warmus, Kiyoyuki Omoto, David C. Pryde, George Salvatore Amato, Steven Michael Reister, Jamie Turner, Brett M Antonio, Aaron C. Gerlach, Brian E. Marron, Karen Padilla, Katrina Yoger, John H. Mahoney
Publikováno v:
ACS Medicinal Chemistry Letters. 8:666-671
A series of TRPA1 antagonists is described which has as its core structure an indazole moiety. The physical properties and in vitro DMPK profiles are discussed. Good in vivo exposure was obtained with several analogs, allowing efficacy to be assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a69bdcd2bd38c2563a5531fab1a88
https://doi.org/10.1021/acsmedchemlett.7b00140
https://doi.org/10.1021/acsmedchemlett.7b00140
Autor:
Sean, Ekins, Jacob, Gerlach, Kimberley M, Zorn, Brett M, Antonio, Zhixin, Lin, Aaron, Gerlach
Publikováno v:
Pharm Res
PURPOSE: Pitt Hopkins Syndrome (PTHS) is a rare genetic disorder caused by mutations of a specific gene, transcription factor 4 (TCF4), located on chromosome 18. PTHS results in individuals that have moderate to severe intellectual disability, with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1610a7973f5a395b11f4286ce43366b
https://pubmed.ncbi.nlm.nih.gov/31332533
https://pubmed.ncbi.nlm.nih.gov/31332533
Autor:
Rosemarie Roeloffs, Anthony W Bannon, Adam R. Brown, Alexandre J.C. Loucif, Aristos J. Alexandrou, Anthony J. Kirkup, Mathew D Fuller, Gillian Stockbridge, Edward B. Stevens, David Printzenhoff, Praveen Anand, Steve England, Claire Elizabeth Payne, Uma Anand, Peter J. Bungay, Aaron C. Gerlach, Mark L. Chapman, Kemp Mark Ian, John H. Mahoney, Rebecca L. Prime, Jonathon W Theile, Brett M Antonio, Richard P. Butt, Sharan K. Bagal
Publikováno v:
British Journal of Pharmacology. 172:2654-2670
Background and Purpose NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc8c0db0b158b8bf6fded6eb148ad000
https://doi.org/10.1111/bph.13092
https://doi.org/10.1111/bph.13092
Autor:
Alexandre J C, Loucif, Pierre-Philippe, Saintot, Jia, Liu, Brett M, Antonio, Shannon G, Zellmer, Katrina, Yoger, Emma L, Veale, Anna, Wilbrey, Kiyoyuki, Omoto, Lishuang, Cao, Alex, Gutteridge, Neil A, Castle, Edward B, Stevens, Alistair, Mathie
Publikováno v:
British Journal of Pharmacology
Background and Purpose TREK two‐pore‐domain potassium (K2P) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc51147cd345d23353ed9c510e224600
https://pubmed.ncbi.nlm.nih.gov/29150838
https://pubmed.ncbi.nlm.nih.gov/29150838
Autor:
Zhixin Lin, Mark L. Chapman, Christopher William West, Neil A. Castle, Stupple Paul Anthony, P. Kay Wagoner, Brett M Antonio, Marcel J. de Groot, Brian E. Marron, Richard P. Butt, Nigel Alan Swain, Ken McCormack, Sonia Santos, Shannon G. Zellmer, David Printzenhoff, Karen Padilla, Michael J. Krambis, Douglas S. Krafte
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Voltage-gated sodium (Nav) channels play a fundamental role in the generation and propagation of electrical impulses in excitable cells. Here we describe two unique structurally related nanomolar potent small molecule Nav channel inhibitors that exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5827f9ae8e9e8c34d877f50ece8e447e
https://doi.org/10.1073/pnas.1220844110
https://doi.org/10.1073/pnas.1220844110