Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Brett G. M. Hughes"'
Autor:
Byoung Chul Cho, Irene Braña, Beatriz Cirauqui, Sercan Aksoy, Felix Couture, Ruey-Long Hong, Wilson H. Miller, Manuel Chaves-Conde, Margarida Teixeira, Lance Leopold, Mihaela Munteanu, Joy Yang Ge, Ramona F. Swaby, Brett G. M. Hughes
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-12 (2024)
Abstract Background Advanced head and neck squamous cell carcinoma (HNSCC) has a poor prognosis, and new treatment options are needed. Combining immunotherapies with differing mechanisms of action may enhance clinical benefits compared with single-ag
Externí odkaz:
https://doaj.org/article/24bfd93adc7946a58a1c047c4d340cb7
Autor:
Åse Bratland, Eva Munoz-Couselo, Laurent Mortier, Osama Roshdy, Rene González, Jacob Schachter, Ana M. Arance, Florent Grange, Nicolas Meyer, Abhishek Jagdish Joshi, Salem Billan, Brett G. M. Hughes, Jean-Jacques Grob, Karthik Ramakrishnan, Joy Ge, Burak Gumuscu, Ramona F. Swaby, Ralf Gutzmer
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 12, Pp 3165-3180 (2023)
Abstract Introduction At first interim analysis of KEYNOTE-629, health-related quality of life (HRQoL) with pembrolizumab was stable or improved over 48 weeks in recurrent or metastatic (R/M) cutaneous squamous cell carcinoma (cSCC). HRQoL results fr
Externí odkaz:
https://doaj.org/article/c25ae9485a674062bd066049630a8b43
Autor:
Matthew H. Taylor, Sophie Leboulleux, Yury Panaseykin, Bhavana Konda, Christelle de LaFouchardiere, Brett G. M. Hughes, Andrew G. Gianoukakis, Young Joo Park, Ilia Romanov, Monika K. Krzyzanowska, Diana Garbinsky, Bintu Sherif, Jie Janice Pan, Terri A. Binder, Nicholas Sauter, Ran Xie, Marcia S. Brose
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4332-4342 (2023)
Abstract Background In the phase 2 double‐blind Study 211, a starting dose of lenvatinib 18 mg/day was compared with the approved starting dose of 24 mg/day in patients with radioiodine‐refractory differentiated thyroid cancer (RR‐DTC). Predefi
Externí odkaz:
https://doaj.org/article/dc0ec1a8bab345c086c5e789e1eef9a5
Autor:
Habib Sadeghirad, Ning Liu, James Monkman, Ning Ma, Bassem Ben Cheikh, Niyati Jhaveri, Chin Wee Tan, Majid Ebrahimi Warkiani, Mark N. Adams, Quan Nguyen, Rahul Ladwa, Oliver Braubach, Ken O’Byrne, Melissa Davis, Brett G. M. Hughes, Arutha Kulasinghe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint inhibitors (ICIs) have shown promising results in patients with recurrent or metasta
Externí odkaz:
https://doaj.org/article/deb6e95791cc45ce81a3059cd2e13bb7
Autor:
Habib Sadeghirad, James Monkman, Ahmed M. Mehdi, Rahul Ladwa, Ken O’Byrne, Brett G. M. Hughes, Arutha Kulasinghe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Head and neck squamous cell carcinoma (HNSCC) often presents with locoregional or distant disease, despite multimodal therapeutic approaches, which include surgical resection, chemoradiotherapy, and more recently, immunotherapy for metastatic or recu
Externí odkaz:
https://doaj.org/article/5034624ca5ae444e9dd5babcf7d03a81
Autor:
Elizabeth Ahern, Annette Cubitt, Emma Ballard, Michele W. L. Teng, William C. Dougall, Mark J. Smyth, David Godbolt, Rishendran Naidoo, Amanda Goldrick, Brett G. M. Hughes
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Neoadjuvant immunotherapy targeting immune checkpoint programmed death-1 (PD-1) is under investigation in various tumour settings including non-small-cell lung cancer (NSCLC). Preclinical models demonstrate the superior power of t
Externí odkaz:
https://doaj.org/article/9117ce33194c46a382e8341cd7f4cfdf
Autor:
Arutha Kulasinghe, Touraj Taheri, Ken O’Byrne, Brett G. M. Hughes, Liz Kenny, Chamindie Punyadeera
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
BackgroundImmune checkpoint inhibitors (ICI) have shown durable and long-term benefits in a subset of head and neck squamous cell carcinoma (HNSCC) patients. To identify patient-responders from non-responders, biomarkers are needed which are predicti
Externí odkaz:
https://doaj.org/article/6a213bef28fb44878855ffa65fbaa711
Autor:
Kai Dun Tang, Sarju Vasani, Touraj Taheri, Laurence J. Walsh, Brett G. M. Hughes, Lizbeth Kenny, Chamindie Punyadeera
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, ther
Externí odkaz:
https://doaj.org/article/3df7c6736d2049c3823de5e2958eab87
Autor:
Yingying Jiang, Yue Shi, Yiling Liu, Zihan Wang, Yuxin Ma, Xinhong Shi, Lin Lu, Zhitong Wang, Hang Li, Yushu Zhang, Caolu Liu, Shaorui Zhang, Zhihao Zhong, Jianwei Lu, Meiqi Shi, Bo Shen, Guoren Zhou, Rong Yin, Domenico Galetta, Anna Grenda, Atocha Romero, Brett G. M. Hughes, Cheng Chen, Xiaohua Wang, Jifeng Feng
Publikováno v:
Translational Lung Cancer Research. 11:2521-2538
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c755f675fd3135846510608e4d46990e
https://doi.org/10.21037/tlcr-22-857
https://doi.org/10.21037/tlcr-22-857
Publikováno v:
Advances in Nutrition. 13:2433-2444
Sarcopenia is a known independent prognostic factor for decreased survival in patients with head and neck cancer, yet its importance for the growing number of younger patients diagnosed with human papillomavirus (HPV) positive oropharyngeal carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06abc20813a84242286abc6bc8652d9f
https://doi.org/10.1093/advances/nmac076
https://doi.org/10.1093/advances/nmac076