Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brett A. Simms"'
Autor:
Jeffrey R. Buchhalter, Morris H. Scantlebury, Sabrina D’Alfonso, Juan Pablo Appendino, Luis Bello Espinosa, Brian L. Brooks, Curtis Claassen, Jane Corbeil, David Czank, Stafford Dean, Alice W. Ho, Julia Jacobs, Maarit Mackay, Joka McMahon, Aleksandra Mineyko, Jong M. Rho, Trina Roberts, Sonia Rothenmund, Gary Ruta, Tyson Sawchuk, Brett A. Simms, Kim Smyth, Tammy Still, Nancy Thornton
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 345-358 (2021)
Abstract Objective To describe the development of the Pediatric Epilepsy Outcome‐Informatics Project (PEOIP) at Alberta Children's Hospital (ACH), which was created to provide standardized, point‐of‐care data entry; near‐time data analysis; a
Externí odkaz:
https://doaj.org/article/d6fbdae1b37f4ed4ba403f1f5aa126d1
Autor:
Hadhimulya Asmara, Ileana Micu, Arsalan P. Rizwan, Giriraj Sahu, Brett A. Simms, Fang-Xiong Zhang, Jordan D. T. Engbers, Peter K. Stys, Gerald W. Zamponi, Ray W. Turner
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-15 (2017)
Abstract Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of the Cav3 family have th
Externí odkaz:
https://doaj.org/article/6b30ca7a1d8445b281ceed3254df4263
Autor:
David Czank, Aleksandra Mineyko, Luis Bello Espinosa, Alice W. Ho, Stafford Dean, Curtis S Claassen, Julia Jacobs, Morris H. Scantlebury, Brett A. Simms, Joka McMahon, Jeffrey Buchhalter, Maarit Mackay, Gary Ruta, Juan Pablo Appendino, Sabrina D'Alfonso, Brian L. Brooks, Kim Smyth, Tammy Still, Trina Roberts, Sonia Rothenmund, Jong M. Rho, Nancy Thornton, Jane Corbeil, Tyson Sawchuk
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 345-358 (2021)
Epilepsia Open
Epilepsia Open
Author(s): Buchhalter, Jeffrey R; Scantlebury, Morris H; D'Alfonso, Sabrina; Pablo Appendino, Juan; Bello Espinosa, Luis; Brooks, Brian L; Claassen, Curtis; Corbeil, Jane; Czank, David; Dean, Stafford; Ho, Alice W; Jacobs, Julia; Mackay, Maarit; McMa
Publikováno v:
Paediatrics Publications
Canadian Journal of Surgery
Canadian Journal of Surgery
In 2017, a provincial guideline was created to fast track and standardize care for pediatric appendicitis in Alberta. We conducted a study to determine the impact of implementation of the guideline at our institution on length of stay (LOS), antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fabe082fb90279d8375ff7a6f7f4681
https://ir.lib.uwo.ca/paedpub/2041
https://ir.lib.uwo.ca/paedpub/2041
Autor:
Gerald W. Zamponi, Brett A. Simms
Publikováno v:
Neuron. 82:24-45
Voltage-gated calcium channels are the primary mediators of depolarization-induced calcium entry into neurons. There is great diversity of calcium channel subtypes due to multiple genes that encode calcium channel α1 subunits, coassembly with a vari
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 466:1793-1803
The L-type voltage-gated calcium channel Cav1.2 is important for excitation-contraction coupling in the heart, as well as CREB-mediated transcription in the brain. The ubiquitous calcium-binding protein calmodulin (CaM) is known to modulate calcium-d
Autor:
H. William Tedford, Lina Chen, Brett A. Simms, Haitao You, Jan Walcher, Tamara Hermosilla, Christophe Altier, Agustin Garcia-Caballero, Gerald W. Zamponi
Publikováno v:
Nature Neuroscience. 14:173-180
It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found that the Cavβ subunit increased membrane expression of C
Publikováno v:
Biophysical Journal. 89(5):3042-3048
When transiently expressed in tsA-201 cells, Ca(v)1.4 calcium channels support only modest whole-cell currents with unusually slow voltage-dependent inactivation kinetics. To examine the basis for this unique behavior we used cell-attached patch sing
Publikováno v:
Channels (Austin, Tex.). 8(4)
Voltage-gated calcium channels (VGCCs), calmodulin (CaM), and calmodulin kinase II (CaMKII) are essential for various nervous system functions. CaM and CaMKII differentially regulate calcium depend...
Publikováno v:
Pflugers Archiv : European journal of physiology. 467(4)
The L-type voltage-gated calcium channel Cav1.2 and the calcium-activated CaM kinase cascade both regulate excitation transcription coupling in the brain. CaM kinase is known to associate with the C terminus of Cav1.2 in a region called the PreIQ-IQ