Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Brett G. Hollier"'
Autor:
Smriti Chawla, Anja Rockstroh, Melanie Lehman, Ellca Ratther, Atishay Jain, Anuneet Anand, Apoorva Gupta, Namrata Bhattacharya, Sarita Poonia, Priyadarshini Rai, Nirjhar Das, Angshul Majumdar, Jayadeva, Gaurav Ahuja, Brett G. Hollier, Colleen C. Nelson, Debarka Sengupta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Predicting treatment response in cancer remains a highly complex task. Here, the authors develop Precily, a deep neural network framework to predict treatment response in cancer by considering gene expression, pathway activity estimates and drug feat
Externí odkaz:
https://doaj.org/article/02a9dee061714a6ca6f4b672374147c3
Autor:
Yu Hin Tang, Anja Rockstroh, Kamil A. Sokolowski, Layla-Rose Lynam, Melanie Lehman, Erik W. Thompson, Philip A. Gregory, Colleen C. Nelson, Marianna Volpert, Brett G. Hollier
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-17 (2022)
Abstract Background Triple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 and 39% of TNBCs are claudin-low, a poorly differentiated subtype enriched for mesenchymal, stem cell and mitog
Externí odkaz:
https://doaj.org/article/684155e1b55647e9a6a13d4ab5bc7d5f
Autor:
Phoebe L. Sarkar, Wendy Lee, Elizabeth D. Williams, Amy A. Lubik, Nataly Stylianou, Ali Shokoohmand, Melanie L. Lehman, Brett G. Hollier, Jennifer H. Gunter, Colleen C. Nelson
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer (PCa), yet many patients relapse with lethal metastatic disease. With this loss of androgens, increased cell plasticity has been observed as an adaptive respons
Externí odkaz:
https://doaj.org/article/698d511671a7433ebdb514ff6f6cc51c
Autor:
Malina Xiao, Meriem Hasmim, Audrey Lequeux, Kris Van Moer, Tuan Zea Tan, Christine Gilles, Brett G. Hollier, Jean Paul Thiery, Guy Berchem, Bassam Janji, Muhammad Zaeem Noman
Publikováno v:
Cancers, Vol 13, Iss 5, p 1165 (2021)
CMTM6 is a critical regulator of cell surface expression of PD-L1 in tumor cells, but little is known about the transcriptional regulation of CMTM6. Here we report that the expression of CMTM6 positively correlates with the epithelial to mesenchymal
Externí odkaz:
https://doaj.org/article/a6be9b9607674d048124b8683242ae16
Autor:
Laure Thibaudeau, Anna V. Taubenberger, Boris M. Holzapfel, Verena M. Quent, Tobias Fuehrmann, Parisa Hesami, Toby D. Brown, Paul D. Dalton, Carl A. Power, Brett G. Hollier, Dietmar W. Hutmacher
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 2, Pp 299-309 (2014)
The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism
Externí odkaz:
https://doaj.org/article/658332c5ae134b51b4a6cbcbfec323c3
Autor:
Brett G. Hollier, Zee Upton, Ola Söderberg, David I. Leavesley, Gaëlle Cane, Tristan I. Croll, Manaswini Sivaramakrishnan, Jacqui McGovern, Ali Shokoohmand, Gary K. Shooter, Abhishek S. Kashyap
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19848b031666ecc9752160a367907b61
https://doi.org/10.1158/1535-7163.22508251
https://doi.org/10.1158/1535-7163.22508251
Autor:
Ralph Buttyan, Xuesen Dong, Colin Collins, Colleen Nelson, Brett G. Hollier, Martin E. Gleave, Jane Foo, Mike Wang, Jackson Moore, Jessica M. Lovnicki, Varune R. Ramnarine, Ladan Fazli, Ahn R. Lee, Sarah Truong, Na Li, Amy A. Lubik, Josselin Caradec, Shabnam Massah, Mannan Nouri
Supplementary Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91483cc42bc1259500fcfea0ca391864
https://doi.org/10.1158/1078-0432.22474175.v1
https://doi.org/10.1158/1078-0432.22474175.v1
Autor:
Ralph Buttyan, Xuesen Dong, Colin Collins, Colleen Nelson, Brett G. Hollier, Martin E. Gleave, Jane Foo, Mike Wang, Jackson Moore, Jessica M. Lovnicki, Varune R. Ramnarine, Ladan Fazli, Ahn R. Lee, Sarah Truong, Na Li, Amy A. Lubik, Josselin Caradec, Shabnam Massah, Mannan Nouri
Supplementary Materials and Methods with detailed methods and primer and antibody lists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928f22d2ef882cdf78bfd0a5d30ec70b
https://doi.org/10.1158/1078-0432.22474172.v1
https://doi.org/10.1158/1078-0432.22474172.v1
Autor:
Ralph Buttyan, Xuesen Dong, Colin Collins, Colleen Nelson, Brett G. Hollier, Martin E. Gleave, Jane Foo, Mike Wang, Jackson Moore, Jessica M. Lovnicki, Varune R. Ramnarine, Ladan Fazli, Ahn R. Lee, Sarah Truong, Na Li, Amy A. Lubik, Josselin Caradec, Shabnam Massah, Mannan Nouri
Purpose:Patients with metastatic prostate cancer are increasingly presenting with treatment-resistant, androgen receptor–negative/low (AR−/Low) tumors, with or without neuroendocrine characteristics, in processes attributed to tumor cell plastici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c40e11637a9b46c78564fd37822fe19
https://doi.org/10.1158/1078-0432.c.6528710.v1
https://doi.org/10.1158/1078-0432.c.6528710.v1
Autor:
Ralph Buttyan, Xuesen Dong, Colin Collins, Colleen Nelson, Brett G. Hollier, Martin E. Gleave, Jane Foo, Mike Wang, Jackson Moore, Jessica M. Lovnicki, Varune R. Ramnarine, Ladan Fazli, Ahn R. Lee, Sarah Truong, Na Li, Amy A. Lubik, Josselin Caradec, Shabnam Massah, Mannan Nouri
Supplementary Figure Legends and Data Table containing developmental reprogramming 59-Gene commonly regulated gene list.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa762c4659455e12a33076b22e9c71d
https://doi.org/10.1158/1078-0432.22474181.v1
https://doi.org/10.1158/1078-0432.22474181.v1