Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Brett D Hollingshead"'
Autor:
Mark P Labrecque, Mandeep K Takhar, Brett D Hollingshead, Gratien G Prefontaine, Gary H Perdew, Timothy V Beischlag
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29545 (2012)
The activated AHR/ARNT complex (AHRC) regulates the expression of target genes upon exposure to environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Importantly, evidence has shown that TCDD represses estrogen receptor (ER)
Externí odkaz:
https://doaj.org/article/15c17945b68e44948544a812e0705ebb
Autor:
Gary H. Perdew, Preeti Ramadoss, Brett C. DiNatale, Timothy V. Beischlag, Brett D. Hollingshead
The pleiotropic cytokine interleukin 6 (IL-6) is involved in immune cell homeostasis. Additionally, IL-6 expression and signaling in tumor cells have been shown to elicit both protumor and antitumor properties. There is a plethora of mechanistic know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612597ff456f8a455abf44923ebe5359
https://doi.org/10.1158/0008-5472.c.6497535
https://doi.org/10.1158/0008-5472.c.6497535
Autor:
Gary H. Perdew, Preeti Ramadoss, Brett C. DiNatale, Timothy V. Beischlag, Brett D. Hollingshead
Supplementary Figure 1 from Inflammatory Signaling and Aryl Hydrocarbon Receptor Mediate Synergistic Induction of Interleukin 6 in MCF-7 Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cea3f21b1080bfc587be6b607e71df6
https://doi.org/10.1158/0008-5472.22374657
https://doi.org/10.1158/0008-5472.22374657
Autor:
Allyn T. Londregan, Karlygash Aitmakhanova, James Bennett, Laura J. Byrnes, Daniel P. Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B. Coffey, João M. Dias, Matthew S. Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F. Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R. Harris, Brett D. Hollingshead, Kilian Huber, Magdalena Korczynska, Kimberly Lapham, Paula M. Loria, Arjun Narayanan, Dafydd R. Owen, Brigitt Raux, Parag V. Sahasrabudhe, Roger B. Ruggeri, Laura Díaz Sáez, Ingrid A. Stock, Benjamin A. Thuma, Andy Tsai, Alison E. Varghese
Publikováno v:
Journal of medicinal chemistry.
A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f200505c5effa14e470509072c0e10b
https://pubmed.ncbi.nlm.nih.gov/36562986
https://pubmed.ncbi.nlm.nih.gov/36562986
Autor:
Brett D. Hollingshead, Anna K. Kopec, Yutian Zhan, Timothy P. LaBranche, John W. Davis, Kyle Hayes, Srinivasa R. Mantena, Andrew W. Harrington, Laurence O. Whiteley, Zachary S. Stewart, Andrew D. Burdick
Publikováno v:
Toxicologic Pathology. 48:994-1007
Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345317f50829520d91ae5176802b72bd
https://doi.org/10.1177/0192623320968716
https://doi.org/10.1177/0192623320968716
Autor:
Martin E. Dowty, James F. Smith, Tsung H. Lin, Brian S. Gerstenberger, Matthew C. Griffor, Brett D. Hollingshead, Roger S. Gifford, Martin Hegen, Felix Vajdos, John D. Knafels, Andrew Fensome, Mary Ellen Banker, James D. Clark
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Translation of modulation of drug target activity to therapeutic effect is a critical aspect for all drug discovery programs. In this work we describe the profiling of a non-receptor tyrosine-protein kinase (TYK2) inhibitor which shows a functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2666dee375aa129903ab5f908c84a04a
http://link.springer.com/article/10.1038/s41598-020-65762-y
http://link.springer.com/article/10.1038/s41598-020-65762-y
Publikováno v:
The Journal of toxicological sciences. 47(1)
The nonclinical safety package to support development and approval of drugs intended to be administered by topical application generally follows International Council for Harmonisation multidisciplinary 3 (ICH M3) and topic specific safety (ICH S) gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa10481145f5fd10f9cba8591b4f2ae
https://pubmed.ncbi.nlm.nih.gov/34987136
https://pubmed.ncbi.nlm.nih.gov/34987136
Autor:
Zaher A. Radi, Gary Seitis, Yutian Zhan, Maria Engel, Stephanie L. Coffing, Katherine Hales, Maik Schuler, Lindsay Tomlinson, Saurabh G. Vispute, Jon C. Cook, Brett D. Hollingshead, Jennifer R. Cheung, Michael Homiski, Elizabeth Rubitski, Andrew Robertson
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 180(1)
Risk management of in vitro aneugens for topically applied compounds is not clearly defined because there is no validated methodology to accurately measure compound concentration in proliferating stratum basale keratinocytes of the skin. Here, we exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bedfa8cff11eb12e410362f2b71c2e
https://pubmed.ncbi.nlm.nih.gov/33481035
https://pubmed.ncbi.nlm.nih.gov/33481035
Autor:
Jim Finley, Lindsay Tomlinson, Sarah P. Nicholson, Stacey R. Oppenheimer, Jessica L. Moore, Maik Schuler, Nathan Heath Patterson, Kevin Beaumont, Brett D. Hollingshead, Zaher A. Radi, Colleen M. Doshna, Casey Ritenour, Richard M. Caprioli, Shawn P. O'Neil, Jon C. Cook, Jason Barricklow, Amanda King-Ahmad, Saurabh G. Vispute, Jeremy L. Norris
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 123
Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human risk assessment. For topical drugs, there is no standard method for measuring drug concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2406de3fb3f2281d80af4febb5bd971f
https://pubmed.ncbi.nlm.nih.gov/33872740
https://pubmed.ncbi.nlm.nih.gov/33872740
Autor:
Dafydd R. Owen, James D. Clark, Xiaojing Yang, Eddine Saiah, Martin Hegen, Brian S. Gerstenberger, Felix Vajdos, Catherine M. Ambler, Li Xing, Alpay Dermenci, Tsung H. Lin, Matthew Merrill Hayward, Raman Sharma, Xin Yang, David W. Lin, John D. Knafels, Eric P. Arnold, Mary-Ellen Banker, Stephen W. Wright, Martin E. Dowty, Brett D. Hollingshead, Andrew Fensome, Susan Fish, Matthew Frank Brown
Publikováno v:
Journal of medicinal chemistry. 63(22)
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, where it pairs with JAK2 or JAK1, respectively. On the basis of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62513b08e1117b54db6ce345e9512f36
https://pubmed.ncbi.nlm.nih.gov/32787094
https://pubmed.ncbi.nlm.nih.gov/32787094