Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Autor: Williamson A; MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK., Norris DM; Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK., Yin X; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China., Broadaway KA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Moxley AH; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wilson EP; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Ahuja V; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Andersen MK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Arzumanyan Z; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Bonnycastle LL; Center for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bornstein SR; Department of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Bretschneider MP; Department of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Buchanan TA; Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine USC, Los Angeles, CA, USA., Chang YC; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei City, Taiwan.; Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei City, Taiwan., Chuang LM; Department of Internal Medicine, Division of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei City, Taiwan., Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Toufen, Taiwan., Clausen TD; Department of Gynecology and Obstetrics, Nordsjaellands Hospital, Hillerød, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Damm P; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.; Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., de Mello VD; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada., Dwivedi OP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Erdos MR; Center for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Fernandes Silva L; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Frayling TM; University of Exeter Medical School University of Exeter, Exeter, UK., Gieger C; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism Cedars-Sinai Medical Center, Los Angeles, CA, USA., Guo X; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Gustafsson S; Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden., Hakaste L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Hammar U; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden., Hatem G; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden., Herrmann S; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; Department of Internal Medicine III, Prevention and Care of Diabetes, Medical Faculty Carl Gustav Carus, Dresden, Germany., Højlund K; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., Horn K; Medical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, Medical Faculty, Leipzig, Germany., Hsueh WA; Internal Medicine, Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan., Hwu CM; Department of Medicine Section of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei City, Taiwan., Jonsson A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Kleber ME; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lauzon M; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Lee IT; Department of Internal Medicine Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung City, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung City, Taiwan., Lindgren CM; Big Data Institute Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.; Broad Institute, Cambridge, MA, USA., Lindström J; Finnish Institute for Health and Welfare, Helsinki, Finland., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Luan J; MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Aly DM; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden., Mathiesen E; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.; Department of Endocrinology Rigshospitalet, Copenhagen, Denmark., Moissl AP; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Institute of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany.; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena, Jena, Germany., Morris AP; Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Narisu N; Center for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Perakakis N; Department of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Peters A; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Prasad RB; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden., Rodionov RN; Department of Internal Medicine III, University Center for Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.; College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia., Roll K; Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rundsten CF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sarnowski C; Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, Houston, TX, USA., Savonen K; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Scholz M; Medical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, Medical Faculty, Leipzig, Germany., Sharma S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Food Chemistry and Molecular and Sensory Science, Technical University of Munich, Freising-Weihenstephan, München, Germany., Stinson SE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Suleman S; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tan J; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Taylor KD; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Vistisen D; Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Witte DR; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Public Health, Aarhus University, Aarhus, Denmark., Walther R; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; Department of Internal Medicine III, Pathobiochemistry, Medical Faculty Carl Gustav Carus, Dresden, Germany., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Xiang AH; Research and Evaluation, Division of Biostatistics, Kaiser Permanente Southern California, Pasadena, CA, USA., Zethelius B; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Ahlqvist E; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Chen YI; Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Collins FS; Center for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Fall T; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden., Florez JC; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, The Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Fritsche A; Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany., Grallert H; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Groop L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Lund, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Lind L; Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden., Loeffler M; Medical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, Medical Faculty, Leipzig, Germany., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany., Meigs JB; Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Clinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Lund, Sweden.; Department of Medicine Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Raffel LJ; Department of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, CA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Schwarz PEH; Helmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Department of Internal Medicine III, Prevention and Care of Diabetes, Medical Faculty Carl Gustav Carus, Dresden, Germany., Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Sundström J; Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Tuomi T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Tuomilehto J; Department of Public Health, University of Helsinki, Helsinki, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wagner R; Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Walker M; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wareham NJ; MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. karen_mohlke@med.unc.edu., Wheeler E; MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. eleanor.wheeler@mrc-epid.cam.ac.uk., O'Rahilly S; Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk., Fazakerley DJ; Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK. djf72@cam.ac.uk., Langenberg C; MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. claudia.langenberg@qmul.ac.uk.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin, Berlin, Germany. claudia.langenberg@qmul.ac.uk.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK. claudia.langenberg@qmul.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2023 Jun; Vol. 55 (6), pp. 973-983. Date of Electronic Publication: 2023 Jun 08.

Impact of a Digital Lifestyle Intervention on Diabetes Self-Management: A Pilot Study.

Autor: Bretschneider MP; Department for Prevention and Care of Diabetes, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany., Klásek J; Institute of Economic Studies, Faculty of Social Sciences, Charles University in Prague, Opletalova 26, 110 00 Prague, Czech Republic., Karbanová M; Department of Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.; First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08 Prague, Czech Republic., Timpel P; Department for Prevention and Care of Diabetes, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany., Herrmann S; Department for Prevention and Care of Diabetes, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.; Paul Langerhans Institute, Faculty of Medicine, Technische Universität Dresden, Tatzberg 47, 01307 Dresden, Germany.; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

Publikováno v: Nutrients [Nutrients] 2022 Apr 26; Vol. 14 (9). Date of Electronic Publication: 2022 Apr 26.