Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Brett A Graham"'
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Publikováno v:
eLife, Vol 8 (2019)
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pa
Externí odkaz:
https://doaj.org/article/e0cd9725113d49e9aa0bf5e1f78d7155
Autor:
Tyler J. Browne, Kelly M. Smith, Mark A. Gradwell, Christopher V. Dayas, Robert J. Callister, David I. Hughes, Brett A. Graham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information from the body. The existence and function of a substantial axon collateral network,
Externí odkaz:
https://doaj.org/article/ec93f78f34ca4384b30c43e37a0ef70a
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is likely mediated in part through the dense projections to the PVT from hypothalamic peptide transmitter systems suc
Externí odkaz:
https://doaj.org/article/8e4a99efe4924ae9a87202cda71b35fd
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to advancing analgesia. We highlight recent advances showing that functionally discrete popula
Externí odkaz:
https://doaj.org/article/eab843e9807a486d91ad563f601bbef9
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
The tight regulation of sleep/wake states is critical for mental and physiological wellbeing. For example, dysregulation of sleep/wake systems predisposes individuals to metabolic disorders such as obesity and psychiatric problems, including depressi
Externí odkaz:
https://doaj.org/article/d98d7c49c09448898e64462549f6500a
Autor:
Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher, Laura M. Stanton, Nicholas J. Burton, Amy J. Pearl, Gavan P. McNally, Jaideep S. Bains, Tamás Füzesi, Brett A. Graham, Elizabeth E. Manning, Christopher V. Dayas
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motiva
Externí odkaz:
https://doaj.org/article/e892cfa1b0cc4b1c91328ec5064f90fa
Autor:
Robert J Callister, Brett A Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 3 (2010)
In this review we provide an overview of key in vivo experiments, undertaken in the cat spinal cord in the 1950s and 1960s, and point out their contributions to our present understanding of glycine receptor (GlyR) function. Importantly, some of these
Externí odkaz:
https://doaj.org/article/0154d4e202194aa9aa726fa4650f1d4e
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Makayla S. Lancaster, Byungwook Kim, Emma H. Doud, Mason D. Tate, Ahmad D. Sharify, Hongyu Gao, Duojiao Chen, Ed Simpson, Patrick Gillespie, Xiaona Chu, Marcus J. Miller, Yue Wang, Yunlong Liu, Amber L. Mosley, Jungsu Kim, Brett H. Graham
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113241- (2023)
Summary: Lysine succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the tricarboxylic acid cycle. Deficiency of succinyl-CoA synthetase (SCS), the tricarboxylic acid cycle enzyme catalyzing the inte
Externí odkaz:
https://doaj.org/article/3667fe089082442185bcfa19a5753f0c
Autor:
Wenjing Yin, Derrick Brittain, Jay Borseth, Marie E. Scott, Derric Williams, Jedediah Perkins, Christopher S. Own, Matthew Murfitt, Russel M. Torres, Daniel Kapner, Gayathri Mahalingam, Adam Bleckert, Daniel Castelli, David Reid, Wei-Chung Allen Lee, Brett J. Graham, Marc Takeno, Daniel J. Bumbarger, Colin Farrell, R. Clay Reid, Nuno Macarico da Costa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Electron microscopy (EM) is the gold standard for biological ultrastructure but acquisition speed is slow, making it unsuitable for large volumes. Here the authors present a parallel imaging pipeline for continuous autonomous imaging with six transmi
Externí odkaz:
https://doaj.org/article/1636c301c307427c8f6136be5b12c53a