Investigational Use of Real-World Data as a Hybrid Control in Pancreatic Ductal Adenocarcinoma from the Randomized Phase Ib/II MORPHEUS Trial.

Autor: Ko AH; University of California San Francisco, San Francisco, California, USA., Oh DY; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Lau J; Genentech, Inc., South San Francisco, California, USA., Mhatre SK; Genentech, Inc., South San Francisco, California, USA., Ci B; Genentech, Inc., South San Francisco, California, USA., Machado R; Roche Products Ltd, Welwyn Garden City, UK., Li S; Genentech, Inc., South San Francisco, California, USA., Bretscher MT; F. Hoffmann-La Roche Ltd., Basel, Switzerland., Reyes-Rivera I; F. Hoffmann-La Roche Ltd., Basel, Switzerland., Zhu J; Genentech, Inc., South San Francisco, California, USA., Zhang X; Genentech, Inc., South San Francisco, California, USA., Patel J; Genentech, Inc., South San Francisco, California, USA., Psioda MA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA., Ponz-Sarvise M; Cancer Center Clinica Universidad de Navarra and Program in Solid Tumors (CIMA), Universidad de Navarra, IDISNA, Pamplona, Spain.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Dec 20. Date of Electronic Publication: 2024 Dec 20.

A meta-analytic framework to adjust for bias in external control studies.

Autor: Incerti D; Pharmaceutical Development, Genentech, Inc, South San Francisco, California, USA., Bretscher MT; Pharmaceutical Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Lin R; Pharmaceutical Development, Genentech, Inc, South San Francisco, California, USA., Harbron C; Pharmaceutical Development, Roche Products, Welwyn Garden City, UK.

Publikováno v: Pharmaceutical statistics [Pharm Stat] 2023 Jan; Vol. 22 (1), pp. 162-180. Date of Electronic Publication: 2022 Oct 04.

Building External Control Arms From Patient-Level Electronic Health Record Data to Replicate the Randomized IMblaze370 Control Arm in Metastatic Colorectal Cancer.

Autor: Schröder C; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Lawrance M; Roche Products Ltd, Welwyn, United Kingdom., Li C; Roche Products Ltd, Welwyn, United Kingdom., Lenain C; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Mhatre SK; Genentech Inc, South San Francisco, CA., Fakih M; City of Hope Comprehensive Cancer Center, Duarte, CA., Reyes-Rivera I; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Bretscher MT; F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Publikováno v: JCO clinical cancer informatics [JCO Clin Cancer Inform] 2021 Apr; Vol. 5, pp. 450-458.

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data.

Autor: Bretscher MT; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK. mthbretscher@gmail.com., Dahal P; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Griffin J; School of Mathematical Sciences, Queen Mary University of London, London, UK., Stepniewska K; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bassat Q; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.; ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain.; Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain.; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Baudin E; Epicentre, Paris, France., D'Alessandro U; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Djimde AA; Malaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Dorsey G; Department of Medicine, University of California San Francisco, San Francisco, USA., Espié E; Epicentre, Paris, France.; Clinical and Epidemiology Department, GSK Vaccines, R&D Center, Wavre, Belgium., Fofana B; Malaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., González R; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Juma E; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Karema C; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Lasry E; Medecins Sans Frontieres-OCBA, Barcelona, Spain., Lell B; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.; Centre de Recherches Medicales de Lambarene, Lambarene, Gabon., Lima N; Department of Paediatrics, University of Calabar, Calabar, Nigeria., Menéndez C; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Mombo-Ngoma G; Centre de Recherches Medicales de Lambarene, Lambarene, Gabon.; Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Moreira C; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nikiema F; Institut de Recherche en Science de la Sante, Bobo-Dioulasso, Burkina Faso., Ouédraogo JB; Institut de Recherche en Science de la Sante, Bobo-Dioulasso, Burkina Faso., Staedke SG; Department of Clinical Research, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Tinto H; Institut de Recherche en Science de la Sante, Nanoro, Burkina Faso., Valea I; Institut de Recherche en Science de la Sante, Nanoro, Burkina Faso., Yeka A; Uganda Malaria Surveillance Project, Kampala, Uganda., Ghani AC; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK., Guerin PJ; WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Okell LC; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK. l.okell@imperial.ac.uk.

Publikováno v: BMC medicine [BMC Med] 2020 Feb 25; Vol. 18 (1), pp. 47. Date of Electronic Publication: 2020 Feb 25.

Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions.

Autor: Georgiadou A; Section of Paediatrics, Imperial College, London, UK., Lee HJ; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Walther M; Medical Research Council Unit, Fajara, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., van Beek AE; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, The Netherlands., Fitriani F; Section of Paediatrics, Imperial College, London, UK., Wouters D; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Kuijpers TW; Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, The Netherlands.; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., Nwakanma D; Medical Research Council Unit, Fajara, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., D'Alessandro U; Medical Research Council Unit, Fajara, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Riley EM; The Roslin Institute and the Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK., Otto TD; Centre of Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Ghani A; MRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK., Levin M; Section of Paediatrics, Imperial College, London, UK., Coin LJ; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Conway DJ; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, UK., Bretscher MT; MRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.; F. Hoffmann-La Roche Ltd., Basel, Switzerland., Cunnington AJ; Section of Paediatrics, Imperial College, London, UK. a.cunnington@imperial.ac.uk.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Sep; Vol. 4 (9), pp. 1592-1602. Date of Electronic Publication: 2019 Jun 17.