Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Bret D Freudenthal"'
Autor:
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang, Patricia L Opresko, Bret D Freudenthal
Publikováno v:
eLife, Vol 9 (2020)
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for
Externí odkaz:
https://doaj.org/article/4e22fc7309344751ac64f8a5732134ad
Autor:
Brittani L. Schnable, Matthew A. Schaich, Vera Roginskaya, Liam P. Leary, Tyler M. Weaver, Bret D. Freudenthal, Alexander C. Drohat, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Base excision repair is the main pathway involved in active DNA demethylation. 5-formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an
Externí odkaz:
https://doaj.org/article/c5ab3255991842278bb091539a39a8ac
Autor:
Jie Liu, Christopher Ede, William D Wright, Steven K Gore, Shirin S Jenkins, Bret D Freudenthal, M Todd Washington, Xavier Veaute, Wolf-Dietrich Heyer
Publikováno v:
eLife, Vol 6 (2017)
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Gene
Externí odkaz:
https://doaj.org/article/05da620cad144c98b326782beef630fe
Autor:
Natasha Ramakrishnan, Tyler M. Weaver, Lindsey N. Aubuchon, Ayda Woldegerima, Taylor Just, Kevin Song, Alessandro Vindigni, Bret D. Freudenthal, Priyanka Verma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Clinical success with poly (ADP-ribose) polymerase inhibitors (PARPi) is impeded by inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 (ALC1), a chromatin-remodeling enzyme, can overcome these limitat
Externí odkaz:
https://doaj.org/article/18317155c20b482db680ad7c6ece9676
Autor:
Tyler M. Weaver, Nicole M. Hoitsma, Jonah J. Spencer, Lokesh Gakhar, Nicholas J. Schnicker, Bret D. Freudenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
AP endonuclease 1 (APE1) processes genomic AP sites during base excision repair. Here, the authors determine the structural mechanism used by APE1 to process nucleosomal AP sites, providing new insight into DNA repair in chromatin.
Externí odkaz:
https://doaj.org/article/03554504093a407299ffc39f4e3f6c96
Autor:
Tyler M. Weaver, Timothy H. Click, Thu H. Khoang, M. Todd Washington, Pratul K. Agarwal, Bret D. Freudenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Rev1 is a specialized translesion synthesis DNA polymerase involved in the bypass DNA damage during DNA replication. Here, the authors determine the structural basis for preferential incorporation of dCTP by Rev1 during bypass of DNA damage.
Externí odkaz:
https://doaj.org/article/910c77d8426543aaaf98c3556e2e1127
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, in
Externí odkaz:
https://doaj.org/article/3f8e058c49e347208faec432f78c2113
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3293-3302 (2021)
Ribonucleotides (rNTPs) are predicted to be incorporated into the genome at a rate of up to 3 million times per cell division, making rNTPs the most common non-standard nucleotide in the human genome. Typically, misinserted ribonucleotides are repair
Externí odkaz:
https://doaj.org/article/1cb17b3695494a05a1c0d6398ac3bf99
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.
Externí odkaz:
https://doaj.org/article/22fa7349443040f6a588333c1ddf1b4e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.
Externí odkaz:
https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381