Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brett L. Roberts"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100288- (2021)
Summary: The discovery of potent cell-permeable E3 ubiquitin ligase ligands can significantly facilitate the development of proteolysis targeting chimeras (PROTACs). Here, we present a protocol to determine the binding affinity of ligands toward CRBN
Externí odkaz:
https://doaj.org/article/c8bc3e6b44b3466b8d858f95e62d265d
Autor:
Haibo Xie, Chunrong Li, Hua Tang, Ira Tandon, Junzhuo Liao, Brett L. Roberts, Yu Zhao, Weiping Tang
Publikováno v:
Journal of Medicinal Chemistry. 66:2904-2917
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb9be83e0bb5e72ebdf71664c7a3bce
https://doi.org/10.1021/acs.jmedchem.2c01941
https://doi.org/10.1021/acs.jmedchem.2c01941
Publikováno v:
ACS Chemical Biology. 15:1487-1496
Proteolysis targeting chimeras (PROTACs) have emerged as useful chemical probes and potential therapeutics by taking advantage of the ubiquitin-proteasome system to degrade intracellular disease-associated proteins. PROTACs are heterobifunctional mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49367bc911d818d742541ec675560a55
https://doi.org/10.1021/acschembio.0c00140
https://doi.org/10.1021/acschembio.0c00140
Autor:
William J. Reddig, Si Wu, Shawna J. Standke, Zhibo Yang, Brett L Roberts, Hongyan Ma, Juan I. Nuñez, Earl L. Blewett, Anh T. Le, Naga Rama Kothapalli, Zachary C. Severance, Ryan C Bensen, Anthony W. G. Burgett
Publikováno v:
ACS Chemical Biology
Oxysterol-binding protein (OSBP) is a lipid transport and regulatory protein required for the replication of Enterovirus genus viruses, which includes many significant human pathogens. Short-term exposure (i.e., 1-6 h) to a low dose (i.e., 1 nM) of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387ae8842fc9684f2a2cab6c9fa46e0b
https://doi.org/10.1021/acschembio.8b00984
https://doi.org/10.1021/acschembio.8b00984
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100288-(2021)
STAR Protocols
STAR Protocols
Summary The discovery of potent cell-permeable E3 ubiquitin ligase ligands can significantly facilitate the development of proteolysis targeting chimeras (PROTACs). Here, we present a protocol to determine the binding affinity of ligands toward CRBN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcacb869ddf84a30217afe7058a15d1
http://www.sciencedirect.com/science/article/pii/S2666166720302756
http://www.sciencedirect.com/science/article/pii/S2666166720302756
Autor:
Brett L Roberts, Xiaolei Li, Ka Yang, Daniel A. Glazier, Junzhuo Liao, Christopher M Stevens, Weiping Tang
Publikováno v:
Bioconjugate chemistry. 31(5)
RNA plays a myriad of roles in the body including the coding, decoding, regulation, and expression of genes. RNA oligonucleotides have garnered significant interest as therapeutics via antisense oligonucleotides or small interfering RNA strategies fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c11779a522a2aafc7b0cbd3d3ac6c2b
https://pubmed.ncbi.nlm.nih.gov/32227878
https://pubmed.ncbi.nlm.nih.gov/32227878
Autor:
Juan I. Nuñez, Earl L. Blewett, Brett L Roberts, Ryan C Bensen, Zachary C. Severance, Anthony W. G. Burgett, Cori A. Malinky, Anh T. Le-McClain, William J. Reddig, Evan M. Mettenbrink
Publikováno v:
Antiviral research. 170
Oxysterol-binding Protein (OSBP) is a human lipid-transport protein required for the cellular replication of many types of viruses, including several human pathogens. The structurally-diverse small molecule compounds OSW-1, itraconazole (ITZ), T-0012
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0db702d492da8293ba4ef327e39e43d
https://pubmed.ncbi.nlm.nih.gov/31271764
https://pubmed.ncbi.nlm.nih.gov/31271764