Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brett D. Blakeley"'
Autor:
David W. Crawford, Brett D. Blakeley, Chringma Sherpa, Ite A. Laird-Offringa, Po-Han Chen, Stuart F.J. Le Grice, Brian R. McNaughton
Publikováno v:
ACS Chemical Biology. 11:2206-2215
Potent and selective recognition and modulation of disease-relevant RNAs remains a daunting challenge. We previously examined the utility of the U1A N-terminal RNA recognition motif as a scaffold for tailoring new RNA hairpin recognition, and showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a99a014f57fde355429101d7c8c2e1
https://doi.org/10.1021/acschembio.6b00145
https://doi.org/10.1021/acschembio.6b00145
Autor:
Utpal Mohan, Sandra M. DePorter, Ritwik Burai, Brian R. McNaughton, Blanton S. Tolbert, Brett D. Blakeley
Publikováno v:
Tetrahedron. 68:8837-8855
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1cbdff5f5128996a42005416368c1f
https://doi.org/10.1016/j.tet.2012.07.001
https://doi.org/10.1016/j.tet.2012.07.001
Autor:
Brett D. Blakeley, Brian R. McNaughton
Publikováno v:
ACS chemical biology. 9(6)
A multitude of RNA hairpins are directly implicated in human disease. Many of these RNAs are potentially valuable targets for drug discovery and basic research efforts. However, very little is known about the molecular requirements for achieving sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989fa2bb0f8b593b0fe1cf16867d952
https://pubmed.ncbi.nlm.nih.gov/24635165
https://pubmed.ncbi.nlm.nih.gov/24635165
Autor:
Melissa B. Coates, Brett D. Blakeley, Ite A. Laird-Offringa, Evelyn Tran, Jenifer E. Shattuck, Brian R. McNaughton
Publikováno v:
Biochemistry. 52(28)
U1A binds U1hpII, a hairpin RNA with a 10-nucleotide loop. A U1A mutant (ΔK50ΔM51) binds U1hpII-derived hairpins with shorter loops, making it an interesting scaffold for engineering or evolving proteins that bind similarly sized disease-related ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739d8335cd90f13f27ee76badcc457ad
https://pubmed.ncbi.nlm.nih.gov/23806102
https://pubmed.ncbi.nlm.nih.gov/23806102
Autor:
Utpal Mohan, Brian R. McNaughton, Blanton S. Tolbert, Ritwik Burai, Brett D. Blakeley, Sandra M. DePorter
Publikováno v:
ChemInform. 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af08880ef4c9f2468f404e3be901488b
https://doi.org/10.1002/chin.201310275
https://doi.org/10.1002/chin.201310275
Publikováno v:
Molecular BioSystems. 8:2036
Split-GFP reassembly is an operationally simple in vivo technique used to identify and study interactions involving proteins and/or peptides. However, the instability of split-GFP fragments and their susceptibility to aggregation place limitations on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5054f3d2ad330da739741489a38a9c
https://doi.org/10.1039/c2mb25130b
https://doi.org/10.1039/c2mb25130b