Non-ablative doses of focal ionizing radiation alters function of central neural circuits

Autor: Hamed Zaer, Wei Fan, Dariusz Orlowski, Andreas N. Glud, Morten B. Jensen, Esben S. Worm, Slávka Lukacova, Trine W. Mikkelsen, Lise M. Fitting, Liisa M. Jacobsen, Thomas Portmann, Jui-Yi Hsieh, Christopher Noel, Georg Weidlich, Woody Chung, Patrick Riley, Cesare Jenkins, John R. Adler, Jr., M. Bret Schneider, Jens Christian H. Sørensen, Albrecht Stroh

Publikováno v: Brain Stimulation, Vol 15, Iss 3, Pp 586-597 (2022)

Background: Modulation of pathological neural circuit activity in the brain with a minimum of complications is an area of intense interest. Objective: The goal of the study was to alter neurons' physiological states without apparent damage of cellula

Externí odkaz: https://doaj.org/article/76bdd7eb2a3b47baa683b49d316a35df

A Perspective of International Collaboration Through Web-Based Telecommunication–Inspired by COVID-19 Crisis

Autor: Hamed Zaer, Wei Fan, Dariusz Orlowski, Andreas N. Glud, Anne S. M. Andersen, M. Bret Schneider, John R. Adler, Albrecht Stroh, Jens C. H. Sørensen

Publikováno v: Frontiers in Human Neuroscience, Vol 14 (2020)

The tsunami effect of the COVID-19 pandemic is affecting many aspects of scientific activities. Multidisciplinary experimental studies with international collaborators are hindered by the closing of the national borders, logistic issues due to lockdo

Externí odkaz: https://doaj.org/article/a24ca457cda141b1a3c4aee93ebdf343

Effects of Focal Radiation on [18F]-Fluoro-D-Glucose Positron Emission Tomography in the Brains of Miniature Pigs: Preliminary Findings on Local Metabolism

Autor: John R. Adler, Chien‐Chu Liu, Yi-Chieh Chen, Chun-I Yeh, Ngot Swan Chong, Hung‐Yi Chen, Ruoh-Fang Yen, Chau-Hwa Chi, Mohan Bodduluri, Yu-Ten Ju, Wu Liang-Hsiang, Mei-Fang Cheng, Michael Bret Schneider, Furen Xiao, Pin-Huan Yu, Yilin Chen

Publikováno v: Neuromodulation: Technology at the Neural Interface. 24:863-869

OBJECTIVES It would be a medically important advance if durable and focal neuromodulation of the brain could be delivered noninvasively and without ablation. This ongoing study seeks to elucidate the effects of precisely delivered ionizing radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faa66ff4d75d46e0b36cd463ea86ec1f
https://doi.org/10.1111/ner.13147

Self-Shielding for the ZAP-X®: Revised Characterization and Evaluation

Autor: Zander Oostman, M. Bret Schneider, Vilim Simcic, Georg A. Weidlich, John R. Adler

Publikováno v: Cureus

The ZAP-X® is a newly designed, self-contained, and first-of-its-kind self-shielded therapeutic radiation therapy device dedicated to brain and head and neck stereotactic radiosurgery (SRS). By using an S-band linear accelerator (linac) and employin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b80a3b17687a7a9d05dbb41ea69b6
https://doi.org/10.7759/cureus.13660

Radionecrosis and cellular changes in small volume stereotactic brain radiosurgery in a porcine model

Autor: John R. Adler, Hamed Zaer, Morten Bjørn Jensen, Lone Hoffmann, Slavka Lukacova, J.C Sørensen, Morten Høyer, Rune Hansen, Andreas Nørgaard Glud, Esben S. Worm, K. Hansen, Bret Schneider, Dariusz Orlowski

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Zaer, H, GLUD, AN, Schneider, B M, Lukacova, S, Vang Hansen, K, Adler, J R, Høyer, M, Jensen, M B, Hansen, R, Hoffmann, L, Worm, E S, Sørensen, J C H & Orlowski, D 2020, ' Radionecrosis and cellular changes in small volume stereotactic brain radiosurgery in a porcine model ', Scientific Reports, vol. 10, no. 1, 16223 . https://doi.org/10.1038/s41598-020-72876-w

Stereotactic radiosurgery (SRS) has proven an effective tool for the treatment of brain tumors, arteriovenous malformation, and functional conditions. However, radiation-induced therapeutic effect in viable cells in functional SRS is also suggested.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdca97e8c0c4aca696af178eb1568ee
https://pubmed.ncbi.nlm.nih.gov/33004849