Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Brent W. Segelke"'
Autor:
Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/283b60b31d194f008d9dc05246724a1b
Autor:
Fangqiang Zhu, Feliza A. Bourguet, William F. D. Bennett, Edmond Y. Lau, Kathryn T. Arrildt, Brent W. Segelke, Adam T. Zemla, Thomas A. Desautels, Daniel M. Faissol
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Alchemical free energy perturbation (FEP) is a rigorous and powerful technique to calculate the free energy difference between distinct chemical systems. Here we report our implementation of automated large-scale FEP calculations, using the
Externí odkaz:
https://doaj.org/article/3e982ed42e934f87b6cebdbe7454397c
Autor:
Patrik D’haeseleer, Nicole M. Collette, Victoria Lao, Brent W. Segelke, Steven S. Branda, Magdalena Franco
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Peptide-based subunit vaccines are coming to the forefront of current vaccine approaches, with safety and cost-effective production among their top advantages. Peptide vaccine formulations consist of multiple synthetic linear epitopes that together t
Externí odkaz:
https://doaj.org/article/93fa529cfacd424a89fd3f9ff2ffc386
Autor:
Magdalena Franco, Patrik M. D'haeseleer, Steven S. Branda, Megan J. Liou, Yasmeen Haider, Brent W. Segelke, Sahar H. El-Etr
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively, and are often fatal to humans and animals. Owing to the high fatality rate, potential for spread by aerosolization, and the lack of efficaciou
Externí odkaz:
https://doaj.org/article/afc40db9ae9f4e47985a500a2126d331
Autor:
Paul D. Hoeprich, Graham Bench, Brett A. Chromy, Matthew A. Coleman, William Henry Benner, Jenny A. Cappuccio, Edward A. Kuhn, Michele H. Corzett, Nicholas Fischer, Craig D. Blanchette, Brent W. Segelke, Todd A. Sulchek
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 7, Pp 2958-2971 (2009)
Heterogeneity is a fact that plagues the characterization and application of many self-assembled biological constructs. The importance of obtaining particle homogeneity in biological assemblies is a critical goal, as bulk analysis tools often require
Externí odkaz:
https://doaj.org/article/0ee3f4f80c254dcca3b7b483a617bc39
Autor:
Craig D. Blanchette, Richard Law, W. Henry Benner, Joseph B. Pesavento, Jenny A. Cappuccio, Vicki Walsworth, Edward A. Kuhn, Michele Corzett, Brett A. Chromy, Brent W. Segelke, Matthew A. Coleman, Graham Bench, Paul D. Hoeprich, Todd A. Sulchek
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 7, Pp 1420-1430 (2008)
Self-assembly of purified apolipoproteins and phospholipids results in the formation of nanometer-sized lipoprotein complexes, referred to as nanolipoprotein particles (NLPs). These bilayer constructs are fully soluble in aqueous environments and hol
Externí odkaz:
https://doaj.org/article/c73175892234465182736f2559d216dd
Autor:
Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Bernadeta Dadonaite, Brenden K. Petersen, Taylor B. Engdahl, Elaine Chen, Laura S. Handal, Lynn Hall, John W. Goforth, Denis Vashchenko, Sam Nguyen, Dina R. Weilhammer, Jacky Kai-Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, Tracy Weisenberger, Tek-Hyung Lee, Bradley Whitener, James B. Case, Alexander Ladd, Mary S. Silva, Rebecca M. Haluska, Emilia A. Grzesiak, Christopher G. Earnhart, Svetlana Hopkins, Thomas W. Bates, Larissa B. Thackray, Brent W. Segelke, Antonietta Maria Lillo, Shivshankar Sundaram, Jesse Bloom, Michael S. Diamond, James E. Crowe, Robert H. Carnahan, Daniel M. Faissol
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1–3, but also revealed how quickly viral escape can curtail effective options4, 5. With the emergence of the SARS-CoV-2 Omicron variant in
Autor:
Xiyu Yi, Haichao Miao, Jacky Kai-yin Lo, Maher M. Elsheikh, Tek-Hyung Lee, Chenfanfu Jiang, Yuliang Zhang, Brent W. Segelke, K. Wesley Overton, Peer-Timo Bremer, Ted A. Laurence
Publikováno v:
Biomed Opt Express
Legionella is a genus of ubiquitous environmental pathogens found in freshwater systems, moist soil, and composted materials. More than four decades of Legionella research has provided important insights into Legionella pathogenesis. Although standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5ce98596bfbcdbffaaf540ae80559d
https://europepmc.org/articles/PMC9408256/
https://europepmc.org/articles/PMC9408256/
Autor:
Xiyu Yi, Haichao Miao, Jacky Kai-Yin Lo, Maher M. Elsheikh, Tek Hyung Lee, Chenfanfu Jiang, Yuliang Zhang, Brent W. Segelke, K. Wesley Overton, Peer-Timo Bremer, Ted A. Laurence
Legionella is a genus of ubiquitous environmental pathogens found in freshwater systems, moist soil, and composted materials. More than four decades of Legionella research has provided important insights into Legionella pathogenesis [1]. Although sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45632535a3f4cf2c02ba531a6dd61049
https://doi.org/10.1101/2022.03.20.485032
https://doi.org/10.1101/2022.03.20.485032
Autor:
Adam Zemla, Thomas Desautels, Edmond Y. Lau, Fangqiang Zhu, Kathryn T. Arrildt, Brent W. Segelke, Shankar Sundaram, Daniel Faissol
SummaryRapid assessment of whether a pandemic pathogen may have increased transmissibility or be capable of evading existing vaccines and therapeutics is critical to mounting an effective public health response. Over the period of seven days, we util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b36f22cf7ebc15cbd954ab2360e111
https://doi.org/10.1101/2021.12.16.472843
https://doi.org/10.1101/2021.12.16.472843