Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brett A Duguay"'
Autor:
Eric S Pringle, Brett A Duguay, Maxwell P Bui-Marinos, Rory P Mulloy, Shelby L Landreth, Krishna Swaroop Desireddy, Stacia M Dolliver, Shan Ying, Taylor Caddell, Trinity H Tooley, Patrick D Slaine, Stephen L Bearne, Darryl Falzarano, Jennifer A Corcoran, Denys A Khaperskyy, Craig McCormick
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010832 (2022)
There is an outstanding need for broadly acting antiviral drugs to combat emerging viral diseases. Here, we report that thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2. 6-Thioguanine (6-TG) disrupted early stages
Externí odkaz:
https://doaj.org/article/e4051cc5cb3d4a36881ae54bc20ae244
Autor:
Brett A. Duguay, Adrian Herod, Eric S. Pringle, Susan M. A. Monro, Marc Hetu, Colin G. Cameron, Sherri A. McFarland, Craig McCormick
Publikováno v:
Viruses, Vol 14, Iss 1, p 110 (2022)
Photodynamic inactivation (PDI) employs a photosensitizer, light, and oxygen to create a local burst of reactive oxygen species (ROS) that can inactivate microorganisms. The botanical extract PhytoQuinTM is a powerful photosensitizer with antimicrobi
Externí odkaz:
https://doaj.org/article/6a7e79cfefcb4b6681100f6fd0819f71
Publikováno v:
The Journal of Immunology. 204:2021-2032
Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6af78abf910fcb9b289857c8073af95
https://doi.org/10.4049/jimmunol.1800658
https://doi.org/10.4049/jimmunol.1800658
Autor:
Andrea L.-A. Monjo, Eric S. Pringle, Mackenzie Thornbury, Brett A. Duguay, Susan M. A. Monro, Marc Hetu, Danika Knight, Colin G. Cameron, Sherri A. McFarland, Craig McCormick
Publikováno v:
Viruses, Vol 10, Iss 10, p 532 (2018)
Herpes simplex virus (HSV) infections can be treated with direct acting antivirals like acyclovir and foscarnet, but long-term use can lead to drug resistance, which motivates research into broadly-acting antivirals that can provide a greater genetic
Externí odkaz:
https://doaj.org/article/10cc3dc6be2d472ab388f2886e5f85df
Autor:
Michel Roberge, Denys A. Khaperskyy, Mariel Kleer, Brett A. Duguay, Patrick D Slaine, Craig McCormick, Aruna D. Balgi, Eric S. Pringle, Shan Ying, Eileigh Kadijk
Publikováno v:
Journal of Virology
Secreted and transmembrane proteins are synthesized in the endoplasmic reticulum (ER), where they are folded and modified prior to transport. Many viruses rely on the ER for the synthesis and processing of viral glycoproteins that will ultimately be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e4922e44f95b37cc6bb409a439778b
https://pubmed.ncbi.nlm.nih.gov/33762409
https://pubmed.ncbi.nlm.nih.gov/33762409
Autor:
Michel Roberge, Brett A. Duguay, Mariel Kleer, Patrick D Slaine, Aruna D. Balgi, Eric S. Pringle, Craig McCormick, Denys A. Khaperskyy, Eileigh Kadijk, Shan Ying
Enveloped viruses, including influenza A viruses (IAVs) and coronaviruses (CoVs), utilize the host cell secretory pathway to synthesize viral glycoproteins and direct them to sites of assembly. Using an image-based high-content screen, we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a06a665cc30ded3d0bba5547315d21
https://doi.org/10.1101/2020.09.30.319863
https://doi.org/10.1101/2020.09.30.319863
Publikováno v:
Journal of Leukocyte Biology. 104:587-596
Mast cells are important immune cells that have significant roles in mediating allergy and asthma. Therefore, studying the molecular mechanisms regulating these and other processes in mast cells is important to elucidate. Methods such as lipofection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd04af5f5a11abc29a9aec3acf249cc
https://doi.org/10.1002/jlb.3ta0517-192r
https://doi.org/10.1002/jlb.3ta0517-192r
Autor:
Mackenzie Thornbury, Craig McCormick, Brett A. Duguay, Susan Monro, Colin G. Cameron, A.L. Monjo, Marc Hetu, Eric S. Pringle, Sherri A. McFarland, Danika Knight
Publikováno v:
Viruses
Volume 10
Issue 10
Viruses, Vol 10, Iss 10, p 532 (2018)
Volume 10
Issue 10
Viruses, Vol 10, Iss 10, p 532 (2018)
Herpes simplex virus (HSV) infections can be treated with direct acting antivirals like acyclovir and foscarnet, but long-term use can lead to drug resistance, which motivates research into broadly-acting antivirals that can provide a greater genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e02b4e80bf95dfd551c6fb1bb5427e
Autor:
Michal Caspi Tal, Sabine Lang, Brett A. Duguay, Nuno Raimundo, Megan Bestwick, William Khoury-Hanold, Donna A. MacDuff, A. Phillip West, Susan M. Kaech, Gerald S. Shadel, Robert E. Means, Matthew M. Staron, Cristiana M. Pineda, Akiko Iwasaki, James R. Smiley
Publikováno v:
Nature
Mitochondrial DNA (mtDNA) is normally present at thousands of copies per cell and is packaged into several hundred higher-order structures termed nucleoids. The abundant mtDNA-binding protein TFAM (transcription factor A, mitochondrial) regulates nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4748fb8052236805dd6e2c64f1ab18d
https://doi.org/10.1038/nature14156
https://doi.org/10.1038/nature14156
Autor:
Shayla A. Duley, Brett A. Duguay, Alina Ponomarev, Holly A. Saffran, Heather E. Eaton, James R. Smiley
Infection with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host cells. It is known that a mitochondrial isoform of the viral alkaline nuclease (UL12) called UL12.5 triggers this process. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378fc9bf7f18ff126d980bfe23c16d07
https://europepmc.org/articles/PMC3958086/
https://europepmc.org/articles/PMC3958086/