Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brett, Jorgensen"'
Autor:
Harbani K. Malik-Chaudhry, Kirthana Prabhakar, Harshad S. Ugamraj, Andrew A. Boudreau, Benjamin Buelow, Kevin Dang, Laura M. Davison, Katherine E. Harris, Brett Jorgensen, Heather Ogana, Duy Pham, Ute Schellenberger, Wim Van Schooten, Roland Buelow, Suhasini Iyer, Nathan D. Trinklein, Udaya S. Rangaswamy
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents,
Externí odkaz:
https://doaj.org/article/54c6dadc1dc04e3c82d81639cfba9a39
Autor:
Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow, Shelley Force Aldred
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based bi
Externí odkaz:
https://doaj.org/article/6a706cdfcb4649ab82279f4b31c5c13b
Autor:
Katherine E. Harris, Shelley Force Aldred, Laura M. Davison, Heather Anne N. Ogana, Andrew Boudreau, Marianne Brüggemann, Michael Osborn, Biao Ma, Benjamin Buelow, Starlynn C. Clarke, Kevin H. Dang, Suhasini Iyer, Brett Jorgensen, Duy T. Pham, Payal P. Pratap, Udaya S. Rangaswamy, Ute Schellenberger, Wim C. van Schooten, Harshad S. Ugamraj, Omid Vafa, Roland Buelow, Nathan D. Trinklein
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique syst
Externí odkaz:
https://doaj.org/article/0e55864017b746d182977ff0f5e8bf28
Autor:
Ivan H Chan, Dennis Van Hoof, Marina Abramova, Melissa Bilardello, Elliot Mar, Brett Jorgensen, Scott McCauley, Harminder Bal, Martin Oft, Peter Van Vlasselaer, John B Mumm
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156229 (2016)
Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and humans. In
Externí odkaz:
https://doaj.org/article/15d2efc8347b456ab596f17ca099b999
Autor:
Derek C Marshall, Susan K Lyman, Scott McCauley, Maria Kovalenko, Rhyannon Spangler, Chian Liu, Michael Lee, Christopher O'Sullivan, Vivian Barry-Hamilton, Haben Ghermazien, Amanda Mikels-Vigdal, Carlos A Garcia, Brett Jorgensen, Arleene C Velayo, Ruth Wang, Joanne I Adamkewicz, Victoria Smith
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127063 (2015)
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a downstream effector and an upstream mediator of pathways involved in grow
Externí odkaz:
https://doaj.org/article/8613ab116c9b4cdeac17c58cadfebedf
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
Autor:
Harshad Ugamraj, Shelley Force Aldred, Katherine E. Harris, Suhasini Iyer, Brett Jorgensen, Payal Pratap, Ute Schellenberger, Kevin Dang, Nathan D. Trinklein, Omid Vafa, Starlynn Clarke, Udaya Rangaswamy, Duy Pham, Andrew Boudreau, Arun P. Wiita, Wim Van Schooten, Roland Buelow, Ben Buelow, Priya Choudhry
Publikováno v:
mAbs
T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more favorable properti
Autor:
Suhasini Iyer, Roland Buelow, Udaya Rangaswamy, Harbani K. Malik-Chaudhry, Kevin Dang, Katherine E. Harris, Duy Pham, Nathan D. Trinklein, Benjamin Buelow, Andrew Boudreau, Harshad Ugamraj, Brett Jorgensen, Wim Van Schooten, Heather Ogana, Laura Davison, Ute Schellenberger, Kirthana Prabhakar
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents,
Autor:
Laura Davison, Udaya Rangaswamy, Katherine M. Harris, Harshad Ugamraj, Ben Buelow, Duy Pham, Brett Jorgensen, Shelley Force Aldred, Aarti Balasubramani, Nathan D. Trinklein, Ute Schellenberger, Kevin Dang, Kirthana Prabhakar, Harbani Malik, Andrew Boudreau, Wim Van Schooten, Suhasini Iyer
Publikováno v:
Blood. 134:4070-4070
Introduction The restricted expression of CD19 in the B-cell lineage makes it an attractive target for the therapeutic treatment of B-cell malignancies. Many monoclonal antibodies and antibody drug conjugates targeting CD19 have been developed, inclu
Autor:
Laura Davison, Starlynn Clarke, Michael J. Osborn, Andrew Boudreau, Kevin Dang, Katherine E. Harris, Biao Ma, Ute Schellenberger, Heather Ogana, Omid Vafa, Nathan D. Trinklein, Roland Buelow, Marianne Brüggemann, Wim Van Schooten, Payal Pratap, Duy Pham, Brett Jorgensen, Benjamin Buelow, Harshad Ugamraj, Shelley Force Aldred, Udaya Rangaswamy, Suhasini Iyer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique syst
Autor:
Suhasini Iyer, Kyle J. Lorentsen, Starlynn Clarke, Ben Buelow, Katherine E. Harris, Nathan D. Trinklein, Brett Jorgensen, Duy Pham, Arun P. Wiita, Payal Pratap, Preethi Sankaran, Andrew Boudreau, Ute Schellenberger, Roland Buelow, Harshad Ugamraj, Shelley Force Aldred, Omid Vafa, Kevin Dang, Priya Choudhry, Wim Van Schooten, Udaya Rangaswamy
Publikováno v:
Cancer Research. 79:1554-1554
T-cell recruiting bispecific antibody (T-BsAb) treatment is an emerging cancer immunotherapy notable for its highly-specific tumor killing activity in humans. However, the success of T-BsAbs in the clinic has been limited due to cytokine-release rela