Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Brett A. McKinney"'
Autor:
Kaiping Burrows, Leandra K. Figueroa-Hall, Jennifer L. Stewart, Ahlam M. Alarbi, Rayus Kuplicki, Bethany N. Hannafon, Chibing Tan, Victoria B. Risbrough, Brett A. McKinney, Rajagopal Ramesh, Teresa A. Victor, Robin Aupperle, Jonathan Savitz, T. Kent Teague, Sahib S. Khalsa, Martin P. Paulus
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain neuronal-enriched extracellular vesicle (NEEV
Externí odkaz:
https://doaj.org/article/bd91e122d3dd4823b57dc7ef6d18d79a
Publikováno v:
Mathematics, Vol 11, Iss 22, p 4600 (2023)
Historically, humans have been infected by mosquito-borne diseases, including dengue fever and malaria fever. There is an urgent need for comprehensive methods in the prevention, control, and awareness of the hazards posed by dengue and malaria fever
Externí odkaz:
https://doaj.org/article/8ba85c6bd6dd4fe58b2ffac1c668e94b
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100534- (2022)
The identification of gene expression-based biomarkers for major depressive disorder (MDD) continues to be an important challenge. In order to identify candidate biomarkers and mechanisms, we apply statistical and machine learning feature selection t
Externí odkaz:
https://doaj.org/article/ee93310db8ec4ef594ce116a6d71a212
Autor:
Rayus Kuplicki, James Touthang, Obada Al Zoubi, Ahmad Mayeli, Masaya Misaki, NeuroMAP-Investigators, Robin L. Aupperle, T. Kent Teague, Brett A. McKinney, Martin P. Paulus, Jerzy Bodurka
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Neuroscience studies require considerable bioinformatic support and expertise. Numerous high-dimensional and multimodal datasets must be preprocessed and integrated to create robust and reproducible analysis pipelines. We describe a common data eleme
Externí odkaz:
https://doaj.org/article/d56ceddb40ea4a2bbe1738851da31b2d
Autor:
Abdulmohammad Pezeshki, Inna G. Ovsyannikova, Brett A. McKinney, Gregory A. Poland, Richard B. Kennedy
Publikováno v:
Expert Review of Vaccines, Vol 18, Iss 3, Pp 253-267 (2019)
Introduction: Emerging infectious diseases are a major threat to public health, and while vaccines have proven to be one of the most effective preventive measures for infectious diseases, we still do not have safe and effective vaccines against many
Externí odkaz:
https://doaj.org/article/09f4b564a1e84dbaa7e69743e680eaed
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Nearest-neighbor Projected-Distance Regression (NPDR) is a feature selection technique that uses nearest-neighbors in high dimensional data to detect complex multivariate effects including epistasis. NPDR uses a regression formalism that allows stati
Externí odkaz:
https://doaj.org/article/f7a495ae0e4e42989f6402d641e90ed3
Autor:
Trang T. Le, Rayus T. Kuplicki, Brett A. McKinney, Hung-Wen Yeh, Wesley K. Thompson, Martin P. Paulus, Tulsa 1000 Investigators, Robin L Aupperle, Jerzy Bodurka, Yoon-Hee Cha, Justin S. Feinstein, Sahib S. Khalsa, Jonathan Savitz, W Kyle Simmons, Teresa A Victor
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Several imaging modalities, including T1-weighted structural imaging, diffusion tensor imaging, and functional MRI can show chronological age related changes. Employing machine learning algorithms, an individual's imaging data can predict their age w
Externí odkaz:
https://doaj.org/article/4232dcc25b064340a486e24431256dac
Autor:
Sean M. Santos, Mert Icyuz, Ilya Pound, Doreen William, Jingyu Guo, Brett A. McKinney, Michael Niederweis, John Rodgers, John L. Hartman
Publikováno v:
Genes, Vol 10, Iss 10, p 770 (2019)
Knowledge about synthetic lethality can be applied to enhance the efficacy of anticancer therapies in individual patients harboring genetic alterations in their cancer that specifically render it vulnerable. We investigated the potential for high-res
Externí odkaz:
https://doaj.org/article/8c67f3d524a94122a151ad24115b5dde
Publikováno v:
Microorganisms, Vol 7, Iss 3, p 79 (2019)
Vaccination is an effective prevention of influenza infection. However, certain individuals develop a lower antibody response after vaccination, which may lead to susceptibility to subsequent infection. An important challenge in human health is to fi
Externí odkaz:
https://doaj.org/article/7a7015d6d1ff49b99bab7f4da1e3b107
Publikováno v:
Cancer Informatics, Vol 6, Pp 137-145 (2008)
Chromatin immunoprecipitation (ChIP) analysis is widely used to identify the locations in genomes occupied by transcription factors (TFs). The approach involves chemical cross-linking of DNA with associated proteins, fragmentation of chromatin by son
Externí odkaz:
https://doaj.org/article/659e9101fa534f12a9d6a9d9b3bfc1aa