Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Brett, Langley"'
Autor:
Thong C. Ma, Brett Langley, Brian Ko, Na Wei, Irina G. Gazaryan, Neela Zareen, Darrell J. Yamashiro, Dianna E. Willis, Rajiv R. Ratan
Publikováno v:
Neurobiology of Disease, Vol 49, Iss , Pp 13-21 (2013)
Preventing neuronal death is a priority for treating neurological diseases. However, therapies that inhibit pathological neuron loss could promote tumorigenesis by preventing the physiological death of cancerous cells. To avert this, we targeted the
Externí odkaz:
https://doaj.org/article/7971307ece754a39ac7b44c1513b518f
Autor:
Sean Ekins, Nadia K. Litterman, Renée J.G. Arnold, Robert W. Burgess, Joel S. Freundlich, Steven J. Gray, Joseph J. Higgins, Brett Langley, Dianna E. Willis, Lucia Notterpek, David Pleasure, Michael W. Sereda, Allison Moore
Publikováno v:
F1000Research, Vol 4 (2015)
This brief review of current research progress on Charcot-Marie-Tooth (CMT) disease is a summary of discussions initiated at the Hereditary Neuropathy Foundation (HNF) scientific advisory board meeting on November 7, 2014. It covers recent published
Externí odkaz:
https://doaj.org/article/3547c770fb444cc882536cb3aeb4f6a8
Autor:
Zsofia Kutil, Brett Langley, Veronick Benoy, Sida Shen, Cristina Picci, Cyril Bařinka, Matthew B. Robers, Ludo Van Den Bosch, Alan P. Kozikowski, Jiří Pavlíček, Chad Zimprich, Guiping Zhang, Kseniya Ustinova, Maurício Temotheo Tavares
Publikováno v:
Journal of medicinal chemistry. 64(8)
Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eecb9ca5026a2d98cc63517f1fb871d
https://pubmed.ncbi.nlm.nih.gov/33830764
https://pubmed.ncbi.nlm.nih.gov/33830764
Autor:
Brett Langley, Alan P. Kozikowski, Sida Shen, Victor Wong, Glen T. Prusky, Christopher J. Costa, David C. Goldberg, Dianna E. Willis, Nazia M. Alam, Cristina Picci, Marion C. McKinnon, Michelle Swift
Publikováno v:
Experimental Neurology. 328:113281
Charcot-Marie-Tooth type 2A (CMT2A) peripheral neuropathy, the most common axonal form of CMT, is caused by dominantly inherited point mutations in the Mitofusin 2 (Mfn2) gene. It is characterized by progressive length-dependent degeneration of motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da9e1824a08db81781be9ce5e4ef6d2
https://doi.org/10.1016/j.expneurol.2020.113281
https://doi.org/10.1016/j.expneurol.2020.113281
Publikováno v:
Neuroscience Letters. 625:1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf23936625df14d2adfe11db35b6d2d5
https://doi.org/10.1016/j.neulet.2016.05.052
https://doi.org/10.1016/j.neulet.2016.05.052
Autor:
Irina G. Gazaryan, Anatoly A. Starkov, Sama F. Sleiman, Brett Langley, Julie K. Andersen, Camille Brochier, Ambreena Siddiq, Manuela Basso, Gregory J. Riggins, Thong C. Ma, Hossein Aleyasin, Susan Bane, Saravanan S. Karuppagounder, Rajiv R. Ratan, Shankar J. Chinta, Renée E. Haskew-Layton, Amit Kumar
Publikováno v:
Antioxidants & Redox Signaling. 22:121-134
Aims: Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9bec57c7e47c9879e0c6a9da366dd4
https://doi.org/10.1089/ars.2013.5595
https://doi.org/10.1089/ars.2013.5595
Publikováno v:
eNeuro
Visual Abstract
Damage to the CNS results in neuronal and axonal degeneration, and subsequent neurological dysfunction. Endogenous repair in the CNS is impeded by inhibitory chemical and physical barriers, such as chondroitin sulfate proteoglyca
Damage to the CNS results in neuronal and axonal degeneration, and subsequent neurological dysfunction. Endogenous repair in the CNS is impeded by inhibitory chemical and physical barriers, such as chondroitin sulfate proteoglyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182c03ded3f5d0551e08fc926457c5d9
https://pubmed.ncbi.nlm.nih.gov/29497702
https://pubmed.ncbi.nlm.nih.gov/29497702
Autor:
Sharmina Miller-Randolph, Andrew P. Tosolini, Ryan Passino, Victor Wong, Giampietro Schiavo, Leif A. Havton, Roman J. Giger, James N. Sleigh, Amar N. Kar, Alicia L. Hawthorne, Paul Brito-Vargas, Cristina Picci, Seung Joon Lee, Jeffery L. Twiss, Deanna S. Smith, Brett Langley, John Craver, Liang Shi, Ashley L. Kalinski, Dianna E. Willis
Publikováno v:
The Journal of Cell Biology
Van Den Bosch highlights the discovery by Kalinski et al. of Miro1 as an HDAC6 substrate that regulates mitochondrial trafficking in neurons and axon regeneration.
Myelin-associated glycoprotein and chondroitin sulfate proteoglycans in the extra
Myelin-associated glycoprotein and chondroitin sulfate proteoglycans in the extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff5989a1a5873efca49b789a2a6bef1
https://pubmed.ncbi.nlm.nih.gov/31118238
https://pubmed.ncbi.nlm.nih.gov/31118238
Autor:
Camille Brochier, Kathryn McLaughlin, Gretel Dennis, Rajiv R. Ratan, Giovanni Coppola, Brett Langley, Mark A. Rivieccio
Publikováno v:
The Journal of Neuroscience. 33:8621-8632
Histone deacetylase (HDAC) inhibitors have been used to promote neuronal survival and ameliorate neurological dysfunction in a host of neurodegenerative disease models. The precise molecular mechanisms whereby HDAC inhibitors prevent neuronal death a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41552e8f0853cceac9f72abadf097c00
https://doi.org/10.1523/jneurosci.5214-12.2013
https://doi.org/10.1523/jneurosci.5214-12.2013
Autor:
Victor Wong, Brett Langley
Traumatic brain injury (TBI) contributes to nearly a third of all injury-related deaths in the United States. For survivors of TBI, depending on severity, patients can be left with devastating neurological disabilities that include impaired cognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027214692321ea147d3c7c33d9c0bdf2
https://europepmc.org/articles/PMC4915732/
https://europepmc.org/articles/PMC4915732/
