Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Brett A Kaufman"'
Autor:
Jitendra S Kanshana, Polly E Mattila, Michael C Ewing, Ashlee N Wood, Gabriele Schoiswohl, Anna C Meyer, Aneta Kowalski, Samantha L Rosenthal, Sebastien Gingras, Brett A Kaufman, Ray Lu, Daniel E Weeks, Stephen T McGarvey, Ryan L Minster, Nicola L Hawley, Erin E Kershaw
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0251895 (2021)
Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRFR457Q] is strongly
Externí odkaz:
https://doaj.org/article/89877e3193b84a7a9605cc11de25289c
Autor:
Cody A Rutledge, Takuto Chiba, Kevin Redding, Cameron Dezfulian, Sunder Sims-Lucas, Brett A Kaufman
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0237292 (2020)
AimMouse models of sudden cardiac arrest are limited by challenges with surgical technique and obtaining reliable venous access. To overcome this limitation, we sought to develop a simplified method in the mouse that uses ultrasound-guided injection
Externí odkaz:
https://doaj.org/article/ff04b416d3644a6fb335cdf2730f0b98
PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.
Autor:
Marta Bueno, Daniel Zank, Ivette Buendia-Roldán, Kaitlin Fiedler, Brenton G Mays, Diana Alvarez, John Sembrat, Brian Kimball, Jordan K Bullock, James L Martin, Mehdi Nouraie, Brett A Kaufman, Mauricio Rojas, Annie Pardo, Moisés Selman, Ana L Mora
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218003 (2019)
We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although inc
Externí odkaz:
https://doaj.org/article/68541fa065c84c808d41a0a0f14db3e0
Autor:
Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi, Yanxia Chu, Yingze Zhang, Sylvie Bannwarth, Véronique Paquis-Flucklinger, Lea Harrington, Sruti Shiva, Michael J Jurczak, Robert M O'Doherty, Brett A Kaufman
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0203101 (2019)
Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whe
Externí odkaz:
https://doaj.org/article/0257a012d4cf43d6868160c11cb2075b
Autor:
Manti Guha, Satish Srinivasan, F Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A Kaufman, M Rebecca Glineburg, JiKang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G Avadhani
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206897 (2018)
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading
Externí odkaz:
https://doaj.org/article/b35d722221c947ccb0b5e205f287aa71
Autor:
Sarah A. Ware, Corrine R. Kliment, Luca Giordano, Kevin M. Redding, William L. Rumsey, Stewart Bates, Yingze Zhang, Frank C. Sciurba, S. Mehdi Nouraie, Brett A. Kaufman
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract The question addressed by the study Good biological indicators capable of predicting chronic obstructive pulmonary disease (COPD) phenotypes and clinical trajectories are lacking. Because nuclear and mitochondrial genomes are damaged and rel
Externí odkaz:
https://doaj.org/article/ad97e0d7548243e9b1bfbdb12525f3ef
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52830 (2012)
The mechanisms that ensure the removal of damaged mitochondrial proteins and lipids are critical for the health of the cell, and errors in these pathways are implicated in numerous degenerative diseases. We recently uncovered a new pathway for the se
Externí odkaz:
https://doaj.org/article/ae954a7c6a6144ae9dcbc754b2b8f40a
Autor:
Cody A. Rutledge, Claudia Lagranha, Takuto Chiba, Kevin Redding, Donna B. Stolz, Eric Goetzman, Sunder Sims-Lucas, Brett A. Kaufman
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 4, Iss , Pp 100034- (2023)
Cardiac arrest (CA) causes high mortality due to multi-system organ damage attributable to ischemia-reperfusion injury. Recent work in our group found that among diabetic patients who experienced cardiac arrest, those taking metformin had less eviden
Externí odkaz:
https://doaj.org/article/e1a713b4f1ec4938b59f75d481a7de4c
Autor:
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract 8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination a
Externí odkaz:
https://doaj.org/article/6865606e68fe4a83a2797cb46fc67eee
Autor:
Manish Verma, Lily Francis, Britney N. Lizama, Jason Callio, Gabriella Fricklas, Kent Z.Q. Wang, Brett A. Kaufman, Leonardo D’Aiuto, Donna B. Stolz, Simon C. Watkins, Vishwajit L. Nimgaonkar, Alejandro Soto-Gutierrez, Amy Goldstein, Charleen T. Chu
Publikováno v:
The American Journal of Pathology. 193:201-212
Mutations in POLG, the gene encoding the catalytic subunit of DNA polymerase gamma, result in clinical syndromes characterized by mitochondrial DNA (mtDNA) depletion in affected tissues with variable organ involvement. The brain is one of the most af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d6e02d99250878843e8d43be47e6e9
https://doi.org/10.1016/j.ajpath.2022.11.002
https://doi.org/10.1016/j.ajpath.2022.11.002