Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Brett A. Kaufman"'
Autor:
Sarah A. Ware, Corrine R. Kliment, Luca Giordano, Kevin M. Redding, William L. Rumsey, Stewart Bates, Yingze Zhang, Frank C. Sciurba, S. Mehdi Nouraie, Brett A. Kaufman
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract The question addressed by the study Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and rel
Externí odkaz:
https://doaj.org/article/ad97e0d7548243e9b1bfbdb12525f3ef
Autor:
Gabriel Sturm, Kalpita R. Karan, Anna S. Monzel, Balaji Santhanam, Tanja Taivassalo, Céline Bris, Sarah A. Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J. McManus, Andres Cardenas, Jue Lin, Elissa S. Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G. Haller, Guy Lenaers, Douglas C. Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A. Kaufman, Erin L. Seifert, Michio Hirano, Martin Picard
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-22 (2023)
A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a ce
Externí odkaz:
https://doaj.org/article/8f3a6949c7834f1f9cf472f8feac04b2
Autor:
Gabriel Sturm, Anna S. Monzel, Kalpita R. Karan, Jeremy Michelson, Sarah A. Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P. Murphy, Morgan E. Levine, Steve Horvath, Daniel W. Belsky, Shuang Wang, Vincent Procaccio, Brett A. Kaufman, Michio Hirano, Martin Picard
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-19 (2022)
Measurement(s) gene expression assay • DNA Methylation • Telomere Length • Seahorse Bioenergetics • mtDNA copy number • Whole Genome Sequencing • Cytokine • cell-free DNA • mtDNA sequencing • cell-free GDF15 • cell-free IL6 Techno
Externí odkaz:
https://doaj.org/article/d6a7639344dc491583d7e15621e35c15
Autor:
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract 8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination a
Externí odkaz:
https://doaj.org/article/6865606e68fe4a83a2797cb46fc67eee
Autor:
Cody A. Rutledge, Claudia Lagranha, Takuto Chiba, Kevin Redding, Donna B. Stolz, Eric Goetzman, Sunder Sims-Lucas, Brett A. Kaufman
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 4, Iss , Pp 100034- (2023)
Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had less eviden
Externí odkaz:
https://doaj.org/article/e1a713b4f1ec4938b59f75d481a7de4c
Autor:
Manling Zhang, Ning Feng, Zishan Peng, Dharendra Thapa, Michael W. Stoner, Janet R. Manning, Charles F. McTiernan, Xue Yang, Michael J. Jurczak, Danielle Guimaraes, Krithika Rao, Sruti Shiva, Brett A. Kaufman, Michael N. Sack, Iain Scott
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106942- (2023)
Summary: General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation status and activity o
Externí odkaz:
https://doaj.org/article/8909375df39c4b46833adac7bdc0ad27
Autor:
Siddharth Nath, Nicholas S. Caron, Linda May, Oxana B. Gluscencova, Jill Kolesar, Lauren Brady, Brett A. Kaufman, Gabrielle L. Boulianne, Amadeo R. Rodriguez, Mark A. Tarnopolsky, Ray Truant
Publikováno v:
Human Genome Variation, Vol 9, Iss 1, Pp 1-12 (2022)
Neurodegenerative disease: Finding new mutations associated with ataxia Two genetic mutations combine to cause a novel variant of spinocerebellar ataxia (SCA), a rare neurodegenerative disease. SCA affects the cerebellum, a brain region that controls
Externí odkaz:
https://doaj.org/article/3daafa26d2c04bf0a4a4c5ae75472e88
Autor:
Vaibhav Sidarala, Jie Zhu, Elena Levi-D’Ancona, Gemma L. Pearson, Emma C. Reck, Emily M. Walker, Brett A. Kaufman, Scott A. Soleimanpour
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Externí odkaz:
https://doaj.org/article/247caaeb45e74492958ffd5942fda4db
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Autor:
Cody Rutledge, George Cater, Brenda McMahon, Lanping Guo, Seyed Mehdi Nouraie, Yijen Wu, Flordeliza Villanueva, Brett A. Kaufman
Publikováno v:
Cardiovascular Ultrasound, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background Traditional preclinical echocardiography (ECHO) modalities, including 1-dimensional motion-mode (M-Mode) and 2-dimensional long axis (2D-US), rely on geometric and temporal assumptions about the heart for volumetric measurements.
Externí odkaz:
https://doaj.org/article/cc69e57d2cc44edfbd159177c01f829c