Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Brett Lomenick"'
Autor:
Jeff Jones, Elliot J. MacKrell, Ting-Yu Wang, Brett Lomenick, Michael L. Roukes, Tsui-Fen Chou
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background The analysis of mass spectrometry-based quantitative proteomics data can be challenging given the variety of established analysis platforms, the differences in reporting formats, and a general lack of approachable standardized pos
Externí odkaz:
https://doaj.org/article/de134690c952413181e2b4da22f9a645
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104756- (2022)
Summary: The removal of the N-terminal formyl group on nascent proteins by peptide deformylase (PDF) is the most prevalent protein modification in bacteria. PDF is a critical target of antibiotic development; however, its role in bacterial physiology
Externí odkaz:
https://doaj.org/article/b29a3f98361f4d22bc538b3bcbf10a0b
Autor:
Chun-Shik Shin, Shuxia Meng, Spiros D. Garbis, Annie Moradian, Robert W. Taylor, Michael J. Sweredoski, Brett Lomenick, David C. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.
Externí odkaz:
https://doaj.org/article/8a65c368ecc04a4481d331a0a80d8431
Autor:
Grace Z. Wang, Elizabeth A. Warren, Allison L. Haas, Andrea Sánchez Peña, Megan R. Kiedrowski, Brett Lomenick, Tsui-Fen Chou, Jennifer M. Bomberger, David A. Tirrell, Dominique H. Limoli
Publikováno v:
bioRxiv
Coinfection with two notorious opportunistic pathogens, the Gram-negativePseudomonas aeruginosaand Gram-positiveStaphylococcus aureus, dominates chronic pulmonary infections. While coinfection is associated with poor patient outcomes, the interspecie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3546afd9ce8f125126284097e1e002
https://doi.org/10.1101/2023.01.29.526047
https://doi.org/10.1101/2023.01.29.526047
Autor:
Alina Guna, Taylor A. Stevens, Alison J. Inglis, Joseph M. Replogle, Theodore K. Esantsi, Gayathri Muthukumar, Kelly C. L. Shaffer, Maxine L. Wang, Angela N. Pogson, Jeff J. Jones, Brett Lomenick, Tsui-Fen Chou, Jonathan S. Weissman, Rebecca M. Voorhees
Publikováno v:
Science (New York, N.Y.). 378(6617)
In the mitochondrial outer membrane, tail-anchored (TA) proteins play critical roles in cytoplasmic-mitochondrial communication. Using genome-wide CRISPRi screens, we identify factors involved in mitochondrial TA biogenesis in human cells. We show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf1c0e463a28b3a74f91ec606281a0
https://pubmed.ncbi.nlm.nih.gov/36264797
https://pubmed.ncbi.nlm.nih.gov/36264797
Autor:
Chieh Chen, Brett Lomenick, Min Chai, Wilson Huang, Jessie Chu, Laurent Vergnes, Reid O’Brien Johnson, Ajay A. Vashisht, Randall M. Chin, Melissa M. Dix, Gabriel Simon, Xudong Fu, Jenny C. Link, Heejun Hwang, Xiang Yin, Stéphanie C. de Barros, Daniel Braas, Nahn Hee Diane Kim, Yibin Wang, Steven M. Dubinett, Michael A. Teitell, Oliver Fiehn, Meisheng Jiang, Benjamin F. Cravatt, James A. Wohlschlegel, Joseph A. Loo, Karen Reue, Jing Huang
Aging is a complex process that is directly related to human health and disease. The extraordinary finding that aging is malleable, as shown in model organisms whose life and health spans are extended by specific gene mutations or dietary or pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c4778bd35323664c7ac99f97892f9
https://doi.org/10.1101/2022.10.10.511641
https://doi.org/10.1101/2022.10.10.511641
Autor:
Yaru Zhang, Marco Jost, Ryan A. Pak, Daniel Lu, Jing Li, Brett Lomenick, Spiros D. Garbis, Chi-Ming Li, Jonathan S. Weissman, James Russell Lipford, Raymond J. Deshaies
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Cop9 signalosome (CSN) regulates the function of cullin–RING E3 ubiquitin ligases (CRLs) by deconjugating the ubiquitin-like protein NEDD8 from the cullin subunit. To understand the physiological impact of CSN function on the CRL network and cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc36e57f6f93f9157316c013a44750ab
https://pubmed.ncbi.nlm.nih.gov/36037385
https://pubmed.ncbi.nlm.nih.gov/36037385
Genome regulation involves complex and highly regulated protein interactions that are often mediated through post-translational modifications (PTMs). SUMOylation – the covalent attachment of thesmallubiquitin-likemodifier (SUMO) – is a conserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665b7c284430db33956f99254e22beab
https://doi.org/10.1101/2022.08.15.504007
https://doi.org/10.1101/2022.08.15.504007
Publikováno v:
Molecular microbiology. 118(4)
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that often encounters hypoxic/anoxic environments within the host, which increases its tolerance to many conventional antibiotics. Towards identifying novel treatments, we explored the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a89bed531899444635845c0afe8b6d
https://pubmed.ncbi.nlm.nih.gov/36271736
https://pubmed.ncbi.nlm.nih.gov/36271736
Autor:
Shan Li, Sean Ekins, Feng Wang, Steven Q. Le, Tsui-Fen Chou, Chelsee Sauni, Brett Lomenick, Xiaoyi Zhang, Patricia I. Dickson, Shih Hsin Kan, Srikanth Singamsetty, Jill Wood, Derek R. Moen
Publikováno v:
Molecular Pharmaceutics. 18:214-227
There is currently no cure or effective treatment available for mucopolysaccharidosis type IIID (MPS IIID, Sanfilippo syndrome type D), a lysosomal storage disorder (LSD) caused by the deficiency of α-N-acetylglucosamine-6-sulfatase (GNS). The clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd63ec9bdd3841a50bd5fb7d1ce7212f
https://doi.org/10.1021/acs.molpharmaceut.0c00831
https://doi.org/10.1021/acs.molpharmaceut.0c00831