Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Brett A. McGregor"'
Autor:
Brett A. McGregor, Elham Razmjou, Hossein Hooshyar, Drew R. Seeger, Svetlana A. Golovko, Mikhail Y. Golovko, Steven M. Singer, Junguk Hur, Shahram Solaymani-Mohammadi
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Background The mechanisms underlying the clinical outcome disparity during human infection with Giardia duodenalis are still unclear. In recent years, evidence has pointed to the roles of host factors as well as parasite’s genetic heteroge
Externí odkaz:
https://doaj.org/article/95b79fddc8524a69b6e268fa44451f35
Autor:
Sarah E. Elzinga, Stephanie A. Eid, Brett A. McGregor, Dae-Gyu Jang, Lucy M. Hinder, Jacqueline R. Dauch, John M. Hayes, Hongyu Zhang, Kai Guo, Subramaniam Pennathur, Matthias Kretzler, Frank C. Brosius, Emily J. Koubek, Eva L. Feldman, Junguk Hur
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/d240158514aa40fe8b66d99c549dc073
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
A major challenge in drug development is safety and toxicity concerns due to drug side effects. One such side effect, drug-induced liver injury (DILI), is considered a primary factor in regulatory clearance. The Critical Assessment of Massive Data An
Externí odkaz:
https://doaj.org/article/737aedabf25f4bdf8b000c30ede26c17
Autor:
Md. Obayed Raihan, Brenna M. Espelien, Brett A. McGregor, Courtney Hanson, Afrina Brishti, Nathan A. Velaris, Travis D. Alvine, David S. Bradley, Matthew Nilles, Mikhail Y. Golovko, Junguk Hur, James E. Porter
Publikováno v:
Vaccines, Vol 10, Iss 2, p 321 (2022)
BscF is a type III secretion system (T3SS) needle protein from Bordetella pertussis and has previously been shown to induce a sufficient Th1 and Th17 response in human monocytes and mice as a prerequisite for long-lasting protective immunity against
Externí odkaz:
https://doaj.org/article/a374c2bf549245daaf6f8e3113d3bf48
Autor:
Md. Obayed Raihan, Brett A. McGregor, Nathan A. Velaris, Afrina Brishti, Junguk Hur, James E. Porter
Publikováno v:
Methods and Protocols, Vol 4, Iss 4, p 86 (2021)
Microglia, the resident brain immune effectors cells, show dynamic activation level changes for most neuropsychiatric diseases, reflecting their complex regulatory function and potential as a therapeutic target. Emerging single-cell molecular biology
Externí odkaz:
https://doaj.org/article/ac9302ee72764ed99f02ed2a9d5b14ad
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The quintessential biological response to disease is inflammation. It is a driver and an important element in a wide range of pathological states. Pharmacological management of inflammation is therefore central in the clinical setting. Anti-inflammat
Externí odkaz:
https://doaj.org/article/661c5bb9350d4e228934e78d3b5283af
Autor:
Obayed Raihan, Brett A. McGregor, James E. Porter, Othman Ghribi, Jared Schommer, Kai Guo, Junguk Hur
Publikováno v:
Neuroscience. 468:186-198
Synucleinopathy disorders are characterized by aggregates of α-synuclein (α-syn), which engage microglia to elicit a neuroinflammatory response. Here, we determined the gene expression and DNA methylation changes in microglia induced by aggregate
Autor:
Md.Obayed Raihan, Brenna M. Espelien, Courtney Hanson, Brett A. McGregor, Nathan A. Velaris, Travis D. Alvine, Svetlana Al. Golovko, David S. Bradley, Matthew Nilles, Mikhail Y. Glovko, Junguk Hur, James E. Porter
Publikováno v:
Prostaglandins Leukot Essent Fatty Acids
Prostanoids are potent inflammatory mediators that play a regulatory role in the innate immune activation of the adaptive immune response to determine the duration of protection against infection. We aim to quantify the modulation of prostanoids prof
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Drug-induced peripheral neuropathy is a side effect of a variety of therapeutic agents that can affect therapeutic adherence and lead to regimen modifications, impacting patient quality of life. The molecular mechanisms involved in the development of
Autor:
Brett A. McGregor, Jared Schommer, Kai Guo, Md. Obayed Raihan, Othman Ghribi, Junguk Hur, James E. Porter
Publikováno v:
Neuroscience. 492:108