Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

Autor: Bulstrode, H, Johnstone, E, Marques-Torrejon, MA, Ferguson, KM, Bressan, RB, Blin, C, Grant, V, Gogolok, S, Gangoso, E, Gagrica, S, Ender, C, Fotaki, V, Sproul, D, Bertone, P, Pollard, SM

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::51ae5f5353f658f3b39ac2580ed3b997
https://www.repository.cam.ac.uk/handle/1810/269560

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

Autor: Bulstrode, H, Johnstone, E, Marques-Torrejon, MA, Ferguson, KM, Bressan, RB, Blin, C, Grant, V, Gogolok, S, Gangoso, E, Gagrica, S, Ender, C, Fotaki, V, Sproul, D, Bertone, P, Pollard, SM

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89edb1425afdfa4966b500ad196b1eef

JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis.

Autor: Maciag G; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Hansen SL; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Krizic K; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Kellermann L; Department of Gastroenterology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark., Inventor Zøylner MJ; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Ulyanchenko S; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Maimets M; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Baattrup AM; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Riis LB; Department of Pathology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark., Khodosevich K; Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen N, Denmark., Sato T; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan., Bressan RB; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: raul.bressan@sund.ku.dk., Nielsen OH; Department of Gastroenterology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark. Electronic address: ohn@dadlnet.dk., Jensen KB; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kim.jensen@sund.ku.dk.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Aug 13; Vol. 19 (8), pp. 1172-1188. Date of Electronic Publication: 2024 Jul 18.

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation.

Autor: Pikkupeura LM; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen N DK-2200, Denmark., Bressan RB; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Guiu J; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, 3a planta, Av. Granvia de l'Hospitalet 199, Hospitalet de Llobregat 08908, Spain., Chen Y; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen N DK-2200, Denmark., Maimets M; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Mayer D; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Schweiger PJ; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Hansen SL; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Maciag GJ; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Larsen HL; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Lõhmussaar K; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Pedersen MT; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark., Teves JMY; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark., Bornholdt J; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen N DK-2200, Denmark., Benes V; GeneCore, EMBL, Heidelberg, Germany., Sandelin A; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen N DK-2200, Denmark., Jensen KB; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark.

Publikováno v: Science advances [Sci Adv] 2023 Jul 14; Vol. 9 (28), pp. eadf9460. Date of Electronic Publication: 2023 Jul 12.

Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO-2022).

Autor: Pepe RB; Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil., Lottenberg AM; Laboratório de Lipides (LIM10), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil. ana.lottenberg@hc.fm.usp.br.; Nutrition Department of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), Rua Mato Grosso 306 - cj 1711, Sao Paulo, SP, 01239-040, Brazil. ana.lottenberg@hc.fm.usp.br., Fujiwara CTH; Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil., Beyruti M; Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), São Paulo, SP, Brazil., Cintra DE; Centro de Estudos em Lipídios e Nutrigenômica - CELN - University of Campinas, Campinas, SP, Brazil., Machado RM; Liga Acadêmica de Controle de Diabetes do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Rodrigues A; Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), São Paulo, SP, Brazil., Jensen NSO; Liga Acadêmica de Controle de Diabetes do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Caldas APS; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Fernandes AE; Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil., Rossoni C; Instituto de Saúde Ambiental, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Mattos F; Programa de Obesidade e Cirurgia Bariátrica do Hospital Universitário Clementino Fraga Filho da UFRJ, Rio de Janeiro, RJ, Brazil., Motarelli JHF; Núcleo de Estudos e Extensão em Comportamento Alimentar e Obesidade (NEPOCA) da Universidade de São Paulo - FMRP/USP, Ribeirão Preto, Brazil., Bressan J; Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Saldanha J; Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil., Beda LMM; Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), São Paulo, SP, Brazil., Lavrador MSF; Liga Acadêmica de Controle de Diabetes do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil., Del Bosco M; Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), São Paulo, SP, Brazil., Cruz P; Grupo de Obesidade e Sindrome Metabolica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil., Correia PE; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Maximino P; Instituto PENSI - Fundação José Luiz Egydio Setúbal, Instituto Pensi, Fundação José Luiz Egydio Setúbal, Hospital Infantil Sabará, São Paulo, SP, Brazil., Pereira S; Núcleo de Saúde Alimentar da Sociedade Brasileira de Cirurgia Bariátrica e Metabólica, São Paulo, Brazil., Faria SL; Gastrocirurgia de Brasilia/University of Brasilia, Brasilia, DF, Brazil., Piovacari SMF; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Publikováno v: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2023 Jun 09; Vol. 15 (1), pp. 124. Date of Electronic Publication: 2023 Jun 09.