Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Brett A. Graham"'
Autor:
Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher, Laura M. Stanton, Nicholas J. Burton, Amy J. Pearl, Gavan P. McNally, Jaideep S. Bains, Tamás Füzesi, Brett A. Graham, Elizabeth E. Manning, Christopher V. Dayas
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motiva
Externí odkaz:
https://doaj.org/article/e892cfa1b0cc4b1c91328ec5064f90fa
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Mark A. Gradwell, Kelly M. Smith, Christopher V. Dayas, Douglas W. Smith, David I. Hughes, Robert J. Callister, Brett A. Graham
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
The incidence of pain symptoms such as allodynia are known to increase with age. Parvalbumin expressing interneurons (PVINs) within the dorsal horn (DH) of the spinal cord play an important role in allodynia whereby their inhibitory connections preve
Externí odkaz:
https://doaj.org/article/baec76e0ce484c0f82624bcd0055f3e3
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of highly specialized neurons called projection neurons
Externí odkaz:
https://doaj.org/article/5f0fa275e7564d96b0f9b7499d0fea4f
Autor:
Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Tyler J. Browne, Robert J. Callister, Douglas W. Smith, Phillip Jobling, David I. Hughes, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures. To date, diffi
Externí odkaz:
https://doaj.org/article/bede2859bc2b436ba560bb1b689f3474
Autor:
Tyler J. Browne, Mark A. Gradwell, Jacqueline A. Iredale, Jessica F. Maden, Robert J. Callister, David I. Hughes, Christopher V. Dayas, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The superficial dorsal horn (SDH, LI-II) of the spinal cord receives and processes multimodal sensory information from skin, muscle, joints, and viscera then relay it to the brain. Neurons within the SDH fall into two broad categories, projection neu
Externí odkaz:
https://doaj.org/article/f7cbb58569d74ea7bf1a6fa6f2d258b2
Autor:
Kieran A. Boyle, Mark A. Gradwell, Toshiharu Yasaka, Allen C. Dickie, Erika Polgár, Robert P. Ganley, Desmond P.H. Orr, Masahiko Watanabe, Victoria E. Abraira, Emily D. Kuehn, Amanda L. Zimmerman, David D. Ginty, Robert J. Callister, Brett A. Graham, David I. Hughes
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 526-540.e6 (2019)
Summary: Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal circuits underlying sensory perception. Here, we show that parvalbumin (PV)-expressin
Externí odkaz:
https://doaj.org/article/68a04d8abb6447fcbfe560005ba70925
Autor:
Han-Shen Tae, Kelly M. Smith, A. Marie Phillips, Kieran A. Boyle, Melody Li, Ian C. Forster, Robert J. Hatch, Robert Richardson, David I. Hughes, Brett A. Graham, Steven Petrou, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated Ih in brain slice experiments. However, evidence showing that GBP directly modulat
Externí odkaz:
https://doaj.org/article/3f9fcd99967a47b0be0f24a378bc8dff
Autor:
Elisabeth Bosch, Bernt Popp, Esther Güse, Cindy Skinner, Pleuntje J. van der Sluijs, Isabelle Maystadt, Anna Maria Pinto, Alessandra Renieri, Lucia Pia Bruno, Stefania Granata, Carlo Marcelis, Özlem Baysal, Dewi Hartwich, Laura Holthöfer, Bertrand Isidor, Benjamin Cogne, Dagmar Wieczorek, Valeria Capra, Marcello Scala, Patrizia De Marco, Marzia Ognibene, Rami Abou Jamra, Konrad Platzer, Lauren B. Carter, Outi Kuismin, Arie van Haeringen, Reza Maroofian, Irene Valenzuela, Ivon Cuscò, Julian A. Martinez-Agosto, Ahna M. Rabani, Heather C. Mefford, Elaine M. Pereira, Charlotte Close, Kwame Anyane-Yeboa, Mallory Wagner, Mark C. Hannibal, Pia Zacher, Isabelle Thiffault, Gea Beunders, Muhammad Umair, Priya T. Bhola, Erin McGinnis, John Millichap, Jiddeke M van de Kamp, Eloise J. Prijoles, Amy Dobson, Amelle Shillington, Brett H. Graham, Evan-Jacob Garcia, Maureen Kelly Galindo, Fabienne G. Ropers, Esther AR Nibbeling, Gail Hubbard, Catherine Karimov, Guido Goj, Renee Bend, Julie Rath, Michelle M Morrow, Francisca Millan, Vincenzo Salpietro, Annalaura Torella, Vincenzo Nigro, Mitja Kurki, Roger E Stevenson, Gijs W.E. Santen, Markus Zweier, Philippe M. Campeau, Mariasavina Severino, André Reis, Andrea Accogli, Georgia Vasileiou
PURPOSECoffin-Siris and Nicolaides-Baraitser syndromes, are recognisable neurodevelopmental disorders caused by germline variants in BAF complex subunits. TheSMARCC2BAFopathy was recently reported. Herein, we present clinical and molecular data on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27085d1605a13771b0976056173917e
https://doi.org/10.1101/2023.03.30.23287962
https://doi.org/10.1101/2023.03.30.23287962
Autor:
Caitlin S Mitchell, Erin J Campbell, Simon D Fisher, Laura M Stanton, Nicholas J Burton, Amy J Pearl, Gavan P McNally, Jaideep S Bains, Tamás Füzesi, Brett A Graham, Elizabeth E Manning, Christopher V Dayas
Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa505cf524c72ba00e5a74a80158b576
https://doi.org/10.1101/2023.02.03.527084
https://doi.org/10.1101/2023.02.03.527084