Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brett A. Barbaro"'
Autor:
Ludovic Autin, Brett A. Barbaro, Andrew I. Jewett, Axel Ekman, Shruti Verma, Arthur J. Olson, David S. Goodsell
Publikováno v:
QRB Discovery, Vol 3 (2022)
Models of insulin secretory vesicles from pancreatic beta cells have been created using the cellPACK suite of tools to research, curate, construct and visualise the current state of knowledge. The model integrates experimental information from proteo
Externí odkaz:
https://doaj.org/article/b4a4b94ef2a247e4b65ec7d554c42962
Autor:
Brett A. Barbaro, Anjalika Chongtham, Judith Purcell, Shane A. Worthge, Adeela Syed, Tamas Lukacsovich, Douglas J. Bornemann, Namita Agrawal, Theodore M Chin, John Burke, J. Lawrence Marsh
Publikováno v:
Hum Mol Genet
Human molecular genetics, vol 29, iss 4
Human molecular genetics, vol 29, iss 4
Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates. Here we ask whether expanded polyQ is sufficient to cause
Integrative computational modeling is currently the method of choice for studying the detailed mesoscale molecular structure of cellular environments. However, current methods are highly compute intensive and require extensive and diverse domain know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c745fd25bc431cfbbc7a9c55645e486
https://europepmc.org/articles/PMC6456043/
https://europepmc.org/articles/PMC6456043/
Autor:
Shane A. Worthge, Olga A. Morozova, David W. Colby, Doug J. Bornemann, Namita Agrawal, J. Lawrence Marsh, Judith Purcell, Tamas Lukacsovich, Andrea Caricasole, Brett A. Barbaro, Wan Song, Andreas Weiss, John Burke
Publikováno v:
Human Molecular Genetics. 24:913-925
Although Huntington's disease is caused by the expansion of a CAG triplet repeat within the context of the 3144-amino acid huntingtin protein (HTT), studies reveal that N-terminal fragments of HTT containing the expanded PolyQ region can be produced
Publikováno v:
Journal of virology. 91(12)
The simian virus 40 (SV40) in vitro replication system was previously used to demonstrate that the human polymerase (Pol) α-primase complex preferentially initiates DNA synthesis at pyrimidine-rich trinucleotide sequences. However, it has been repor
Autor:
J. Lawrence Marsh, Yu-Chiau Shyu, Kuan Yu Liu, Yijuang Chern, Leslie M. Thompson, Yuan Ta Lin, Che Kun James Shen, Brett A. Barbaro
Publikováno v:
Liu, KY; Shyu, YC; Barbaro, BA; Lin, YT; Chern, Y; Thompson, LM; et al.(2015). Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease. Human Molecular Genetics, 24(6), 1602-1616. doi: 10.1093/hmg/ddu574. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/80k0b04n
Human molecular genetics, vol 24, iss 6
Human molecular genetics, vol 24, iss 6
© The Author 2014. Published by Oxford University Press. All rights reserved. Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the cytoplasm, nuclei and axons of neurons is a hallmark of Huntington's disease (HD), although how the
Autor:
Shane A. Worthge, Adeela Syed, Letizia Magnoni, Michela Camarri, Liliana B. Menalled, J. Lawrence Marsh, Andrea Caricasole, Marco Gianfriddo, Enrica Diodato, Tamas Lukacsovich, Ruth Luthi-Carter, Ozgun Gokce, Judy Purcell, Marianne R. Smith, Luisa Massai, Sylvie Ramboz, Stephen R. Wei, Davide Franceschini, Russell J. Thomas, Giuseppe Pollio, G Westerberg, Bernard Landwehrmeyer, Carla Scali, Brett A. Barbaro, Carol Murphy, Sarah J. Tabrizi
Publikováno v:
Human molecular genetics, vol 23, iss 11
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945f412d35a8fd0b971b3108edc54b4
https://escholarship.org/uc/item/91m8n212
https://escholarship.org/uc/item/91m8n212
Autor:
Brett A. Barbaro, Andrea E. Prack, Peter A. Bullock, Kodangattil Sreekumar, Danielle R. Winters
Publikováno v:
Journal of Virology. 74:8601-8613
Initiation of DNA replication is a complicated and highly regulated process that takes place during the S phase of the cell cycle. Progress in understanding initiation events in eukaryotes includes the identification of many of the factors that catal
Autor:
Wan, Song, Marianne R, Smith, Adeela, Syed, Tamas, Lukacsovich, Brett A, Barbaro, Judith, Purcell, Doug J, Bornemann, John, Burke, J Lawrence, Marsh
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1017
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The HD gene encodes the huntingtin protein (HTT) that contains polyglutamine tracts of variable length. Expansions of the CAG repeat near the amino terminus to encode 40 o