Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Brett A, Howell"'
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4
Autor:
Grant Generaux, Vinal V. Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A. Howell, Scott Q. Siler, Paul B. Watkins, Hugh A. Barton, Michael D. Aleo, Lisl K. M. Shoda
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Many compounds that appear promising in preclinical species, fail in human clinical trials due to safety concerns. The FDA has strongly encouraged the application of modeling in drug development to improve product safety. This study illustra
Externí odkaz:
https://doaj.org/article/828b1d4c830842609ef4d255b6b2b62b
Autor:
Yang, James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9692
Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f5d2d21d59cdb846ddbe216b495d7438
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 188(1)
Calcitonin gene-related peptide (CGRP) signaling inhibitors have shown efficacy in both the acute and preventive treatment of migraine. Telcagepant, a first-generation CGRP receptor antagonist, was effective but failed in clinical trials due to hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa987be0696be48efef7224cc2a9008d
https://pubmed.ncbi.nlm.nih.gov/35556143
https://pubmed.ncbi.nlm.nih.gov/35556143
Autor:
Brett A. Howell, Robert M. Berman, Diane M. Longo, Vladimir Coric, Irfan Qureshi, Lisl K.M. Shoda
Publikováno v:
Toxicological Sciences
For patients with amyotrophic lateral sclerosis who take oral riluzole tablets, approximately 50% experience alanine transaminase (ALT) levels above upper limit of normal (ULN), 8% above 3× ULN, and 2% above 5× ULN. BHV-0223 is a novel 40 mg rapidl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e674cd81dbc9b548ae296e83ed9eed32
http://europepmc.org/articles/PMC7253195
http://europepmc.org/articles/PMC7253195
Autor:
Alan E. Fryar, Mohamed Farhaoui, Brett Andrew Howell, Lhoussaine Bouchaou, Lahcen Benaabidate
Publikováno v:
Hydrogeology Journal. 27:1693-1710
Springs in the Middle Atlas region of Morocco are important public water supplies, but their responses to storm-event and seasonal forcings have received only limited study. From March 2014 to May 2015, water temperature was measured hourly at three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2374fe26b3e60b9c793083e2addede8
https://doi.org/10.1007/s10040-019-01945-w
https://doi.org/10.1007/s10040-019-01945-w
Autor:
Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid dispos
Externí odkaz:
https://doaj.org/article/64259af463dc478a95f0ad84590ccafa
Autor:
Abhijit Mukherjee, Sunil Mehta, Lahcen Benaabidate, Brett A. Howell, Joshua M. Barna, Alan E. Fryar
Publikováno v:
Springer Transactions in Civil and Environmental Engineering ISBN: 9789811603938
Since the 1960s, the stable isotopes oxygen-18 and deuterium have become widely used for delineating sources and timing of precipitation, identifying effects of evaporation and apportioning end-member contributions in streamflow and groundwater. Duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41cf475d2dd449e8c0af186b3c5aea00
https://doi.org/10.1007/978-981-16-0394-5_16
https://doi.org/10.1007/978-981-16-0394-5_16
Autor:
Yeshitila Gebremichael, Evren Atillasoy, Brett A. Howell, F. Jay Murray, Kyunghee Yang, Hartmut Jaeschke, Edwin Kuffner, John C.K. Lai, Gary Eichenbaum, Cathy K. Gelotte, Daniele Wikoff, David Jacobson-Kram
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 118
In 2019, the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. The objective of the analysis herein was to inform this review by assessing whether variability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0ff4d6401fcd0a95ae9bd76efa460e
https://pubmed.ncbi.nlm.nih.gov/33153971
https://pubmed.ncbi.nlm.nih.gov/33153971
Autor:
Edwin Kuffner, Samuel M. Cohen, Milind Deore, Andrew D. Monnot, Evren Atillasoy, Gary Eichenbaum, Cathy K. Gelotte, Anne Hermanowski-Vosatka, Suren B. Bandara, Michael Kovochich, Jerry F. Hardisty, Brett A. Howell, Suresh Kumar Pitchaiyan, F. Jay Murray, Kyunghee Yang, John C.K. Lai, Yeshitila Gebremichael, Kenneth M. Unice, David Jacobson-Kram
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 118
In 2019 the California Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen, including an assessment of the long-term rodent carcinogenicity and tumor initiation/promotion s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf03e183693fd3bd219f6d08fafae6d
https://pubmed.ncbi.nlm.nih.gov/33039518
https://pubmed.ncbi.nlm.nih.gov/33039518