Zobrazeno 1 - 10
of 536
pro vyhledávání: '"Brett A. Graham"'
Autor:
Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher, Laura M. Stanton, Nicholas J. Burton, Amy J. Pearl, Gavan P. McNally, Jaideep S. Bains, Tamás Füzesi, Brett A. Graham, Elizabeth E. Manning, Christopher V. Dayas
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motiva
Externí odkaz:
https://doaj.org/article/e892cfa1b0cc4b1c91328ec5064f90fa
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Makayla S. Lancaster, Byungwook Kim, Emma H. Doud, Mason D. Tate, Ahmad D. Sharify, Hongyu Gao, Duojiao Chen, Ed Simpson, Patrick Gillespie, Xiaona Chu, Marcus J. Miller, Yue Wang, Yunlong Liu, Amber L. Mosley, Jungsu Kim, Brett H. Graham
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113241- (2023)
Summary: Lysine succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the tricarboxylic acid cycle. Deficiency of succinyl-CoA synthetase (SCS), the tricarboxylic acid cycle enzyme catalyzing the inte
Externí odkaz:
https://doaj.org/article/3667fe089082442185bcfa19a5753f0c
Autor:
Makayla S. Lancaster, Brett H. Graham
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10725 (2023)
Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans. SCS catalyzes the interconversion of succinyl-CoA to succinate, couple
Externí odkaz:
https://doaj.org/article/51ab90f8e61f40c9833660f5b1e0c287
Autor:
Mark A. Gradwell, Kelly M. Smith, Christopher V. Dayas, Douglas W. Smith, David I. Hughes, Robert J. Callister, Brett A. Graham
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
The incidence of pain symptoms such as allodynia are known to increase with age. Parvalbumin expressing interneurons (PVINs) within the dorsal horn (DH) of the spinal cord play an important role in allodynia whereby their inhibitory connections preve
Externí odkaz:
https://doaj.org/article/baec76e0ce484c0f82624bcd0055f3e3
Autor:
Wenjing Yin, Derrick Brittain, Jay Borseth, Marie E. Scott, Derric Williams, Jedediah Perkins, Christopher S. Own, Matthew Murfitt, Russel M. Torres, Daniel Kapner, Gayathri Mahalingam, Adam Bleckert, Daniel Castelli, David Reid, Wei-Chung Allen Lee, Brett J. Graham, Marc Takeno, Daniel J. Bumbarger, Colin Farrell, R. Clay Reid, Nuno Macarico da Costa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Electron microscopy (EM) is the gold standard for biological ultrastructure but acquisition speed is slow, making it unsuitable for large volumes. Here the authors present a parallel imaging pipeline for continuous autonomous imaging with six transmi
Externí odkaz:
https://doaj.org/article/1636c301c307427c8f6136be5b12c53a
Autor:
Michael E Kelly, Lissa Peeling, Jessica Hamilton, Laura Schwartz, Jessalyn K Holodinsky, Vivian N Onaemo, Ruth Whelan, Gary Hunter, Brett R Graham, Lori Latta
Publikováno v:
BMJ Open Quality, Vol 10, Iss 3 (2021)
Background For ischaemic stroke, outcome severity is heavily time dependent. Systems of care need to be in place to ensure that patients with stroke are treated quickly and appropriately across entire health regions. Prior to this study, the province
Externí odkaz:
https://doaj.org/article/04695d2ae78b4083aac2bb4262c9c19d
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2021)
High-throughput behavioral phenotyping is critical to genetic or chemical screening approaches. Zebrafish larvae are amenable to high-throughput behavioral screening because of their rapid development, small size, and conserved vertebrate brain archi
Externí odkaz:
https://doaj.org/article/f88ff121b78545a0a1f8638b1643e2b2
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of highly specialized neurons called projection neurons
Externí odkaz:
https://doaj.org/article/5f0fa275e7564d96b0f9b7499d0fea4f
Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver–Brain Axis for Lipid Homeostasis
Autor:
Sofia Milosavljevic, Kevin E. Glinton, Xiqi Li, Cláudia Medeiros, Patrick Gillespie, John R. Seavitt, Brett H. Graham, Sarah H. Elsea
Publikováno v:
Metabolites, Vol 12, Iss 4, p 351 (2022)
Though biallelic variants in SLC13A5 are known to cause severe encephalopathy, the mechanism of this disease is poorly understood. SLC13A5 protein deficiency reduces citrate transport into the cell. Downstream abnormalities in fatty acid synthesis an
Externí odkaz:
https://doaj.org/article/e32e6342040b41ca94d5665fb28d87e4