Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Autor: Xiaolin Li, Martin Traebert, David McKenney, Dirksen E. Bussiere, Sylvia Ma, Katherine V. Thompson, Nirav Shah, Douglas C. Bauer, Wosenu Mergo, Duncan Armstrong, Richard Zang, Bhavin Kantariya, Jennifer A. Leeds, Bo Zhou, Ashish Patel, John Fuller, Tushar Patel, Alice Rico, William S. Sawyer, Colin Osborne, Heinz E. Moser, Mangesh Fulsunder, Yongjin Xu, Bret Benton, Swapnil Malekar, Shravanthi Madhavan, Jason Vo, Cheng Hu, Daniel Mutnick, Krunal Prajapati, Michael Wang, Katherine R Prosen, Louis E. Metzger, Carl J. Balibar, Darshit Patel, Jogitha Selvarajah, Sarah Williams, Shailesh Satasia, Peichao Lu, Bhavesh Dhumale, Kartik Shanghavi, Alexey Rivkin, Javier de Vicente, Wei Shu, Jonas Noeske, Anand Vala, Mark R. Sanderson, Cornelia Bellamacina, L. Mark Fisher, Lakhan Vala, Qin Yue, Charles R. Dean, Gianfranco De Pascale, Dennis A. Veselkov, Marcella Widya, Folkert Reck, Lauren M. Holder, Guillaume Lapointe, Colin K. Skepper, Daryl L. Richie, Anatoli Lvov

Publikováno v: Skepper, C K, Armstrong, D, Balibar, C J, Bauer, D, Bellamacina, C, Benton, B M, Bussiere, D, De Pascale, G, De Vicente, J, Dean, C R, Dhumale, B, Fisher, L M, Fuller, J, Fulsunder, M, Holder, L M, Hu, C, Kantariya, B, Lapointe, G, Leeds, J A, Li, X, Lu, P, Lvov, A, Ma, S, Madhavan, S, Malekar, S, Mckenney, D, Mergo, W, Metzger, L, Moser, H E, Mutnick, D, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Rico, A, Sanderson, M R, Satasia, S, Sawyer, W S, Selvarajah, J, Shah, N, Shanghavi, K, Shu, W, Thompson, K V, Veselkov, D A, Williams, S L, Xu, Y, Yue, Q, Zang, R, Zho, B & Rivkin, A 2020, ' Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria ', Journal of Medicinal Chemistry, vol. 63, no. 14, pp. 7773-7816 . https://doi.org/10.1021/acs.jmedchem.0c00347

Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, drive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99afdf67109b37c858dc407505690414
https://kclpure.kcl.ac.uk/ws/files/133475695/Topoisomerase_Inhibitors_Addressing_Fluoroquinolone_SKEPPER_Acc16Jun2020E_ub7Jul2020_GREEN_AAM.pdf

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Autor: Anke Blechschmidt, Brent A. Appleton, M. Geng, Jun-Rong Wei, J. de Vicente, Colin K. Skepper, Mika Lindvall, Bret Benton, Lili Xie, Brian Y. Feng, Carl J. Balibar, Qiong Zhang, Lisha Wang, Mulugeta Mamo, Valery Polyakov, Andreas Weiss, J.E. Drumm, Cindy Li, Wosenu Mergo, T.M. Smith, Kenneth T. Takeoka, Wenjian Xu, Kyoko Uehara, Yipin Lu, Robert J. Moreau, Andreas Lingel

Publikováno v: Journal of Medicinal Chemistry. 61:3309-3324

The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system. Part of our broad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19fc0e6d6b82788ced5f8da789dfb0d
https://doi.org/10.1021/acs.jmedchem.7b01691

Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics

Autor: Cindy Li, Mei Geng, Xiaoyu Shen, Joseph Drumm, Robert J. Moreau, Jun-Rong Wei, Colin K. Skepper, Bret Benton, Brian Y. Feng, Micah Steffek, Kenneth T. Takeoka, Lisha Wang, Christopher M. Rath, Wenjian Xu, Qiong Zhang, Javier de Vicente

Publikováno v: ACS infectious diseases. 4(3)

Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the requirement to simultaneously optimize molecules for target affinity and cellular potency, which can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac29e3534573882ee57273b4c32f07a9
https://pubmed.ncbi.nlm.nih.gov/29243909

Cloning and Functional Characterization of an NAD + -Dependent DNA Ligase from Staphylococcus aureus

Autor: Dongxu Sun, Patrick K. Martin, Melissa Cronan, Bret Benton, Matt Griffor, Ajith V. Kamath, Thomas D. Gootz, Donald P. Biek, Mahmoud N. Mansour, Laura McDowell, John P. Mueller, Richard P. Zaniewski, Dennis E. Danley, Molly B. Schmid, Frank S. Kaczmarek

Publikováno v: Journal of Bacteriology. 183:3016-3024

A Staphylococcus aureus mutant conditionally defective in DNA ligase was identified by isolation of complementing plasmid clones that encode the S. aureus lig A gene. Orthologues of the putative S. aureus NAD + -dependent DNA ligase could be identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bc90111aa0159c0182f1967b57c0be
https://doi.org/10.1128/jb.183.10.3016-3024.2001