Výsledky vyhledávání - "Brenton D. Hoffman"

Akademický článek

Detection of fluorescent protein mechanical switching in cellulo

Autor: T. Curtis Shoyer, Kasie L. Collins, Trevor R. Ham, Aaron T. Blanchard, Juilee N. Malavade, Benjamin A. Johns, Jennifer L. West, Brenton D. Hoffman

Publikováno v: Cell Reports: Methods, Vol 4, Iss 7, Pp 100815- (2024)

Summary: The ability of cells to sense and respond to mechanical forces is critical in many physiological and pathological processes. However, determining the mechanisms by which forces affect protein function inside cells remains challenging. Motiva

Externí odkaz: https://doaj.org/article/1d829633ca9349298a176df6ee0bbc11

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Akademický článek

Molecular basis and cellular functions of vinculin-actin directional catch bonding

Autor: Venkat R. Chirasani, Mohammad Ashhar I. Khan, Juilee N. Malavade, Nikolay V. Dokholyan, Brenton D. Hoffman, Sharon L. Campbell

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract The ability of cells and tissues to respond differentially to mechanical forces applied in distinct directions is mediated by the ability of load-bearing proteins to preferentially maintain physical linkages in certain directions. However, t

Externí odkaz: https://doaj.org/article/077472f443c64a9687cc9e7896f64cc6

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Akademický článek

A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading

Autor: Benjamin D. Andress, Rebecca M. Irwin, Ishaan Puranam, Brenton D. Hoffman, Amy L. McNulty

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Meniscus injuries are highly prevalent, and both meniscus injury and subsequent surgery are linked to the development of post-traumatic osteoarthritis (PTOA). Although the pathogenesis of PTOA remains poorly understood, the inflammatory cytokine IL-1

Externí odkaz: https://doaj.org/article/8d713eafaf95476babd6f3e2f7a8e9c2

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Analysis of intracellular transport dynamics using quantitative phase imaging and FRET-based calcium sensors

Autor: Robert E Highland, Albert Rancu, Hillel Price, Steven M Parker, Meghan Reynolds, Brenton D. Hoffman, Adam Wax

Understanding cellular responses to mechanical environmental stimuli is an essential goal of cellular mechanotransduction studies and remains a target for microscopy technique development. While fluorescence microscopy has been advanced for this purp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df49c20375eda719388444c430608f3e
https://doi.org/10.1101/2023.05.05.539565

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Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch

Autor: T. Curtis Shoyer, Evan M. Gates, Jolene I. Cabe, Daniel E. Conway, Brenton D. Hoffman

Publikováno v: bioRxiv

Collective cell migration (CCM) plays important roles in development, physiological, and pathological processes. A key feature of CCM is the dynamic mechanical coupling between cells, which enables both long-range coordination and local rearrangement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc475ff8f8b53da2ace694f1b7e1a1c0
https://doi.org/10.1101/2023.01.13.523997

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Akademický článek

Tunable molecular tension sensors reveal extension-based control of vinculin loading

Autor: Andrew S LaCroix, Andrew D Lynch, Matthew E Berginski, Brenton D Hoffman

Publikováno v: eLife, Vol 7 (2018)

Molecular tension sensors have contributed to a growing understanding of mechanobiology. However, the limited dynamic range and inability to specify the mechanical sensitivity of these sensors has hindered their widespread use in diverse contexts. He

Externí odkaz: https://doaj.org/article/3541f9f7d2b149f7869c5d73af2cd0f4

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