Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Brett C Sheppard"'
Autor:
Juan Pablo Hinestrosa, Rosalie C. Sears, Harmeet Dhani, Jean M. Lewis, Gregor Schroeder, Heath I. Balcer, Dove Keith, Brett C. Sheppard, Razelle Kurzrock, Paul R. Billings
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-9 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has an overall 5-year survival rate of just 12.5% and thus is among the leading causes of cancer deaths. When detected at early stages, PDAC survival rates improve substantially. Testing hig
Externí odkaz:
https://doaj.org/article/5e4d29b135ed4bf3b420bb53eeb82566
Autor:
Emerson Y. Chen, Adel Kardosh, Nima Nabavizadeh, Bryan Foster, Skye C. Mayo, Kevin G. Billingsley, Erin W. Gilbert, Christian Lanciault, Aaron Grossberg, Kenneth G. Bensch, Erin Maynard, Eric C. Anderson, Brett C. Sheppard, Charles R. Thomas Jr, Charles D. Lopez, Gina M. Vaccaro, OHSU Gastrointestinal Cancer Disease Group
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 12986-12995 (2023)
Abstract Background Neoadjuvant treatment with nab‐paclitaxel and gemcitabine for potentially operable pancreatic adenocarcinoma has not been well studied in a prospective interventional trial and could down‐stage tumors to achieve negative surgi
Externí odkaz:
https://doaj.org/article/7e8d9dc8460a49968f9cd834b3f15b44
Autor:
Vidhi M. Shah, Syed Rizvi, Alexander Smith, Motoyuki Tsuda, Madeline Krieger, Carl Pelz, Kevin MacPherson, Jenny Eng, Koei Chin, Michael W. Munks, Colin J. Daniel, Adel Al-Fatease, Galip Gürkan Yardimci, Ellen M. Langer, Jonathan R. Brody, Brett C. Sheppard, Adam WG. Alani, Rosalie C. Sears
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2651 (2023)
Pancreatic cancer remains a formidable challenge due to limited treatment options and its aggressive nature. In recent years, the naturally occurring anticancer compound juglone has emerged as a potential therapeutic candidate, showing promising resu
Externí odkaz:
https://doaj.org/article/e9a791e9964242ceae9c1bd09d990aef
Autor:
Matthew S. Dietz, Thomas L. Sutton, Brett S. Walker, Charles E. Gast, Luai Zarour, Sidharth K. Sengupta, John R. Swain, Jennifer Eng, Michael Parappilly, Kristen Limbach, Ariana Sattler, Erik Burlingame, Yuki Chin, Austin Gower, Jose L. Montoya Mira, Ajay Sapre, Yu-Jui Chiu, Daniel R. Clayburgh, SuEllen J. Pommier, Jeremy P. Cetnar, Jared M. Fischer, Jerry J. Jaboin, Rodney F. Pommier, Brett C. Sheppard, V. Liana Tsikitis, Alison H. Skalet, Skye C. Mayo, Charles D. Lopez, Joe W. Gray, Gordon B. Mills, Zahi Mitri, Young Hwan Chang, Koei Chin, Melissa H. Wong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contribute
Externí odkaz:
https://doaj.org/article/5b2e471d1c8144e4a081a30d60ac23cd
Autor:
Shay Behrens, Kristin Potter, Ranish K. Patel, Issac R. Schwantes, Thomas L. Sutton, Alicia J. Johnson, Rodney F. Pommier, Brett C. Sheppard
Publikováno v:
The American Journal of Surgery. 225:887-890
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e101680a2e52e9974501cce9f23949c8
https://doi.org/10.1016/j.amjsurg.2023.02.012
https://doi.org/10.1016/j.amjsurg.2023.02.012
Autor:
Ranish K. Patel, Thomas L. Sutton, Issac R. Schwantes, Shay Behrens, Rodney F. Pommier, Flavio G. Rocha, Brett C. Sheppard
Publikováno v:
Journal of Surgical Oncology. 127:956-965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4832ea8cd5bb0f66d335b04125d82e23
https://doi.org/10.1002/jso.27225
https://doi.org/10.1002/jso.27225
Autor:
Vidhi M. Shah, Craig Dorrell, Adel Al-Fatease, Brittany L. Allen-Petersen, Yeonhee Woo, Yuliya Bortnyak, Rohi Gheewala, Brett C. Sheppard, Rosalie C. Sears, Adam WG. Alani
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 713 (2022)
Pancreatic ductal adenocarcinoma (PDAC) presents as an unmet clinical challenge for drug delivery due to its unique hypoxic biology. Vinblastine-N-Oxide (CPD100) is a hypoxia-activated prodrug (HAP) that selectively converts to its parent compound, v
Externí odkaz:
https://doaj.org/article/683dea412c074d39add29de2c831bed1
Autor:
Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poo
Externí odkaz:
https://doaj.org/article/dc766b609bac46f8805ef957d3259818
Patency for autologous vein is superior to cadaveric vein in portal-mesenteric venous reconstruction
Autor:
Thomas L. Sutton, Victor Sandoval, David Warner, Gregory Moneta, Erin Gilbert, Skye C. Mayo, Amani D. Politano, Erin Maynard, Brett C. Sheppard, C. Kristian Enestvedt
Publikováno v:
HPB. 24:1326-1334
Portal venous reconstruction (PVR) is often needed during resection of hepatopancreato-biliary (HPB) malignancies. Primary repair (PR), autologous vein (AV), or cryopreserved cadaveric vein (CCV) are frequently utilized, however relative patency is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729fcf978bf2cb6c044e656b1a75882b
https://doi.org/10.1016/j.hpb.2022.01.004
https://doi.org/10.1016/j.hpb.2022.01.004
Autor:
Jack O'Grady, Thomas L. Sutton, Kristin C. Potter, Erin Gilbert, Rodney Pommier, Skye C. Mayo, Brett C. Sheppard
Publikováno v:
The American Journal of Surgery. 224:737-741
Postoperative pancreatic fistula (POPF) is a feared complication in pancreatic resection. Gravity drainage (GD) is hypothesized to reduce POPF versus closed-suction drainage (CSD). We sought to evaluate this theory.Six-hundred-twenty-nine patients un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e6a556fc1acacb05a2ec42ecf4e7e1
https://doi.org/10.1016/j.amjsurg.2022.02.063
https://doi.org/10.1016/j.amjsurg.2022.02.063