Výsledky vyhledávání - "Brett Lindenbach"

Akademický článek

De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)

Here, the authors identify and validate the emergence of a SARS-CoV-2 resistance mutation to Remdesivir, associated with virological recrudesce in an immunocompromised patient with persistent COVID-19.

Externí odkaz: https://doaj.org/article/9b3a77f831774145b06a422bbfb8f3de

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Akademický článek

Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV‑2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

Autor: Chun-Hui Zhang, Elizabeth A. Stone, Maya Deshmukh, Joseph A. Ippolito, Mohammad M. Ghahremanpour, Julian Tirado-Rives, Krasimir A. Spasov, Shuo Zhang, Yuka Takeo, Shalley N. Kudalkar, Zhuobin Liang, Farren Isaacs, Brett Lindenbach, Scott J. Miller, Karen S. Anderson, William L. Jorgensen

Publikováno v: ACS Central Science, Vol 7, Iss 3, Pp 467-475 (2021)

Externí odkaz: https://doaj.org/article/21f39d6febba495a8aac30e488fc3ee5

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Akademický článek

Erratum for Barouch-Bentov et al., 'Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment'

Autor: Rina Barouch-Bentov, Gregory Neveu, Fei Xiao, Melanie Beer, Elena Bekerman, Stanford Schor, Joseph Campbell, Jim Boonyaratanakornkit, Brett Lindenbach, Albert Lu, Yves Jacob, Shirit Einav

Publikováno v: mBio, Vol 9, Iss 1 (2018)

Externí odkaz: https://doaj.org/article/7bbed2e53a614c978049c247a9385a33

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Akademický článek

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.

Autor: Solène Denolly, Chloé Mialon, Thomas Bourlet, Fouzia Amirache, François Penin, Brett Lindenbach, Bertrand Boson, François-Loïc Cosset

Publikováno v: PLoS Pathogens, Vol 13, Iss 12, p e1006774 (2017)

Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and se

Externí odkaz: https://doaj.org/article/6332dca7421e46b5a8ca1a9ea2a1234b

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Akademický článek

Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment

Autor: Rina Barouch-Bentov, Gregory Neveu, Fei Xiao, Melanie Beer, Elena Bekerman, Stanford Schor, Joseph Campbell, Jim Boonyaratanakornkit, Brett Lindenbach, Albert Lu, Yves Jacob, Shirit Einav

Publikováno v: mBio, Vol 7, Iss 6 (2016)

ABSTRACT Enveloped viruses commonly utilize late-domain motifs, sometimes cooperatively with ubiquitin, to hijack the endosomal sorting complex required for transport (ESCRT) machinery for budding at the plasma membrane. However, the mechanisms under

Externí odkaz: https://doaj.org/article/7638b83bba084ee190baf218083848bc

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Akademický článek

Genome-wide analysis of host factors in nodavirus RNA replication.

Autor: Linhui Hao, Brett Lindenbach, Xiaofeng Wang, Billy Dye, David Kushner, Qiuling He, Michael Newton, Paul Ahlquist

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95799 (2014)

Flock House virus (FHV), the best studied of the animal nodaviruses, has been used as a model for positive-strand RNA virus research. As one approach to identify host genes that affect FHV RNA replication, we performed a genome-wide analysis using a

Externí odkaz: https://doaj.org/article/d2ef1c91592647859c94abb001c2586c

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Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

Autor: Theresa Bub, Virginia Hargest, Shaoyuan Tan, Maria Smith, Ana Vazquez-Pagan, Tim Flerlage, Pamela H. Brigleb, Victoria Meliopoulos, Brett Lindenbach, Valerie Cortez, Jeremy Chase Crawford, Stacey Schultz-Cherry

Publikováno v: bioRxiv

Human astrovirus is a positive sense, single stranded RNA virus. Astrovirus infection causes gastrointestinal symptoms and can lead to encephalitis in immunocompromised patients. Positive strand RNA viruses typically utilize host intracellular membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09315b9f2b74a0f3b80161bd4c66ec64
https://europepmc.org/articles/PMC10120637/

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De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report

Publikováno v: medRxiv

SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We present a case of an immunocompromised patient with acquired B-cell deficiency who develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf4397310e5746883f19c768afd0313
https://pubmed.ncbi.nlm.nih.gov/34909781

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