Výsledky vyhledávání - "Brett A. Carlson"

Akademický článek

ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma

Autor: Daniel J. Laverty, Shiv K. Gupta, Gary A. Bradshaw, Alexander S. Hunter, Brett L. Carlson, Nery Matias Calmo, Jiajia Chen, Shulan Tian, Jann N. Sarkaria, Zachary D. Nagel

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a method for simultaneously measuring non-homologous end joining (NHEJ), homologous recombi

Externí odkaz: https://doaj.org/article/7479bc151d014f1284e20c0dda5db9c3

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Akademický článek

Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial

Autor: Melissa Adkins-Hempel, Sandra J. Japuntich, Michelle Chrastek, Shira Dunsiger, Christopher E. Breault, Woubeshet Ayenew, Susan A. Everson-Rose, Prabhjot S. Nijjar, Beth C. Bock, Wen-Chih Wu, Michael D. Miedema, Brett M. Carlson, Andrew M. Busch

Publikováno v: Addiction Science & Clinical Practice, Vol 18, Iss 1, Pp 1-16 (2023)

Abstract Background Approximately 400,000 people who smoke cigarettes survive Acute Coronary Syndrome (ACS; unstable angina, ST and non-ST elevation myocardial infarction) each year in the US. Continued smoking following ACS is an independent predict

Externí odkaz: https://doaj.org/article/9e3c7f9c51de4221a7baabfaf6f7d1ca

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Akademický článek

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Autor: Kshama Gupta, Ivan Vuckovic, Song Zhang, Yuning Xiong, Brett L. Carlson, Joshua Jacobs, Ian Olson, Xuan-Mai Petterson, Slobodan I. Macura, Jann Sarkaria, Terry C. Burns

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Glioblastoma (GBM) is uniformly fatal with a 1-year median survival, despite best available treatment, including radiotherapy (RT). Impacts of prior RT on tumor recurrence are poorly understood but may increase tumor aggressiveness. Metabolic changes

Externí odkaz: https://doaj.org/article/7930d328fe63410ca2add16c7b58b4d7

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Akademický článek

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib,

Externí odkaz: https://doaj.org/article/17219987055045cbbd74e20d4356a523

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WSD-0922, a novel brain-penetrant inhibitor of EGFR, promotes survival in glioblastoma mouse models

Publikováno v: Neuro-Oncology Advances.

Background Although the epidermal growth factor receptor (EGFR) is a frequent oncogenic driver in glioblastoma (GBM), efforts to therapeutically target this protein have been largely unsuccessful. The present pre-clinical study evaluated the novel EG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2ce3a1d223fff1c6b6c405e08aedd04
https://doi.org/10.1093/noajnl/vdad066

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