Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brett Jeffery"'
Autor:
Steven L. Taylor, W. Marty Blom, Marie Y. Meima, Joseph L. Baumert, Marie-Claude Robert, Niels B. Lucas Luijckx, Benjamin C. Remington, Brett Jeffery, Geert F. Houben
Publikováno v:
Food Control. 124:107850
Allergenic food particles (typically ~0.5–5 mm) may unintentionally end up in food products during production and can pose a risk for the allergic consumer. A single particle can provoke allergic symptoms in an allergic consumer when the dose of al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb58686382bc9fcb19856fab0b091e1
https://doi.org/10.1016/j.foodcont.2020.107850
https://doi.org/10.1016/j.foodcont.2020.107850
Autor:
Bas J. Blaauboer, Gareth Edwards, Brett Jeffery, Jossie A. Garthoff, Mardas Daneshian, Bobbie Bradford, Cyrille Krul, Andrew Cockburn, Alan R. Boobis, Jeroen Schuermans, Anne Constable
Publikováno v:
Food and Chemical Toxicology. 91:19-35
Toxicology and safety assessment are changing and require new strategies for evaluating risk that are less depending on apical toxicity endpoints in animal models and relying more on knowledge of the mechanism of toxicity. This manuscript describes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d396dc481b4340688f73003be74a59d
https://doi.org/10.1016/j.fct.2016.02.019
https://doi.org/10.1016/j.fct.2016.02.019
Autor:
Maria Teresa Ortega, Juraj Koči, Nancy A. Monteiro-Riviere, Brett Jeffery, Kyoungju Choi, Jim E. Riviere
Publikováno v:
International Journal of Veterinary Health Science & Research. :88-103
In vitro test methods are used primarily for rapid screening of chemicals based on mechanistic understanding of toxicity to predict hazards and potential risks. We investigated organ-specific oxidative stress and the molecular mechanism of toxicity u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a8dbdc3e14c0e69bc53dee3ab94ff5
https://doi.org/10.19070/2332-2748-1600022
https://doi.org/10.19070/2332-2748-1600022
Publikováno v:
Journal of Applied Toxicology. 36:189-198
We developed an in vitro method to assess pet food ingredients safety. Canine bone marrow-derived mesenchymal stem cells (BMSC) were differentiated into enterocyte-like cells (ELC) to assess toxicity in cells representing similar patterns of exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ca7f5a6401237567a49495e0806fd6
https://doi.org/10.1002/jat.3158
https://doi.org/10.1002/jat.3158
Publikováno v:
Food and Chemical Toxicology. 78:105-115
This research aimed to develop in vitro methods to assess hazard of canine food ingredients. Canine hepatocytes were harvested and cell viability of clove-leaf oil (CLO), eugenol (EUG), lemongrass oil (LGO), guanosine monophosphate (GMP), inosine mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c365c65028308cf9aedfa88dd0adc3d4
https://doi.org/10.1016/j.fct.2015.02.003
https://doi.org/10.1016/j.fct.2015.02.003
Publikováno v:
Toxicology letters. 241
In vitro cell culture systems are a useful tool to rapidly assess the potential safety or toxicity of chemical constituents of food. Here, we investigated oxidative stress and organ-specific antioxidant responses by 7 potential dietary ingredients us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadfb981a15553124bc1c7b18ac87fef
https://pubmed.ncbi.nlm.nih.gov/26602166
https://pubmed.ncbi.nlm.nih.gov/26602166
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 29(2)
In vitro models are useful tools to initially assess the toxicological safety hazards of food ingredients. Toxicities of cinnamaldehyde (CINA), cinnamon bark oil, lemongrass oil (LGO), thymol, thyme oil (TO), clove leaf oil, eugenol, ginger root extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3649194e0150f98c72cc8d110564a545
https://pubmed.ncbi.nlm.nih.gov/25458622
https://pubmed.ncbi.nlm.nih.gov/25458622
Autor:
Brett Jeffery, David R. Bell, Ruth A. Roberts, Abeer H. A. Amer, Abdullah Al Kholaifi, T. J. Gray
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 104(1)
Peroxisome proliferator-activated receptor alpha (PPARalpha) ligands evoke a profound mitogenic response in rodent liver, and the aim of this study was to characterize the kinetics of induction of DNA synthesis. The CAR ligand, 1,4-bis[2-(3,5-dichoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c60f64eaa2a63086357091494e1ddcf
https://pubmed.ncbi.nlm.nih.gov/18375545
https://pubmed.ncbi.nlm.nih.gov/18375545
Autor:
David A. Barrett, Ruth A. Roberts, David R. Bell, Neill J. Horley, Agharul I. Choudhury, David A. Kendall, Simon R. Tomlinson, P. Nicholas Shaw, T. J. Gray, Brett Jeffery, Mary Bruce
Publikováno v:
Archives of biochemistry and biophysics. 429(2)
We set out to find if the strain-specific, male-specific hepatic expression of Cyp4a protein in mouse was due to expression of Cyp4a12 and to understand the genetic basis for reported differences in expression. 12-Lauric acid hydroxylase (LAH) activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176aaa17216d66bb879ee0fbab9021d4
https://pubmed.ncbi.nlm.nih.gov/15313227
https://pubmed.ncbi.nlm.nih.gov/15313227
Publikováno v:
Toxicology. 148:29-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f7482e04eb040804757e0c3ac7104d
https://doi.org/10.1016/s0300-483x(00)90269-5
https://doi.org/10.1016/s0300-483x(00)90269-5