Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Brett A. Boghigian"'
Publikováno v:
Letters in Applied Microbiology. 54:140-148
Aims: This paper utilized quantitative LC-MS/MS to profile the short-chain acyl-CoA levels of several strains of Escherichia coli engineered for heterologous polyketide production. To further compare and potentially expand the levels of available acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbe75be903e7125f2643487e79e75e19
https://doi.org/10.1111/j.1472-765x.2011.03184.x
https://doi.org/10.1111/j.1472-765x.2011.03184.x
Publikováno v:
Appl Microbiol Biotechnol
Taxadiene is the first dedicated intermediate in the biosynthetic pathway of the anticancer compound Taxol. Recent studies have taken advantage of heterologous hosts to produce taxadiene and other isoprenoid compounds, and such ventures now offer res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935fa5546126a76f839bf77a420fabe2
https://doi.org/10.1007/s00253-011-3725-1
https://doi.org/10.1007/s00253-011-3725-1
Publikováno v:
J Ind Microbiol Biotechnol
Natural products have long served as rich sources of drugs possessing a wide range of pharmacological activities. The discovery and development of natural product drug candidates is often hampered by the inability to efficiently scale and produce a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb24301dbcf52a4731b1dd18e47435b
https://doi.org/10.1007/s10295-011-0969-9
https://doi.org/10.1007/s10295-011-0969-9
Publikováno v:
Journal of Theoretical Biology. 262:197-207
Polyketides represent a class of natural product small molecules with an impressive range of medicinal activities. In order to improve access to therapeutic polyketide compounds, heterologous metabolic engineering has been applied to transfer polyket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6915c5a8c8a2bf1aa700e18e2bba842b
https://doi.org/10.1016/j.jtbi.2009.10.006
https://doi.org/10.1016/j.jtbi.2009.10.006
Publikováno v:
Microbial Biotechnology. 2:390-394
Heterologous biosynthesis offers a new way to capture the medicinal properties presented by complex natural products. In this study, production of 6-deoxyerythronolide B (6dEB), the polyketide precursor to the antibiotic erythromycin, was used to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::299b7f4de711b93a4be74c46b44e13d9
https://doi.org/10.1111/j.1751-7915.2009.00099.x
https://doi.org/10.1111/j.1751-7915.2009.00099.x
Autor:
Patrick Courtney, Brett A. Boghigian, Elaine Scrivener, Mary F. Lopez, Alla Bogdanova, Eva Golenko, Eric Denoyer, Wayne F. Patton, Peter Jackson, Alvydas Mikulskis
Publikováno v:
PROTEOMICS. 5:4354-4366
Advances in gel-based nonradioactive protein expression and PTM detection using fluorophores has served as the impetus for developing analytical instrumentation with improved imaging capabilities. We describe a CCD camera-based imaging instrument, eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4be41b3733fa05294eac71902874a0
https://doi.org/10.1002/pmic.200500062
https://doi.org/10.1002/pmic.200500062
Publikováno v:
Planta Medica. 78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de0a94761c32f3bcb114889d188c424
https://doi.org/10.1055/s-0032-1320300
https://doi.org/10.1055/s-0032-1320300
Autor:
Parayil Kumaran Ajikumar, Gregory Stephanopoulos, Brett A. Boghigian, Daniel F. Salas, Blaine A. Pfeifer
Publikováno v:
Appl Microbiol Biotechnol
Taxa-4(5),11(12)-diene is the first dedicated intermediate in the metabolic pathway responsible for synthesizing the anticancer compound Taxol. In this study, the heterologous production of taxadiene was established in and analyzed between K- and B-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b27be74467f7c1b68e29e7a34e25d71
https://europepmc.org/articles/PMC9896015/
https://europepmc.org/articles/PMC9896015/
ChemInform Abstract: Methods and Options for the Heterologous Production of Complex Natural Products
Publikováno v:
ChemInform. 42
This review will detail the motivations, experimental approaches, and growing list of successful cases associated with the heterologous production of complex natural products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2f3002dcb022ad07d627acd2073289f
https://doi.org/10.1002/chin.201114276
https://doi.org/10.1002/chin.201114276
Publikováno v:
Nat Prod Rep
Heterologous biosynthesis has emerged as a viable route to access the beneficial properties of natural products. This development primarily owes to the difficulties encountered when using traditional methods of natural product discovery and productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e3d56d7790326c42b14223f370cb23
https://pubmed.ncbi.nlm.nih.gov/21060956
https://pubmed.ncbi.nlm.nih.gov/21060956