Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Brenton R, Graveley"'
Autor:
Eric L. Van Nostrand, Gabriel A. Pratt, Brian A. Yee, Emily C. Wheeler, Steven M. Blue, Jasmine Mueller, Samuel S. Park, Keri E. Garcia, Chelsea Gelboin-Burkhart, Thai B. Nguyen, Ines Rabano, Rebecca Stanton, Balaji Sundararaman, Ruth Wang, Xiang-Dong Fu, Brenton R. Graveley, Gene W. Yeo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable mapping RBP targets transcriptome-wide, b
Externí odkaz:
https://doaj.org/article/7bd753fbac7546c7ad4fb5a7375a17e9
Autor:
Ei-Wen Yang, Jae Hoon Bahn, Esther Yun-Hua Hsiao, Boon Xin Tan, Yiwei Sun, Ting Fu, Bo Zhou, Eric L. Van Nostrand, Gabriel A. Pratt, Peter Freese, Xintao Wei, Giovanni Quinones-Valdez, Alexander E. Urban, Brenton R. Graveley, Christopher B. Burge, Gene W. Yeo, Xinshu Xiao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.
Externí odkaz:
https://doaj.org/article/40fe4f1d191643449b3e71a16d4eeda4
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Understanding the functional impact of genomic variants is a major goal of modern genetics and personalized medicine. Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult
Externí odkaz:
https://doaj.org/article/d1954531613248d480f124919a3bcd46
Autor:
Louis Philip Benoit Bouvrette, Xiaofeng Wang, Jonathan Boulais, Jian Kong, Easin Uddin Syed, Steven M Blue, Lijun Zhan, Sara Olson, Rebecca Stanton, Xintao Wei, Brian Yee, Eric L Van Nostrand, Xiang-Dong Fu, Christopher B Burge, Brenton R Graveley, Gene W Yeo, Eric Lécuyer
Publikováno v:
Nucleic Acids Research. 51:D1549-D1557
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf7375a22adfc0e9b4ac3160c9a9f6b
https://doi.org/10.1093/nar/gkac971
https://doi.org/10.1093/nar/gkac971
Autor:
Sandra C. Garrett, Cecile Philippe, Jenny G. Kim, Yunzhou Wei, Katie A. Johnson, Sara Olson, Brenton R. Graveley, Michael P. Terns
Publikováno v:
Journal of Bacteriology.
Streptococcus thermophilus is an important organism for production of cultured dairy foods, but it is susceptible to lytic phages which can lead to failed products. Consequently, mechanisms for phage resistance are an active area of research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58661fc6dcc9e5c6609a0f0c33e5c2c2
https://doi.org/10.1128/jb.00482-22
https://doi.org/10.1128/jb.00482-22
Autor:
Walter T. Woodside, Nikita Vantsev, Ryan J. Catchpole, Sandra C. Garrett, Sara Olson, Brenton R. Graveley, Michael P. Terns
Publikováno v:
RNA. 28:1074-1088
CRISPR-Cas systems are functionally diverse prokaryotic antiviral defense systems, which encompass six distinct types (I–VI) that each encode different effector Cas nucleases with distinct nucleic acid cleavage specificities. By harnessing the uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fb6bf2d79cbfbd2f93a5030c85683e
https://doi.org/10.1261/rna.079206.122
https://doi.org/10.1261/rna.079206.122
Autor:
Jakub O. Westholm, Pedro Miura, Sara Olson, Sol Shenker, Brian Joseph, Piero Sanfilippo, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1966-1980 (2014)
Summary: Circularization was recently recognized to broadly expand transcriptome complexity. Here, we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues
Externí odkaz:
https://doaj.org/article/fe79549a28ff41f09b8c144dc74c610f
Autor:
Elizabeth A. Watts, Sandra C. Garrett, Ryan J. Catchpole, Landon M. Clark, Brenton R. Graveley, Michael P. Terns
Publikováno v:
Extremophiles
Pyrococcus furiosus is a hyperthermophilic archaeon with three effector CRISPR complexes (types I-A, I-B, and III-B) that each employ crRNAs derived from seven CRISPR arrays. Here, we investigate the CRISPR adaptation response to a newly discovered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531fc52509e65962ea26e54799580282
https://pubmed.ncbi.nlm.nih.gov/36385310
https://pubmed.ncbi.nlm.nih.gov/36385310
Publikováno v:
Nucleic acids research. 50(12)
Although reverse-transcriptase (RT) enzymes are critical reagents for research and biotechnology, their mechanical properties are not well understood. In particular, we know little about their relative speed and response to structural obstacles in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4465782ad0ed8e5f745433f66c631004
https://pubmed.ncbi.nlm.nih.gov/35713547
https://pubmed.ncbi.nlm.nih.gov/35713547
Autor:
Gabriel A. Pratt, Shashank Sathe, Neal A.L. Cody, Ruth Wang, Xiaofeng Wang, Peter Freese, Keri E. Garcia, Ashley L. Louie, Eric Lécuyer, Cassandra Bazile, Xintao Wei, Steven M. Blue, Rebecca Stanton, Myles Hochman, Daniel Dominguez, Balaji Sundararaman, Eric L. Van Nostrand, Michael O. Duff, Jia-Yu Chen, Nicole J. Lambert, Amanda Su, Julie Bergalet, Stefan Aigner, Tsultrim Palden, Ines Rabano, Xiang-Dong Fu, Hairi Li, Brenton R. Graveley, Chelsea Gelboin-Burkhart, Lijun Zhan, Bing Zhou, Gene W. Yeo, Christopher B. Burge, Thai B. Nguyen, Rui Xiao, Michael P. McGurk, Louis Philip Benoit Bouvrette, Brian A. Yee, Sara Olson
Publikováno v:
Nature, vol 583, iss 7818
Nature
Nature
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cdaacf41c6d6a57cdabc5d98c5fbe7
https://doi.org/10.1038/s41586-020-2077-3
https://doi.org/10.1038/s41586-020-2077-3