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pro vyhledávání: '"Brett Collopy"'
Autor:
Michael Benjamino, Canghai Lu, Carlos Gonzalez, Brad Stasny, Jennifer Gangi, Brett Collopy, Melissa Hanson, Joseph Gleason, Woodrow Guinto, Monica Fung, Joseph Henley, Jeng-Dar Yang, Elisabeth Ille
Publikováno v:
Biotechnology and bioengineering. 98(1)
This case study focuses on the scale-up of a Sp2/0 mouse myeloma cell line based fed-batch bioreactor process, from the initial 3-L bench scale to the 2,500-L scale. A stepwise scale-up strategy that involved several intermediate steps in increasing